DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and ddx18

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001003411.1	Gene:	ddx18 / 321127	ZFINID:	ZDB-GENE-030131-9685	Length:	653	Species:	Danio rerio

Alignment Length:	735	Identity:	213/735 - (28%)
Similarity:	352/735 - (47%)	Gaps:	167/735 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 KLSEEQITRALKSNKKPKNPNQLPTPGDLFRAQLEEERRQKRRE-----EGGGDQEASADEEDAK 217
            |:..::|.:..:.||:.|          |.::|.|||..::.::     |...|...:..||..:
Zfish     7 KILRKKIQKISEKNKQRK----------LLQSQKEEENSEEVKDVLDESEVASDSAPNVIEEQQQ 61

  Fly   218 NNSGGGSPRVKPSSAVKESKKSSDIEDSGESGEESATSDEEPDESSAQ-SPGQEKEPK----QTA 277
            :.|...:   :.|...|:.||...::.:|||...|....::....:.| |.|:|::.:    :|.
Zfish    62 SVSDEVN---ETSQKPKKKKKKRKLDATGESTTSSVKKAKKQSVDTTQASAGEEEQQEEGNLETV 123

  Fly   278 KKPP--------KAEETSSTN--RFRTKKIGLFDQSDVEALKQ-LGQRAVKPVKETIFTGSKIST 331
            |.|.        .|||.|..:  :..:...|.|:.....:|.: :.:..:|.|||
Zfish   124 KCPENGNNEKEGSAEEDSDEDGPQLPSGLTGAFEDRSFASLSEVVSENTLKGVKE---------- 178

  Fly   332 LGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVELLQKQQPR 396
                          :....:|.:|.|||..:|:|:|||..::||||||||:.:|.:||:.|.  :
Zfish   179 --------------MGFDTMTEIQHKTIRPLLEGRDVLAAAKTGSGKTLAFLIPSIELIYKL--K 227

  Fly   397 IQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGSLLGGESRKSEKARLRKGINILIGTP 461
            ...::|...:|:.|||||.||||.::::|:..:.... |.::||.:|.:|..:|..|:|||:.||
Zfish   228 FMPRNGTGVIVLSPTRELAMQTYGVLKELMTHHVHTY-GLIMGGSNRSAEAQKLANGVNILVATP 291

  Fly   462 GRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRAECEDKELPQLQRMLL 526
            |||:|||.:|..|....||.||:|||||:||:|:|.::||:::.:.|:|           |.||.
Zfish   292 GRLLDHLQNTPGFMFKNLQCLIIDEADRILEVGFEEELKQIIKLLPKKR-----------QSMLF 345

  Fly   527 SATLTSQVQQLAGLTL-KNPLYI---DNSDEAASAALKSKDGYQKETIEALLEVDDGLGEYQEDV 587
            |||.|.:|:.||.::| |.|||:   ||.|.|              |:
Zfish   346 SATQTRKVEDLARISLKKEPLYVGVDDNKDTA--------------TV----------------- 379

  Fly   588 TGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALT 652
                   |.|:..|||.|.:.|.:.|.:.|.|.     ::.|.:||.|:...|.||:::||..
Zfish   380 -------EGLEQGYVVCPSEKRFLLLFTFLKKN-----RKKKLMVFFSSCMSVKFHYELLNYI-- 430

  Fly   653 RRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCASCVLLATDVVGRG 717
                               |:|::      .:||...||:|...|..|.:..|.:||.|||..||
Zfish   431 -------------------DLPVM------AIHGKQKQTKRTTTFFQFCNADSGILLCTDVAARG 470

  Fly   718 IDVPDIKLVVQYTPPQTTADFVHRVGRTARA--GRKGRAVLFLTPSEAQFVRHLEKKRIRIQQGD 780
            :|:|::..:||:.||....:::||||||||.  || |.|:|.|.|.|..|:|.|::.::.:.:
Zfish   471 LDIPEVDWIVQFDPPDDPKEYIHRVGRTARGINGR-GHALLILRPEELGFLRFLKQAKVPLSE-- 532

  Fly   781 MYAYLQTLLPKDDEARTVQEAASNLQHKFQTLLEDDRELHDKSCKAFVSWMKFYSTFPKELKPIF 845
             :.:..|.:             |::|.:...|:|.:..||..:.:|:.|:::.|.:  ..||.|:
Zfish   533 -FEFSWTKI-------------SDIQSQLDKLIEKNYYLHKSAQEAYKSYVRAYDS--HSLKQIY 581

  Fly   846 NVRIAHMGHFAKSFALKEAP 865
            ||....:...|.||..|..|
Zfish   582 NVETLDLPKVAMSFGFKVPP 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	20/94 (21%)
		P-loop_NTPase	332..548	CDD:304359	85/216 (39%)
		DEXDc	348..554	CDD:214692	89/209 (43%)
		HELICc	601..757	CDD:238034	52/157 (33%)
		DUF4217	805..866	CDD:290667	18/61 (30%)
ddx18	NP_001003411.1	SrmB	160..646	CDD:223587	177/569 (31%)
		DEADc	161..368	CDD:238167	90/244 (37%)
		HELICc	382..511	CDD:238034	53/161 (33%)
		DUF4217	543..601	CDD:290667	17/59 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920