DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and DDX51

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_778236.2	Gene:	DDX51 / 317781	HGNCID:	20082	Length:	666	Species:	Homo sapiens

Alignment Length:	725	Identity:	199/725 - (27%)
Similarity:	309/725 - (42%)	Gaps:	199/725 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 LFRAQLEEERRQKRREEGGGDQEASADEEDAK------------NNSGGGSPRVKPSSAVKESKK 238
            |.|.|.....||::||.  ...||:|..|.|.            |::..|||     .|.:..::
Human    35 LERLQSRARERQQQREP--AQTEAAASTEPATRRRRRPRRRRRVNDAEPGSP-----EAPQGKRR 92

  Fly   239 SSDIEDSG-ESGEE------SATSDEEPDE----SSAQSPGQEKEPKQTAKKP--PKAEETSSTN 290
            .:|.||:| ||.||      :.:|:|.|.|    ||.::||:..........|  |..||.:.
Human    93 KADGEDAGAESNEEAPGEPSAGSSEEAPGEPSAGSSEEAPGERSTSASAEAAPDGPALEEAAG-- 155

  Fly   291 RFRTKKIGLFDQSDVEALKQLGQRAVKPVKETIFTGSKISTLGLHPHAVKN--LEDLLSIRELTS 353
               ....||       .|...|:|  |..|...|....::    .|:.|:.  .|||:.|.::..
Human   156 ---PLVPGL-------VLGGFGKR--KAPKVQPFLPRWLA----EPNCVRRNVTEDLVPIEDIPD 204

  Fly   354 -------------------VQQKTIPEVLQG--------------KDVLVRSQTGSGKTLAYALP 385
                               ||...||.:|:.              .|:.|.:.||||||||:.:|
Human   205 VHPDLQKQLRAHGISSYFPVQAAVIPALLESAACGFLVGRGGYRPSDLCVSAPTGSGKTLAFVIP 269

  Fly   386 LVE-LLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVP--GSLLGGES--RKS 445
            :|: ||.:....|:      |||::||:||..|    :.|:...||...|  .||:.|:.  .|.
Human   270 VVQALLSRVVCHIR------ALVVLPTKELAQQ----VSKVFNIYTDATPLRVSLVTGQKSLAKE 324

  Fly   446 EKARLRKG-------INILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLV 503
            :::.::|.       .:|::.||||||||:..|..|.|.:|:|||:|||||:::..::..:.::|
Human   325 QESLVQKTADGYRCLADIVVATPGRLVDHIDQTPGFSLQQLRFLIIDEADRMIDSMHQSWLPRVV 389

  Fly   504 EA-------------IDKQRAE--------CEDKELPQLQRMLLSATLTSQVQQLAGLTLKNPLY 547
            .|             :.:::|:        |  .::| ||::|.|||||...::|..|.|..|..
Human   390 AAAFQSEDPADPCALLQRRQAQAVTAASTCC--PQMP-LQKLLFSATLTQNPEKLQQLGLHQPRL 451

  Fly   548 IDNSDEAASAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLR--- 609
            .  |...|...|:..||            |...|:|        :.|..|...|  ||..|.
Human   452 F--STGLAHRGLEDTDG------------DGDSGKY--------AFPVGLTHHY--VPCSLSSKP 492

  Fly   610 LVALSSLLAKEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIP 674
            ||.|..:|  |:..|    :.:.|.::.|  |.|...|
Human   493 LVVLHLVL--EMGFS----RVLCFTNSRE--NSHRLFL--------------------------- 522

  Fly   675 LLQ---GLRFFKLHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTA 736
            |:|   |:...:........:|:.:.:.|......:|::||...|||||..::|||.|..||...
Human   523 LVQAFGGVDVAEFSSRYGPGQRRMILKQFEQGKIQLLISTDATARGIDVQGVELVVNYDAPQYLR 587

  Fly   737 DFVHRVGRTARAGRKGRA-VLFLTPSEAQFVRHL-EKKRIRIQQGDMYA-YLQTLLPKDDEARTV 798
            .:|||||||||||:.|:| .|.|...|.:|:|.| |.....:|:.::.: .||.|:|:.:||.:.
Human   588 TYVHRVGRTARAGKTGQAFTLLLKVQERRFLRMLTEAGAPELQRHELSSKLLQPLVPRYEEALSQ 652

  Fly   799 QEAASNLQHK 808
            .|.:...:.|
Human   653 LEESVKEERK 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	28/106 (26%)
		P-loop_NTPase	332..548	CDD:304359	81/283 (29%)
		DEXDc	348..554	CDD:214692	77/271 (28%)
		HELICc	601..757	CDD:238034	47/162 (29%)
		DUF4217	805..866	CDD:290667	1/4 (25%)
DDX51	NP_778236.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	9..152		35/123 (28%)
		TMEM119	<79..159	CDD:292352	24/89 (27%)
		PRK01297	109..609	CDD:234938	158/589 (27%)
		P-loop_NTPase	205..449	CDD:304359	74/256 (29%)
		Q motif	221..229		2/7 (29%)
		DEAD box	371..374		2/2 (100%)
		Helicase_C	489..600	CDD:278689	39/145 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920