DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and Ddx31

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001101294.2	Gene:	Ddx31 / 311835	RGDID:	1304895	Length:	682	Species:	Rattus norvegicus

Alignment Length:	758	Identity:	272/758 - (35%)
Similarity:	408/758 - (53%)	Gaps:	99/758 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 RAQLEEERRQKRREEGGGDQEASADEEDAKNNSGGGSPRVKPSSAVKESKKSSDIEDSGESGEES 252
            |.|.|..:|:         .:.|:|...||..:     .:...||.|.|.|.:.....|.:.:..
  Rat     2 RRQTEATKRK---------HQVSSDAPPAKRRN-----EISSLSAKKASNKETQRAFKGSAHKTF 52

  Fly   253 ATSDEEPDESSAQSPGQEKEPKQTAKKPPKAEETSSTNRFRTKKIGLFDQSDVEALKQLGQRAVK 317
                  |.:....:.|.|::.::...|      |||          ||..:  ..:.:|.:..||
  Rat    53 ------PPKKHLDTIGNERQEEKPCVK------TSS----------LFKNN--PEIPELHRTVVK 93

  Fly   318 PVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAY 382
            ..:|.:|:......|.||||.:..:..:|.:..:||||:::||.:|:|:|.||||||||||||||
  Rat    94 QAREQVFSPEAFQELDLHPHLISTINTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAY 158

  Fly   383 ALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGSLLGGESRKSEK 447
            .:|:|:.||....:|||.||..|||:||||||.:|:::.:|||:||:||||||.|:|||.|||||
  Rat   159 CIPVVQSLQALTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEK 223

  Fly   448 ARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRAE 512
            |||||||||||.||||||||:..|.:....::::|::|||||:|:||:|:||..::.|::   ||
  Rat   224 ARLRKGINILISTPGRLVDHIKSTKNIHFNRVRWLVVDEADRILDLGFEKDVTVILNAVN---AE 285

  Fly   513 CEDKELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETIEALLEVD 577
            |:.:     |.:|||||||..|.:||.::|.||:.|...|       ||.|....:.: |.:::|
  Rat   286 CQKR-----QNVLLSATLTEGVTRLADISLHNPVSISVLD-------KSWDQPNPKEV-ASIQLD 337

  Fly   578 DGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEMVNF 642
            .            .:|||:|....|:||.|||||.|::.:.|:......| |.|||.|:.|:|.|
  Rat   338 S------------FAIPESLDQYVVLVPSKLRLVCLAAFILKKCKFEKDQ-KMIVFFSSCELVEF 389

  Fly   643 HHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCASCV 707
            |:::....|.........|.....|         ..|:|.:|||:|.|.||..||..|....:.|
  Rat   390 HYNLFLHTLLCHSGTPASETLPSAS---------WPLKFLRLHGNMKQEERTSVFHEFSHSGTGV 445

  Fly   708 LLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQFVRHLEKK 772
            ||.|||..||:|:|.:..:|||:.|...|:::||:|||||.|..|.::|.|.||||::|..|...
  Rat   446 LLCTDVASRGLDLPQVTWIVQYSAPSAPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLASH 510

  Fly   773 RIRIQQGDMYAYLQTLLPKDD---------------EARTVQEAASNLQHKFQTLLEDDRELHDK 822
            :|.:.:..:...| .:|.|||               ..:.::|.|:.||..|:..:...:.:...
  Rat   511 KINVSEIKLEGIL-AVLAKDDCFKRRQRGAQRSHATGPQEIRERATVLQTVFEDYVHSSQRMVSW 574

  Fly   823 SCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPSKF---AAKHAAPKAAPPTNRL 884
            :.||..|:::.|:|:|||||.||:||..|:||.||||.|::||...   |.:.|:.|...|..:
  Rat   575 AKKALQSFIRAYATYPKELKSIFHVRSLHLGHVAKSFGLRDAPRNLGVSAVRKASFKRPDPRRK- 638

  Fly   885 TYTERDPEKIQAQ-KRAKRRFTTTVSGEVRQLQQRDVGAQKPG 926
              |:|....:.|: ..::.......:|...:.|...|...|||
  Rat   639 --TQRKHHLVPAEVLHSEHSSGLEGNGPKGRKQGLRVAPSKPG 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	14/81 (17%)
		P-loop_NTPase	332..548	CDD:304359	118/215 (55%)
		DEXDc	348..554	CDD:214692	114/205 (56%)
		HELICc	601..757	CDD:238034	59/155 (38%)
		DUF4217	805..866	CDD:290667	26/60 (43%)
Ddx31	NP_001101294.2	SrmB	101..635	CDD:223587	234/572 (41%)
		DEADc	105..317	CDD:238167	118/219 (54%)
		HELICc	347..495	CDD:238034	59/157 (38%)
		DUF4217	557..618	CDD:290667	26/60 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334950
Domainoid	1	1.000	215	1.000	Domainoid score	I2640
eggNOG	1	0.900	-	-		E2759_KOG0348
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6389
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1788
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250484at33208
OrthoFinder	1	1.000	-	-		FOG0003502
OrthoInspector	1	1.000	-	-		oto97253
orthoMCL	1	0.900	-	-		OOG6_102676
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2393
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800