DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and Ddx10

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001100290.1	Gene:	Ddx10 / 300710	RGDID:	1308990	Length:	874	Species:	Rattus norvegicus

Alignment Length:	667	Identity:	185/667 - (27%)
Similarity:	304/667 - (45%)	Gaps:	145/667 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 QEKEPKQTAKKPPKAEETSSTNRFRTKKIGLFDQSDVEALKQLGQRAVKPVKETIFTGSKISTLG 333
            |:||.::..|||....|....:|....    :::.:|..:                  ::.|...
  Rat    33 QKKERRKQLKKPEWQVEREGISRLMQN----YEKINVNEI------------------TRFSDFP 75

  Fly   334 LHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQ 398
            |....:|.|:: ...|.:|.:|::||...|||||||..::||||||||:.:|::|.|.:.|  ..
  Rat    76 LSKKTLKGLQE-AQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQ--WT 137

  Fly   399 RKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGSLLGGESRKSEKARLRKGINILIGTPGR 463
            ..||:..|:|.|||||..||:|:::|:.|.:.:.. |.::||:..|.|..|: ..||||:.||||
  Rat   138 STDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSA-GLIIGGKDLKHEAERI-NNINILVCTPGR 200

  Fly   464 LVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRAECEDKELPQLQRMLLSA 528
            |:.|:..|..|..|.||.|:||||||:|::|:...:..::|.:.|:|           |.:|.||
  Rat   201 LLQHMDETICFHATNLQMLVLDEADRILDMGFADTMNAIIENLPKKR-----------QTLLFSA 254

  Fly   529 TLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSI 593
            |.|..|:.||.|:||:|.|:...::|                           :|        |.
  Rat   255 TQTKSVKDLARLSLKDPEYVWVHEKA---------------------------KY--------ST 284

  Fly   594 PENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDE 658
            |..|:.:|::.....::..|.|.|...:..     |:|||.|:.:.|.:    |.....|
  Rat   285 PATLEQNYIICELHQKISVLFSFLRSHLTK-----KSIVFFSSCKEVQY----LYRVFCR----- 335

  Fly   659 EDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGIDVPDI 723
                            |..|:....|||...|..|..|:..|....:.||.|||:..||:|.|.:
  Rat   336 ----------------LRPGISILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAV 384

  Fly   724 KLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQ-FVRHLEKKRIRIQQGDMYAYLQT 787
            ..|:|:..|:....::||.|||||....|.|:|.|.|||.| .|:.|.:|::.::
  Rat   385 NWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEEQGMVQQLLQKKVPVK---------- 439

  Fly   788 LLPKDDEARTVQEAASNLQHKFQTLLEDDRELHDKSCKAFVSWMKFYSTFPKELKPIFNVRIAHM 852
                  |.:...|...::|.:.::.|..|::|.:::.:.|||:::  |.:..:.|.:|:|....:
  Rat   440 ------EIKINPEKLIDVQKRLESFLAQDQDLKERAQRCFVSYIR--SVYLMKDKEVFDVNKLPI 496

  Fly   853 GHFAKSFAL------------KEAPSKFAAKHAAPKAAPP-TNRLTYTERD------PEKIQAQK 898
            ..:|.|..|            ::.|:|...|:...:|..| ...||..|.:      .||:....
  Rat   497 TEYALSLGLAVAPRIRFLQKMEKQPNKELGKNQVTEAIQPRAPSLTSDEVEEFRAYFSEKMSILH 561

  Fly   899 RAKRRFTTT----VSGE 911
            ::.:|...|    .|||
  Rat   562 KSGKRLEETEHSLASGE 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	6/15 (40%)
		P-loop_NTPase	332..548	CDD:304359	87/215 (40%)
		DEXDc	348..554	CDD:214692	85/205 (41%)
		HELICc	601..757	CDD:238034	42/155 (27%)
		DUF4217	805..866	CDD:290667	14/72 (19%)
Ddx10	NP_001100290.1	SrmB	69..538	CDD:223587	166/567 (29%)
		DEADc	71..275	CDD:238167	89/219 (41%)
		HELICc	288..418	CDD:238034	43/159 (27%)
		DUF4217	451..510	CDD:290667	14/60 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920