DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and C24H12.4

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_740966.1	Gene:	C24H12.4 / 173432	WormBaseID:	WBGene00016073	Length:	634	Species:	Caenorhabditis elegans

Alignment Length:	750	Identity:	176/750 - (23%)
Similarity:	291/750 - (38%)	Gaps:	203/750 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 PSSAVKESKKSSDIEDSGESGEESATSDEEPDESSAQSPGQEKEPKQ---TAKKPPKAEETSSTN 290
            |....|:.:||...            ::|||.:.. ::|.::|..|:   :.:...|.||.....
Worm     3 PDEVTKKKRKSVKF------------AEEEPPKVK-EAPKKQKAGKKIEVSVELRDKNEEKMGRK 54

  Fly   291 R-FRTKKIGLFDQSDVEALKQLGQRAVKP-VKETIF--TGSKISTLGLHPHAVKNLEDLLSIREL 351
            | .|.||      |..|..::|.:..|.| |.|..|  .....:..||....:|::.: |...:.
Worm    55 RKHRMKK------SQAEKRQKLMESLVGPQVDEMDFEPEHKTFADFGLDERILKSIGE-LGWEKA 112

  Fly   352 TSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQRKDGVLALVIVPTRELVM 416
            ..||:..|...|:.|:::.|::||||||.|:.:|||:.|..:........|..|::|.||:||:.
Worm   113 NQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAESKTNDGSVGPSAVIIAPTKELIT 177

  Fly   417 QTYELIQKLVKPYTWIVPGSLLGGESRKSEKARLRKGINILIGTPGRLVDHLLHTASFK---LTK 478
            |.|:|..||.:...::...:|. ..:.:.....|....::::.|||:    ||...|.:   .|.
Worm   178 QIYKLFVKLSQALPFLQAINLC-DINEEENSVWLEDRSHVVVTTPGK----LLRMCSLRPEYCTL 237

  Fly   479 LQFLILDEADRLLELGYERDVKQLVEAIDKQRAECEDKELPQLQRMLLSATLTSQVQQLAGLTLK 543
            :.:|::||||.||..|||.::.::           ..|..|..|.::.||||...:..|..|.:.
Worm   238 VSYLVMDEADLLLSFGYEEEMIKI-----------RSKLPPTYQCLMTSATLKDDMTTLKKLFMT 291

  Fly   544 NPLYIDNSDEAASAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKL 608
            .|:          ..:|..:|.        |...|.|.:||     :....:..:.:.:|...||
Worm   292 GPV----------ITIKLTEGD--------LPNSDQLTQYQ-----LTCGSDEERFAILVAMFKL 333

  Fly   609 RLVALSSLLAKEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDI 673
            :|:...|:|.  |:...:.:|.::.:                   ||.
Worm   334 KLIVGRSILF--VNTIDRCYKLMLIL-------------------RVF----------------- 360

  Fly   674 PLLQGLRFFKLHGSMTQTERQGVFRGFRDCASCVLLATDV------------------------- 713
                ||:...|:.:|....|..|...|.:.:..:::|:||
Worm   361 ----GLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDVSDADGSKLKEEIAGKSDEKPEKDEK 421

  Fly   714 -------------VGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQF 765
                         |.||||...:..||.:..|:||..::||||||||...||.|:.|..|||.
Worm   422 KGKKASKLDKESGVSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFNKGTALSFCIPSER-- 484

  Fly   766 VRHLE--KKRIRIQQG----DMYAY----LQTLLPKDDEART------VQEA-----------AS 803
             .|||  ::.|..|.|    ..|.:    |.|.|.:..||.:      :::|           ::
Worm   485 -AHLEQIQEEINQQMGRKVLQPYEFRIKELDTFLLRTREALSKCTKGVIKKARLKEIRQELMRSA 548

  Fly   804 NLQHKFQTLLEDDRE--LHDKSCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPS 866
            |||..|   .:::||  |....|            .|..|| |.:..||.:..:....||:
Worm   549 NLQTFF---AKNEREKLLMQTDC------------HPVMLK-INSPAIADVTSYMVPEALR---- 593

  Fly   867 KFAAKHAAPKAAPPTNRLTYTERDPEKIQAQKRAK 901
              ....:||.|......:....|...|.:.||:.|
Worm   594 --GMDFSAPGAKNRRYNMGQKHRQKLKHKFQKKGK 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	11/58 (19%)
		P-loop_NTPase	332..548	CDD:304359	62/218 (28%)
		DEXDc	348..554	CDD:214692	58/208 (28%)
		HELICc	601..757	CDD:238034	41/193 (21%)
		DUF4217	805..866	CDD:290667	15/62 (24%)
C24H12.4	NP_740966.1	SrmB	46..561	CDD:223587	147/608 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010