DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and B0511.6

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_492779.1	Gene:	B0511.6 / 172954	WormBaseID:	WBGene00015232	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	684	Identity:	191/684 - (27%)
Similarity:	314/684 - (45%)	Gaps:	171/684 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 KKSSDIEDSGESGEESATSDEEPDESSAQSPGQEKEPKQTAKKPPKAEETSST--NRFRTKKI-- 297
            :|...::|..|..:......|||.|...:...:|::..||       ||:|.|  :.|.||..
Worm    12 RKLKQMKDGHEKKKAKEVVVEEPMEEEDEEEVEEEQKHQT-------EESSETKVSEFLTKTTFA 69

  Fly   298 ---GLFDQSDVEALKQLGQRAVKPVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTI 359
               |..:.:.::|::.||           ||                        .:|.:|.|:|
Worm    70 SLEGKVNANLLKAVQGLG-----------FT------------------------TMTEIQAKSI 99

  Fly   360 PEVLQGKDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQK 424
            ..:|:|||||..::||||||||:.||.:|||.|...:.....||  :::.|||||.||||.::.:
Worm   100 DPLLEGKDVLASAKTGSGKTLAFLLPAIELLHKLNWKQHNGTGV--IIVSPTRELSMQTYGVLSE 162

  Fly   425 LVKPYTWIVPGSLLGGESRKSEKARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADR 489
            |::... :..|.::||.:|.:||.:|.||::||:.|||||:|||.:|.:|.:..::.||:|||||
Worm   163 LLEGSN-LTYGLVMGGSNRSAEKDKLAKGVSILVATPGRLLDHLQNTDNFLVRNMKCLIIDEADR 226

  Fly   490 LLELGYERDVKQLVEAIDKQRAECEDKELPQLQRMLLSATLTSQVQQLAGLTL-KNPLYIDNSDE 553
            :|::|:|.:::|::..:.|||           |.||.|||.:.:|.:|..|.| .||:.:...::
Worm   227 ILDIGFEIEMQQVLRHLPKQR-----------QSMLFSATHSPKVDELVKLALHSNPVRVSVHEK 280

  Fly   554 AASAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLA 618
            |..|.:                                   |.||..|:|.|...||:.|.:.|.
Worm   281 AEEATV-----------------------------------EGLQQGYIVAPSDKRLLLLFTFLK 310

  Fly   619 KEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFK 683
            |.     |..|.:||.|:...|.|||::||..                     |||.:      .
Worm   311 KN-----KTKKVMVFFSSCNSVKFHHELLNYI---------------------DIPCM------S 343

  Fly   684 LHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTAR- 747
            :||...|.:|...|..|....:.:||.|||..||:|:|.:..:|||.|.....:::||||||||
Worm   344 IHGKQKQQKRTTTFFQFCQAETGILLCTDVAARGLDIPAVDWIVQYDPTDEPREYIHRVGRTARG 408

  Fly   748 AGRKGRAVLFLTPSEAQFVRHLEKKRIRIQQGDMYAYLQTLLPKDDEARTVQEAASNLQHKFQTL 812
            ....|:|:|.|.|.|..|:|:|:..::.:                :|........:|:|.:.:.|
Worm   409 TNGSGKALLVLRPEELGFLRYLKAAKVTL----------------NEFEFSWSKVANIQSQLENL 457

  Fly   813 LEDDRELHDKSCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPSKFAAKHAAPKA 877
            :..:..|:..:.:|:..:::.|.:  ..||.||:|....:...:|||..               :
Worm   458 ISKNYYLNKSAKEAYKCYLRAYDS--HSLKDIFDVTNMDLTAVSKSFGF---------------S 505

  Fly   878 APPTNRLTYTERDPEKIQAQ------KRAKRRFT 905
            .||...|..:.:...:|:::      ::.|:.||
Worm   506 VPPFVDLPISNKPKVEIRSKLSGAGYRKKKQSFT 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	10/47 (21%)
		P-loop_NTPase	332..548	CDD:304359	83/216 (38%)
		DEXDc	348..554	CDD:214692	83/206 (40%)
		HELICc	601..757	CDD:238034	51/156 (33%)
		DUF4217	805..866	CDD:290667	13/60 (22%)
B0511.6	NP_492779.1	DEADc	68..276	CDD:238167	89/256 (35%)
		DEXDc	83..291	CDD:214692	91/291 (31%)
		Helicase_C	312..407	CDD:278689	39/126 (31%)
		DUF4217	450..508	CDD:290667	13/74 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920