DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and Ddx1

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_598801.1	Gene:	Ddx1 / 104721	MGIID:	2144727	Length:	740	Species:	Mus musculus

Alignment Length:	693	Identity:	137/693 - (19%)
Similarity:	226/693 - (32%)	Gaps:	312/693 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 STLGLHP---HAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLV---- 387
            |.:|:.|   .||:.::.||.    |.:|.::||.:|.|.|||:.::||||||.|:::|::
Mouse     5 SEMGVMPEIAQAVEEMDWLLP----TDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVY 65

  Fly   388 ELLQKQQP--------------------------------------------------------- 395
            |.|:.||.
Mouse    66 ETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRGTRGLLK 130

  Fly   396 ----------------------------------------------------------------- 395

Mouse   131 GKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCY 195

  Fly   396 ----------------------------------------------------RIQRKDGVL---- 404
                                                                :...|||.:
Mouse   196 LDIDKGHVKFSKNGKDLGLAFEIPAHIKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSK 260

  Fly   405 ----------------------------ALVIVPTRELVMQTYELIQKLVKPYTWIVPGSL---- 437
                                        ||::.|:|||..||...:::..|   :|....|
Mouse   261 APDNYIVKSQHTGNAQVSQTKFLPNAPKALIVEPSRELAEQTLNNVKQFKK---YIDNPKLRELL 322

  Fly   438 -LGGESRKSEKARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQ 501
             :||.:.:.:.:.|..|::|::|||||| |.|:.|....|::::||:|||||.||..||...:.:
Mouse   323 IIGGVAARDQLSVLDNGVDIVVGTPGRL-DDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINR 386

  Fly   502 LVEAIDKQRAECEDKELPQLQRMLLSATLTS-QVQQLAGLTLKNPLYIDNSDEAASAALKSKDGY 565
            :...|  .:..|:.|   :||.::.||||.| .|::|:...:..|.::|         ||.:|
Mouse   387 MHNQI--PQITCDGK---RLQVIVCSATLHSFDVKKLSEKIMHFPTWVD---------LKGED-- 435

  Fly   566 QKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAK------EVDA- 623
                                      |:|:.:.  :||||...:...|...|.|      :|.|
Mouse   436 --------------------------SVPDTVH--HVVVPVNPKTDKLWERLGKNHIRTDDVHAK 472

  Fly   624 --------SPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQ------EKGDSDD----- 669
                    ||:.:...:.:           :..|...|.:.:.:.:|      .|.|.|:
Mouse   473 DNTRPGANSPEMWSEAIKI-----------LKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYF 526

  Fly   670 --DGDIPLLQGLRF--FKLHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYT 730
              .|..|..:|.:|  ..|||.....||:.....|:......|:.|||..||||:..:..|:..|
Mouse   527 MQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVT 591

  Fly   731 PPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQFVRHLEKKR 773
            .|....::|||:||..||.|.|.|:..:...:.:...|:...|
Mouse   592 LPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSNR 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302
		P-loop_NTPase	332..548	CDD:304359	80/434 (18%)
		DEXDc	348..554	CDD:214692	75/421 (18%)
		HELICc	601..757	CDD:238034	48/185 (26%)
		DUF4217	805..866	CDD:290667
Ddx1	NP_598801.1	Necessary for interaction with RELA. /evidence=ECO:0000250\|UniProtKB:Q92499	1..525		104/582 (18%)
		Interaction with dsRNA. /evidence=ECO:0000269\|PubMed:21703541	1..448		90/494 (18%)
		Necessary for interaction with HNRNPK. /evidence=ECO:0000250\|UniProtKB:Q92499	1..295		33/293 (11%)
		P-loop_NTPase	4..>72	CDD:304359	26/70 (37%)
		SPRY_DDX1	93..245	CDD:293933	0/151 (0%)
		SrmB	284..>624	CDD:223587	104/398 (26%)
		P-loop_NTPase	<284..426	CDD:304359	49/150 (33%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	370..373		2/2 (100%)
		Helicase_C	493..609	CDD:278689	32/115 (28%)
		Necessary for interaction with HNRNPK. /evidence=ECO:0000250\|UniProtKB:Q92499	525..740		33/110 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010