DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and ddx31

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_031746553.1	Gene:	ddx31 / 100492953	XenbaseID:	XB-GENE-5831374	Length:	704	Species:	Xenopus tropicalis

Alignment Length:	835	Identity:	286/835 - (34%)
Similarity:	436/835 - (52%)	Gaps:	163/835 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LGDD-FMLNVTTKPV--VAQKAKPKITRAERLGKKQRQGKPLTKLSEEQITRALKSNKKPKNPNQ 179
            :||| .:||:|..|.  ..|:...|..:..:...:..:.|.:.:.|::     ......||.|
Frog     1 MGDDNLILNITQSPAPNSFQRGNSKFNKPHKHTGRWAKSKSVKRKSQD-----ASDEPSPKRP-- 58

  Fly   180 LPTPGDLFRAQLEEERRQKRREEGGGDQEASADEEDAKNNSGGGSPRVKPSSAVKESKKSSDIED 244
            :|...........:|:..|::|...|.......||:.|     |.|.||.||..|.:.:..||:
Frog    59 VPPTSQKRLRNAPDEKPYKKQEVPAGKVLDGKKEENPK-----GRPAVKTSSLFKNNPEVPDID- 117

  Fly   245 SGESGEESATSDEEPDESSAQSPGQEKEPKQTAKKPPKAEETSSTNRFRTKKIGLFDQSDVEALK 309
                                              :|
Frog   118 ----------------------------------RP----------------------------- 119

  Fly   310 QLGQRAVKPVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQT 374
                 |||.:||.:|:....|.||||||.|..:..::::...||||::|||.:|.|:||||||||
Frog   120 -----AVKQLKEKVFSADSFSDLGLHPHLVSTINTVMNMTNTTSVQKQTIPALLAGRDVLVRSQT 179

  Fly   375 GSGKTLAYALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGSLLG 439
            |||||:||.:|||:.||...|:|||.||..|||:||||||.:|::..||||:||:||||||.|:|
Frog   180 GSGKTMAYGVPLVQSLQGVTPKIQRSDGPYALVLVPTRELALQSFSTIQKLLKPFTWIVPGVLMG 244

  Fly   440 GESRKSEKARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVE 504
            ||.||||||||||||||||.|||||:||:..|.|...|:.::|::|||||:|::|:|:||..::.
Frog   245 GEKRKSEKARLRKGINILISTPGRLLDHIRSTKSIHFTRARWLVVDEADRILDMGFEKDVTAILN 309

  Fly   505 AIDKQRAECEDKELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKET 569
            |::.|   |:.:     |.:||||||:..|.:||.::|.:|:.:..:::...   :.|.|
Frog   310 ALNSQ---CQHR-----QNVLLSATLSPGVARLADISLNDPVSVTIAEDTNR---EDKHG----- 358

  Fly   570 IEALLEVDDGLGEYQEDV----TGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKA 630
                       |:.:||.    :...::||.|....||.|.||:||.|::.:..:...:.|. |.
Frog   359 -----------GKPKEDKKDGDSSCFAMPEKLHQHAVVAPSKLKLVTLAAFILGKWKCAKKP-KM 411

  Fly   631 IVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDS---DDDGDIPLLQGLRFFKLHGSMTQTE 692
            |||..:.|:|.|:|.:|::.||           .|||   .||          |.:|||:|.|.|
Frog   412 IVFFPSCELVEFYHSLLSKVLT-----------MGDSAMGPDD----------FLRLHGNMEQEE 455

  Fly   693 RQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLF 757
            |..||:.|..|.:.:||.|||..||:|:|.:..:||::.|.:.|:::||||||||.|.:|.::|.
Frog   456 RTEVFQQFTHCQAGILLCTDVAARGLDLPQVTWIVQFSAPASAAEYIHRVGRTARLGAQGSSLLI 520

  Fly   758 LTPSEAQFVRHLEKKRIRIQQGDMYAYLQTLLPKD-----------DEA---RTVQEAASNLQHK 808
            |.||||.:::.|.:.:|.:.:..|...|..||.:|           .||   :||:|.|:.||.|
Frog   521 LIPSEAAYLQTLAEHKISVSEMKMEDILSNLLMEDFLKIRRAGGKKSEAADPQTVRERATVLQTK 585

  Fly   809 FQTLLEDDRELHDKSCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPSKFAAKHA 873
            |:..:....:...::.||..|:::.|:|:||.||.||::|..|:||.||||.|::||...:.:
Frog   586 FEDYVHASADTALRAKKALQSYIRSYATYPKNLKHIFHIRSLHLGHVAKSFGLRDAPHSLSRQ-- 648

  Fly   874 APKAAPPTNRLTYTERDPEKIQA-QKRAKRRFTTTVSGEVRQ-LQQRDVGAQKPG 926
              .|..|:.:   ::..|::... :||:|:||:..:..|... |..:...|.|||
Frog   649 --LAGSPSKQ---SKGKPKRADTHKKRSKQRFSDLLRSEYASGLAPKPKKATKPG 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	14/81 (17%)
		P-loop_NTPase	332..548	CDD:304359	120/215 (56%)
		DEXDc	348..554	CDD:214692	113/205 (55%)
		HELICc	601..757	CDD:238034	60/158 (38%)
		DUF4217	805..866	CDD:290667	25/60 (42%)
ddx31	XP_031746553.1	Dob10	22..>185	CDD:226947	59/243 (24%)
		SrmB	130..616	CDD:223587	217/534 (41%)
		DEADc_DDX31	143..346	CDD:350707	114/210 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2637
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6389
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1820
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250484at33208
OrthoFinder	1	1.000	-	-		FOG0003502
OrthoInspector	1	1.000	-	-		oto103936
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160