DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and ddx51

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_002931939.2	Gene:	ddx51 / 100135117	XenbaseID:	XB-GENE-5837731	Length:	659	Species:	Xenopus tropicalis

Alignment Length:	731	Identity:	181/731 - (24%)
Similarity:	304/731 - (41%)	Gaps:	179/731 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 NQLPTPGDLFRAQLEEERRQ-KRREEGGGDQEASADEEDAKNNSGGGSPRVKPSSAVKESKKSSD 241
            :::.|..|..:|.|::...| |.|::.....:|.|..:|.........|.:  :..::::||...
Frog    12 DEVTTSEDRSKALLQKLHEQAKDRQQQRQHPKAKASPKDDHVEETNTKPSI--NETLRKTKKRKK 74

  Fly   242 IEDSGESGEESATSDEEPDESSAQSPGQEKEPKQTAKK--------------------------P 280
            .::..|.||..:.|||...:|..|.....||.|||.||                          |
Frog    75 KQEEEEEGELKSPSDENEQDSGQQEATCIKEKKQTKKKKKLIAEECNEVIEHISKNNEGSMAEEP 139

  Fly   281 PKAEETSSTNRFRTKKIGLFDQSDVE-ALKQLGQRAVKP------VKETIFTGSKISTLGLHPHA 338
            ..|:.|||..  .:..:|.|:...|| .|..|.|...:|      :|:.:.....|..  |||..
Frog   140 GGAKVTSSDP--SSILLGGFEPKSVEKVLPVLPQWLAQPSLVQKNIKQNLVPIHDIHC--LHPKV 200

  Fly   339 VKNLEDLLSIRELTSVQQKTIPEVLQ--------GK------DVLVRSQTGSGKTLAYALPLVE- 388
            :|.|| ...::.|..||.:.||.:|.        ||      ||.|.:.||||||||:.:|:|:
Frog   201 LKKLE-ANKVKYLFPVQAEVIPAILDSTCHGFLLGKGGYRPSDVCVSAPTGSGKTLAFVIPIVQA 264

  Fly   389 LLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGS-----LLGGESR--KSE 446
            |||:....::      |||::||:||.       |::.|.:...|.|.     ::.|:..  |.:
Frog   265 LLQRVVCEVR------ALVVLPTKELA-------QQVCKVFNTYVDGMGLKVVMVTGQKSFLKEQ 316

  Fly   447 KARLRKG-------INILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVE 504
            ::.:.|.       .:||:.||||||||:..|..|.|..|:||::|||||:::...:..:..:.:
Frog   317 ESLIHKTAFGFCSLADILVCTPGRLVDHIQQTEGFNLRHLRFLVIDEADRMIDSMNQDWLSHVTK 381

  Fly   505 AIDKQRAECED-----KE----------LPQ--LQRMLLSATLTSQVQQLAGLTLKNPLYIDNSD 552
            |:.:..|:..:     ||          |||  ||::|.|||||...::|..|.|..|....:.
Frog   382 AVFQVVADSPNMLFTRKEPGILTAASSCLPQTPLQKLLFSATLTQNPEKLKQLGLYQPRLFTSK- 445

  Fly   553 EAASAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLR---LVALS 614
                         ||.|.:     |....:.:...:|..|:||.  |::..:|..|.   |:.|.
Frog   446 -------------QKGTSD-----DSSETQMESSTSGNFSLPEG--LTHYYIPCNLNSKPLILLH 490

  Fly   615 SLLAKEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGL 679
            .||:       .:|..::..:.:...:....:|                         :....|:
Frog   491 FLLS-------LRFSRVLCFTNSRDASHRLYLL-------------------------VRSFGGI 523

  Fly   680 RFFKLHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGR 744
            ...:....::..||:...:.|......:|::||...||||:..:|.|:.|..||....:||||||
Frog   524 SVAEFSSRLSPGERKKTLKEFEQGKVQLLISTDATARGIDIKGVKCVINYDAPQFIRTYVHRVGR 588

  Fly   745 TARAGRKGRAVLFLTPSEAQFVRHLEKKRIRIQQGDMYAYL--------QTLLPKDDEARTVQEA 801
            |||||:.|.|...|               :::|:...::.|        |..|.|.:..:..::.
Frog   589 TARAGKAGLAFTML---------------LKVQENPYFSMLRDAGAPEMQKQLVKSENLKQYEQR 638

  Fly   802 ASNLQHKFQTLLEDDR 817
            ......:.|..::::|
Frog   639 YEEALIELQRAVKNER 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	23/107 (21%)
		P-loop_NTPase	332..548	CDD:304359	84/261 (32%)
		DEXDc	348..554	CDD:214692	78/251 (31%)
		HELICc	601..757	CDD:238034	37/158 (23%)
		DUF4217	805..866	CDD:290667	2/13 (15%)
ddx51	XP_002931939.2	DEADc_DDX51	200..443	CDD:350714	81/256 (32%)
ddx51	XP_002931939.2	SF2_C_DEAD	472..602	CDD:350174	38/161 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010