DRSC/TRiP Functional Genomics Resources

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Protein Alignment B-H1 and NKX2-1

DIOPT Version :10

Sequence 1:NP_523387.1 Gene:B-H1 / 32724 FlyBaseID:FBgn0011758 Length:544 Species:Drosophila melanogaster
Sequence 2:NP_001073136.1 Gene:NKX2-1 / 7080 HGNCID:11825 Length:401 Species:Homo sapiens


Alignment Length:462 Identity:122/462 - (26%)
Similarity:169/462 - (36%) Gaps:111/462 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 SGGSSPAHSNNNNNINGDNCEASNVAGVGVLPSALHHPQPHPPTHPHTHPHA-------LMHPHG 170
            ||||..|.          ..||:  ||....|..|...:....:..||.|.:       |...:.
Human     3 SGGSGKAR----------GWEAA--AGGRSSPGRLSRRRIMSMSPKHTTPFSVSDILSPLEESYK 55

  Fly   171 KLGHFPPTAGGNGLNVAQY--------AAAMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVAA 227
            |:|   ...||.|..:|.|        .||||||       |...:.|..||....||....::.
Human    56 KVG---MEGGGLGAPLAAYRQGQAAPPTAAMQQH-------AVGHHGAVTAAYHMTAAGVPQLSH 110

  Fly   228 PPVDGGVDGGVGLAPPAGGDLDDSSDYHEENEDCDSG------NMDDH--SVCSNGGKDDDGNSV 284
            ..|.|..:|.:       |::.:...|.:...:..||      |.|..  ::....|.....|..
Human   111 SAVGGYCNGNL-------GNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMS 168

  Fly   285 KSGSTSDMSGLSKK--------QRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDC 341
            ..|....:..:||.        :||.|..|:..|:..||:.|::|||||..||:.||..:.|:..
Human   169 GMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPT 233

  Fly   342 QVKTWYQNRRTKWKRQTAVGLELLAEAGNFAAFQRLYGGSPYLGAWPYAAAAGAAHGATPHTNID 406
            |||.|:||.|.|.|||          |.:.||.|:|...|          ..|...|.|......
Human   234 QVKIWFQNHRYKMKRQ----------AKDKAAQQQLQQDS----------GGGGGGGGTGCPQQQ 278

  Fly   407 IYYRQAAAAAAMQ------KPLPYNLYAGVPSVGVGVGVGVGPAPFSHLSASSSLSSLSSYYQSA 465
            ...:|:....|:.      ||    ..||.|:.|.....|.......|.:.::         |:|
Human   279 QAQQQSPRRVAVPVLVKDGKP----CQAGAPAPGAASLQGHAQQQAQHQAQAA---------QAA 330

  Fly   466 AAAASAANPG---GPHPVAPPPSVGGGSPPSGLVKPIPAHSASASPPPRPPSTPSPTLNPGSPPG 527
            |||.|..:.|   |.||...|.| .|.||      .:..|:||.:......|:.|...:.||..|
Human   331 AAAISVGSGGAGLGAHPGHQPGS-AGQSP------DLAHHAASPAALQGQVSSLSHLNSSGSDYG 388

  Fly   528 RSVDSCS 534
            ..  |||
Human   389 TM--SCS 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
B-H1NP_523387.1 Homeodomain 300..356 CDD:459649 26/55 (47%)
NKX2-1NP_001073136.1 Homeodomain 192..248 CDD:459649 26/55 (47%)

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