Protein Alignment B-H1 and Nkx1-1

DIOPT Version :10

• Sequence 1: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_035450.1
• Gene: Nkx1-1 / 672284
• MGIID: 109346
• Length: 440
• Species: Mus musculus
• Alignment Length: 470
• Identity: 124/470 - (26%)
• Similarity: 156/470 - (33%)
• Gaps: 160/470 - (34%)

  Fly   135 SNVAGVGVLPSALHHPQPHP-----PTHPHTHPHALMHPHGKLGHFPPTAGGNGLNVAQYAAAMQ 194
            |..|..|.:| ||..|.|.|     |..|.......|....:|..| |.||...|..:....|:.
Mouse     4 SGPAAPGDVP-ALPPPPPGPGSGPAPPAPAATARDTMDGRAELPIF-PRAGVPPLAASDTVPAVP 66

  Fly   195 QHYAAAAAAAAARNNA------------------------AAAAAAAAAAAAAGVAAPPVDG--- 232
            :...||..||..|..:                        ...|..|..|.||.||.|...|
Mouse    67 EGAGAARPAAPPRPTSFSVLDILDPNKFNSRRRRCVLLGPVVPATCAPCAPAACVAVPAASGRSP 131

  Fly   233 -------------GVDGGVGLAPPAGGD--------------------LDDSSDYHEENED---- 260
                         ||....|..|.:.||                    ..||.|...|:||
Mouse   132 RAELERRALSAATGVAAAAGAEPTSAGDSYRADEAEANGYSSGSGRSPTADSEDEAPEDEDEEEA 196

  Fly   261 -------------------------C------DSGNMDDHSV-------------------CSNG 275
                                     |      ::..:||.:.                   ..:.
Mouse   197 PEVQDAQGTEEPRGGSGGLGARGSGCPGAAEVEASPVDDTAAPGPRGNSPGAPGPPATATGAGSA 261

  Fly   276 GKDDDGNSV-------KSGSTSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELA 333
            |....|.:|       ::||.|.    |.|.|:||||||..||..||..|:..:||||.||..||
Mouse   262 GSTPQGAAVTTKPKRKRTGSDSK----SGKPRRARTAFTYEQLVALENKFKATRYLSVCERLNLA 322

  Fly   334 HKLDLSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNFAAFQRLYGGSPYLGAWPYAAAAGAAHG 398
            ..|.|::.|||.|:||||||||:|.. |.:..|..|.        ||.|..||.|   .||...|
Mouse   323 LSLSLTETQVKIWFQNRRTKWKKQNP-GADTSAPTGG--------GGGPGPGAGP---GAGLPGG 375

  Fly   399 ATPHTNIDIYYRQAAAAAAMQKPLPYNLYAGVPSVGVGVGVGVGPAPFSHLSASSSLSSLSSYYQ 463
            .:|          .:.:..|..||..:..||.|:...|..|.....||  ||:.:.||......|
Mouse   376 LSP----------LSPSPPMGAPLALHGPAGYPAHSPGGLVCAAQLPF--LSSPAVLSPFVLGSQ 428

  Fly   464 SAAAAASAANPGGPH 478
            :..|.|..|    ||
Mouse   429 TYGAPAFYA----PH 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	33/55 (60%)
Nkx1-1	NP_035450.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		24/79 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..291		24/149 (16%)
		Homeodomain	289..345	CDD:459649	33/55 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..387		18/66 (27%)