DRSC/TRiP Functional Genomics Resources

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Protein Alignment B-H1 and NKX2-4

DIOPT Version :10

Sequence 1:NP_523387.1 Gene:B-H1 / 32724 FlyBaseID:FBgn0011758 Length:544 Species:Drosophila melanogaster
Sequence 2:NP_149416.1 Gene:NKX2-4 / 644524 HGNCID:7837 Length:354 Species:Homo sapiens


Alignment Length:391 Identity:101/391 - (25%)
Similarity:136/391 - (34%) Gaps:135/391 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 PHALMHPHGKLGHF---PPTAGGNGLNVA--QYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAAA 221
            |..|..|.|....:   ||........||  |.:.||..|.||||||||    ||||||||....
Human    35 PPGLGAPLGAAAAYRAPPPGPSSQAATVAGMQPSHAMAGHNAAAAAAAA----AAAAAAAATYHM 95

  Fly   222 AAGVAAPP-------VDGGVDGGVGLAPP-----AGGDLDDSSDYHEENEDCDSGNMDDH----- 269
            ..||:..|       .:||: |.:|..|.     .||   .::.::..|.|....::...     
Human    96 PPGVSQFPHGAMGSYCNGGL-GNMGELPAYTDGMRGG---AATGWYGANPDPRYSSISRFMGPSA 156

  Fly   270 --SVCSNGGKDDDGNSVKS-GSTSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQE 331
              :|...|......::.|| |.....:..:..:||.|..|:..|:..||:.|::|||||..||:.
Human   157 GVNVAGMGSLTGIADAAKSLGPLHAAAAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREH 221

  Fly   332 LAHKLDLSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNFAAFQRLYGGSPYLGAWPYAAAAGAA 396
            ||..:.|:..|||.|:||.|.|.|||.                                      
Human   222 LASMIHLTPTQVKIWFQNHRYKMKRQA-------------------------------------- 248

  Fly   397 HGATPHTNIDIYYRQAAAAAAMQKPLPYNLYAGVPSVGVGVGVGVGPAPFSHLSASSSLSSLSSY 461
                         :..||....|:.                  |:||.|                
Human   249 -------------KDKAAQQLQQEG------------------GLGPPP---------------- 266

  Fly   462 YQSAAAAASAANPGGPHPVAPPPSVGGGSP-PSGLVKPIPAHSASASPPPRPPS-TPSPTLNPGS 524
                      ..|..|..||.|..|..|.| .:|...|.|..:.     |:||: ||:|.|...|
Human   267 ----------PPPPSPRRVAVPVLVKDGKPCQNGASTPTPGQAG-----PQPPAPTPAPELEELS 316

  Fly   525 P 525
            |
Human   317 P 317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
B-H1NP_523387.1 Homeodomain 300..356 CDD:459649 26/55 (47%)
NKX2-4NP_149416.1 Homeodomain 190..246 CDD:459649 26/55 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..329 29/172 (17%)

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