Protein Alignment B-H1 and NKX3-1

DIOPT Version :10

• Sequence 1: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_006158.2
• Gene: NKX3-1 / 4824
• HGNCID: 7838
• Length: 234
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 76/351 - (21%)
• Similarity: 110/351 - (31%)
• Gaps: 157/351 - (44%)

  Fly    66 ASGIGKPNRSR----FMINDILAGSAAAAFYKQQQHHQQLHHHNNNNNSGSSGGSSPAHSNNNNN 126
            |.|...|..|:    |:|.|||...|      |:|                 ||.:.:....:
Human    14 AEGAAPPTPSKPLTSFLIQDILRDGA------QRQ-----------------GGRTSSQRQRD-- 53

  Fly   127 INGDNCEASNVAGVGVLPSALHHPQPHPPTHPHTHPHALMHPHGKLGHFPPTAGGNGLNVAQYAA 191
                                   |:|.|...|.                    ||.
Human    54 -----------------------PEPEPEPEPE--------------------GGR--------- 66

  Fly   192 AMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVAAPPVDGGVDGGVGLAPPAGGDLDDSSDYHE 256
                      :.|.|:|:..:....||...|..:|                      :...:.|.
Human    67 ----------SRAGAQNDQLSTGPRAAPEEAETLA----------------------ETEPERHL 99

  Fly   257 ENEDCDSGNMDDHSVCSNGGKDDDGNSVKSGSTSDMSGLSKK-QRKARTAFTDHQLQTLEKSFER 320
            .:...||.|                   .||:...:....|: |:::|.||:..|:..||:.|..
Human   100 GSYLLDSEN-------------------TSGALPRLPQTPKQPQKRSRAAFSHTQVIELERKFSH 145

  Fly   321 QKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNF-----------AAF 374
            |||||..||..||..|.|::.|||.|:||||.|.||:     :|.:|.|:.           .||
Human   146 QKYLSAPERAHLAKNLKLTETQVKIWFQNRRYKTKRK-----QLSSELGDLEKHSSLPALKEEAF 205

  Fly   375 QR-----LYGGSPYLGAWPYAAAAGA 395
            .|     :|...||   :||....|:
Human   206 SRASLVSVYNSYPY---YPYLYCVGS 228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	27/55 (49%)
NKX3-1	NP_006158.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131		36/244 (15%)
		Homeodomain	125..181	CDD:459649	27/55 (49%)