Protein Alignment B-H1 and EVX2

DIOPT Version :10

• Sequence 1: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001073927.1
• Gene: EVX2 / 344191
• HGNCID: 3507
• Length: 476
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 128/452 - (28%)
• Similarity: 177/452 - (39%)
• Gaps: 123/452 - (27%)

  Fly   114 GGSSPAHSNNNNNINGDNCEASNVAGVGVLPSALHHPQPHPPTHPHTHPHALMHPHGKLGHFPPT 178
            |..||......:|:       ||.||..|| .||.:.| ||.......|.|.:  |..||..|..
Human    15 GLHSPTAGKRFSNL-------SNSAGNAVL-EALENSQ-HPARLSPRLPSAPL--HSALGELPAK 68

  Fly   179 -------------AGGNGLNVAQYAAAMQQ-----HYAAAAAAAAARNNAAAAAAAAAAAAAAGV 225
                         .|......::.::|.:.     ||:.|||.|...::.....:|..:....|.
Human    69 GKFEIDTLFNLQHTGSESTVSSEISSAAESRKKPGHYSEAAAEADMSSDVEVGCSALRSPGGLGA 133

  Fly   226 AAPPVDGGVDGGVGLAPPAGGDLDDSSDYHEENEDCDSGNMDDHSVCSNGGKDDDGNSVK---SG 287
            |....:.|  .|...:..|.|....:|         .||....|     ||....|.|..   ||
Human   134 AQLKENNG--KGYAESGSAAGTTTSAS---------GSGLGSLH-----GGSGGSGGSAALGGSG 182

  Fly   288 STSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRT 352
            |.:|      :.|:.|||||..|:..|||.|.|:.|:|...|.|||..|:|.:..:|.|:||||.
Human   183 SGAD------QVRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRM 241

  Fly   353 KWKRQTAVGLELLAEAGNFAAFQRLY----------GGSPY-------LGAWPY-----AAAAGA 395
            |.|||.      ||.:....|....|          |..||       |..:|:     ||||.|
Human   242 KDKRQR------LAMSWPHPADPSFYTYMMTHAAATGSLPYPFHSHVPLHYYPHVGVTAAAAAAA 300

  Fly   396 AHGATPHTNIDIYYRQAAAA----AAMQKPL--------PYNLYAGVPSVGVGV---GVGVGPAP 445
            |.||            ||||    |...:||        ||:.    |.:....   |:...||.
Human   301 ASGA------------AAAASSPFATSIRPLDTFRALSHPYSR----PELLCSFRHPGLYQAPAA 349

  Fly   446 FSHLSASSSLSSLSSYYQSAAAAASAANPGGPHPVAPPPSVGGGSPPSGLVKPIPAHSASAS 507
            .:.|::::|.::.::   :||||||:|...|    |||   .|||.|...:....:.||:|:
Human   350 AAGLNSAASAAAAAA---AAAAAASSAAAAG----APP---SGGSAPCSCLSCHSSQSAAAA 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	27/55 (49%)
EVX2	NP_001073927.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..113		7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..185		14/56 (25%)
		Homeodomain	189..245	CDD:459649	27/55 (49%)