DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment B-H1 and BARHL2

DIOPT Version :9

Sequence 1:	NP_523387.1	Gene:	B-H1 / 32724	FlyBaseID:	FBgn0011758	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_064447.1	Gene:	BARHL2 / 343472	HGNCID:	954	Length:	387	Species:	Homo sapiens

Alignment Length:	440	Identity:	147/440 - (33%)
Similarity:	190/440 - (43%)	Gaps:	129/440 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GSSGGS-------SPAHSNNNNNINGD-----------------NCEASNVAGVGVLPSA----- 146
            |:||.|       |.|.|.:...:|||                 ....|.:..||..||:
Human     5 GASGSSFGIDTILSSASSGSPGMMNGDFRPLGEARTADFRSQATPSPCSEIDTVGTAPSSPISVT 69

  Fly   147 LHHPQPH---PPTHPHTHPHALMHPHGKLGHFPPTAGG-----NGLNVAQYAAAMQQ-----HYA 198
            :..|:||   ..|..|.|.|....|       ||.|..     ..|...|.....||     ...
Human    70 MEPPEPHLVADATQHHHHLHHSQQP-------PPPAAAPTQSLQPLPQQQQPLPPQQPPPPPPQQ 127

  Fly   199 AAAAAAAARNNAA----------AAAAAAAAAAAAGVAAP---PVDGGVDGGVGLAPPAGGDLDD 250
            ..:||:|.|.:.:          :...||.|..:..|::|   |                  ..:
Human   128 LGSAASAPRTSTSSFLIKDILGDSKPLAACAPYSTSVSSPHHTP------------------KQE 174

  Fly   251 SSDYHE------ENEDCDS---GNMDDHSVCSNGGKDDDGNSVKSGSTSDMSGLSKKQRKARTAF 306
            |:..||      |.||..:   ...|..|.....|..::|:...:.|.......:||.|||||||
Human   175 SNAVHESFRPKLEQEDSKTKLDKREDSQSDIKCHGTKEEGDREITSSRESPPVRAKKPRKARTAF 239

  Fly   307 TDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNF 371
            :||||..||:|||||||||||:|.:||..|:|:|.|||||||||||||||||||||||||||||:
Human   240 SDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNY 304

  Fly   372 AAFQRLYGGSPY------LGAWPYAAAAGAAHGATPHTNIDIYYRQAAAAAAMQKPLPYNLYAGV 430
            :|.||:: .|||      ||:.....||.||  |..:::  :|....|....:|:||       |
Human   305 SALQRMF-PSPYFYHPSLLGSMDSTTAAAAA--AAMYSS--MYRTPPAPHPQLQRPL-------V 357

  Fly   431 PSVGV-GVGVGVGPAPFSHLSASSSLSSLSSYYQSAAAAASAANPGGPHP 479
            |.|.: |:|.|..||          |:.|||           ..||.|||
Human   358 PRVLIHGLGPGGQPA----------LNPLSS-----------PIPGTPHP 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeobox	303..355	CDD:278475	39/51 (76%)
BARHL2	NP_064447.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..145		34/146 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..240		23/100 (23%)
		Homeobox	236..288	CDD:278475	39/51 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..387		12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142901
Domainoid	1	1.000	103	1.000	Domainoid score	I6767
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4383
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002353
OrthoInspector	1	1.000	-	-		mtm8464
orthoMCL	1	0.900	-	-		OOG6_109676
Panther	1	1.100	-	-	O	PTHR24330
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10747
SonicParanoid	1	1.000	-	-		X1387
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780