Protein Alignment B-H1 and HOXB3

DIOPT Version :10

• Sequence 1: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: XP_016880049.1
• Gene: HOXB3 / 3213
• HGNCID: 5114
• Length: 578
• Species: Homo sapiens
• Alignment Length: 449
• Identity: 115/449 - (25%)
• Similarity: 158/449 - (35%)
• Gaps: 147/449 - (32%)

  Fly   112 SSGGSSPAHSNNNNNINGDNCEASNVAGVGVLPSALHHPQPHPPTHPHTHPHALMHPHGKLGHFP 176
            |.|.::| |: .:..:|| :|...     |:.|..|..|...||  |...|.:.. .:...|..|
Human   203 SLGNAAP-HA-KSKELNG-SCMRP-----GLAPEPLSAPPGSPP--PSAAPTSAT-SNSSNGGGP 256

  Fly   177 PTAG----GNGLN---VAQYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVAAPPVDGGV 234
            ..:|    |.|.|   ..|....|::    :...:..:||:...|.........|      .||.
Human   257 SKSGPPKCGPGTNSTLTKQIFPWMKE----SRQTSKLKNNSPGTAEGCGGGGGGG------GGGG 311

  Fly   235 DGGVGLAPPAGGDLDDSSDYHEENEDCDSGNMDDHSVCSNGGKDDDGNSVKSGSTSDMSGLSKKQ 299
            .||.|     ||                            ||....|:....||.:        .
Human   312 SGGSG-----GG----------------------------GGGGGGGDKSPPGSAA--------S 335

  Fly   300 RKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKR-QTAVGLE 363
            ::||||:|..||..|||.|...:||....|.|:|:.|:||:.|:|.|:||||.|:|: |.|.|
Human   336 KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKG-- 398

  Fly   364 LLAEAGNFAAFQRLYGGSPYLGAWPYAAAAG---AAHGATPHTNIDIYYRQAAAAAAMQKPLP-- 423
            |.:.:|..:.     .|||   ..|..:.||   |.|..||               :.:.|.|
Human   399 LASSSGGPSP-----AGSP---PQPMQSTAGFMNALHSMTP---------------SYESPSPPA 440

  Fly   424 -----YNLYAGVPS------VGVGVGVGVGPAPFSHLSASSSLSSLSSYYQSAAAAASAANPGGP 477
                 .|.|| :||      .|.|......|.|             :..|:.....|:....|.|
Human   441 FGKAHQNAYA-LPSNYQPPLKGCGAPQKYPPTP-------------APEYEPHVLQANGGAYGTP 491

  Fly   478 HPVAPPPSVGGGSPPSGLVKPIPAHSASASPPPRPPST---------PSPTLN-PGSPP 526
            .....|..||||    |...|:        |||..||.         ||..|: .|:||
Human   492 TMQGSPVYVGGG----GYADPL--------PPPAGPSLYGLNHLSHHPSGNLDYNGAPP 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	27/55 (49%)
HOXB3	XP_016880049.1	Homeodomain	336..392	CDD:459649	27/55 (49%)
		DUF4074	513..576	CDD:463833	8/26 (31%)