Protein Alignment B-H1 and HMX1

DIOPT Version :10

• Sequence 1: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_061815.2
• Gene: HMX1 / 3166
• HGNCID: 5017
• Length: 348
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 110/482 - (22%)
• Similarity: 155/482 - (32%)
• Gaps: 186/482 - (38%)

  Fly    65 TASGIGKPNR-SRFMINDILAGSAAAAFYKQQQHHQQLHHHNNNNNSGSSGGSSPAHSNNNNNIN 128
            |..|...|.| |.|:|.::||..|..|                 ..:....||......::::..
Human     6 TEPGRATPARASSFLIENLLAAEAKGA-----------------GRATQGDGSREDEEEDDDDPE 53

  Fly   129 GDNCEASN----------VAGVG----------VLPSALH-HPQPHPPTHPHTHPHAL------- 165
            .::.|.:.          :||.|          :.|.||. .|:|.|...|   |.||
Human    54 DEDAEQARRRRLQRRRQLLAGTGPGGEARARALLGPGALGLGPRPPPGPGP---PFALGCGGAAR 115

  Fly   166 MHP--HGKLGH--FPPTAGGNGLNVAQYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAA----AA 222
            .:|  ||..|.  .|.|:..:.....:.....:..:.......|.:..||..||...||    |:
Human   116 WYPRAHGGYGGGLSPDTSDRDSPETGEEMGRAEGAWPRGPGPGAVQREAAELAARGPAAGTEEAS 180

  Fly   223 AGVAAPPVDGGVDGGVGLAPPAGGDLDDSSDYHEENEDCDSGNMDDHSVCSNGGKDDDGNSVKSG 287
            .....|...|...||||:                                 .||
Human   181 ELAEVPAAAGETRGGVGV---------------------------------GGG----------- 201

  Fly   288 STSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRT 352
                      :::|.||.|:..|:..||.:|:.::|||..||..||..|.|::.|||.|:||||.
Human   202 ----------RKKKTRTVFSRSQVFQLESTFDLKRYLSSAERAGLAASLQLTETQVKIWFQNRRN 256

  Fly   353 KWKRQTAVGLELLAEAGNFAAFQRLYGGSPYLGAWPYAAAAGAAHGATPHTNIDIYYRQAAAAAA 417
            |||||.|..||                           ||:.:..||.....:.:.|.::..|||
Human   257 KWKRQLAAELE---------------------------AASLSPPGAQRLVRVPVLYHESPPAAA 294

  Fly   418 MQKPLPYNLYAGVPSVGVGVGVGVGPAPFSHLSASSSLSSLSSYYQSAAAAASAANPGGPHPVAP 482
            .         ||.|:.          .||                           |..|...||
Human   295 A---------AGPPAT----------LPF---------------------------PLAPAAPAP 313

  Fly   483 PPSVGGGSPPSGLVKPIPAHSASASPP 509
            ||.:.|.|  ..|..|:.|..|:||.|
Human   314 PPPLLGFS--GALAYPLAAFPAAASVP 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	27/55 (49%)
HMX1	NP_061815.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..203		40/247 (16%)
		Homeodomain	206..260	CDD:459649	26/53 (49%)
		HMX family specific domain 1	263..273		5/36 (14%)
		HMX family specific domain 2	276..289		2/12 (17%)