Protein Alignment B-H1 and MNX1

DIOPT Version :10

• Sequence 1: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_005506.3
• Gene: MNX1 / 3110
• HGNCID: 4979
• Length: 401
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 134/547 - (24%)
• Similarity: 162/547 - (29%)
• Gaps: 231/547 - (42%)

  Fly    42 LQPPAVAHS----IHSTTTMSSGGSTTTASGIGKPNRSRFMINDILAGSAAAAFYKQQQHHQQLH 102
            :.||..|.:    :...|::::..|.|...|.|              |.|
Human    15 VDPPRAASAQSAPLALVTSLAAAASGTGGGGGG--------------GGA--------------- 50

  Fly   103 HHNNNNNSGSSGGSSPAHSNNNNNINGDNCEASNVAGVGVLPSA----LHHPQPHPPTHPHTHPH 163
                  :.|:||..|||.|..                    |:|    |....|.||.....|..
Human    51 ------SGGTSGSCSPASSEP--------------------PAAPADRLRAESPSPPRLLAAHCA 89

  Fly   164 ALMHPH--GKLGHFPPTAGGNGLNVAQYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVA 226
            .|..|.  |..|....|.||:|         ...|:|...|       |||||||||||||.|:|
Human    90 LLPKPGFLGAGGGGGGTGGGHG---------GPHHHAHPGA-------AAAAAAAAAAAAAGGLA 138

  Fly   227 APPVDGGVDGGVGLAPPAGGDLDDSSDYHEENEDCDSGNMDDHSVCSNGGKDDDG-------NSV 284
            .....||..||.||  ||...|.....|........:.....|...|.......|       :.:
Human   139 LGLHPGGAQGGAGL--PAQAALYGHPVYGYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPI 201

  Fly   285 KSG------------STSDM-------------SGLSKKQRKARTAFTDHQLQTLEKSFERQKYL 324
            |.|            ||:.|             |.|..|.|:.|||||..||..||..|:..|||
Human   202 KLGAGTFQLDQWLRASTAGMILPKMPDFNSQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYL 266

  Fly   325 SVQERQELAHKLDLSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNFAAFQRLYGGSPYLGAWPY 389
            |..:|.|:|..|.|::.|||.|:||||.||||....
Human   267 SRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKA----------------------------- 302

  Fly   390 AAAAGAAHGATPHTNIDIYYRQAAAAAAMQKPLPYNLYAGVPSVGVGVGVGVGPAPFSHLSASSS 454
                               ..|||..|..||             |.|.|.|.|
Human   303 -------------------KEQAAQEAEKQK-------------GGGGGAGKG------------ 323

  Fly   455 LSSLSSYYQSAAAAASAANPGGPHPVAPPP--SVGGGSPPSGLVKPIP----------------- 500
                           .|..||....:.||.  ..|.|.....|....|
Human   324 ---------------GAEEPGAEELLGPPAPGDKGSGRRLRDLRDSDPEEDEDEDDEDHFPYSNG 373

  Fly   501 --AHSASA-------SPPPRPPSTPSP 518
              .|:||:       ||||||...|:|
Human   374 ASVHAASSDCSSEDDSPPPRPSHQPAP 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	30/55 (55%)
MNX1	NP_005506.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..78		16/95 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..120		7/27 (26%)
		Homeodomain	242..298	CDD:459649	30/55 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	299..401		31/190 (16%)