DRSC/TRiP Functional Genomics Resources

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Protein Alignment B-H1 and EN2

DIOPT Version :10

Sequence 1:NP_523387.1 Gene:B-H1 / 32724 FlyBaseID:FBgn0011758 Length:544 Species:Drosophila melanogaster
Sequence 2:NP_001418.2 Gene:EN2 / 2020 HGNCID:3343 Length:333 Species:Homo sapiens


Alignment Length:363 Identity:91/363 - (25%)
Similarity:133/363 - (36%) Gaps:105/363 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 NDILAGSAAAAFYKQQQHHQQLHHHNNNNNSGSSGGSSPAHSNNNNNINGDNCEASNVAGVGVLP 144
            ||...|.||||...|:|...     :....||..|||||..::....            ...:||
Human     4 NDPKPGEAAAAVEGQRQPES-----SPGGGSGGGGGSSPGEADTGRR------------RALMLP 51

  Fly   145 SALHHPQPHPPTHPHTHPHA--------LMHPH----------------GKLGHFPPTAGGNGLN 185
            :.|..|      ..|.|||.        ::.|.                |:.|......|.:|..
Human    52 AVLQAP------GNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGGRGGGAGGEGGASGAE 110

  Fly   186 VAQYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVAAP---------------------- 228
            ....|...:|  ...:.:...|.|...|..|.....|||..:|                      
Human   111 GGGGAGGSEQ--LLGSGSREPRQNPPCAPGAGGPLPAAGSDSPGDGEGGSKTLSLHGGAKKGGDP 173

  Fly   229 --PVDGGVDG-GVGLAPPAGGDLDDSSDYHEENEDCDSG-NMDDHSV-------CSNGGKDDDGN 282
              |:||.:.. |:|     ||||..|||    ::...:| |:....:       |:.  ..|..:
Human   174 GGPLDGSLKARGLG-----GGDLSVSSD----SDSSQAGANLGAQPMLWPAWVYCTR--YSDRPS 227

  Fly   283 SVKSGSTSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWY 347
            |............:|:.::.|||||..|||.|:..|:..:||:.|.||.||.:|.|::.|:|.|:
Human   228 SGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWF 292

  Fly   348 QNRRTKWKRQT----AVGLELLAEAGNFAAFQRLYGGS 381
            ||:|.|.|:.|    .:.:.|:|        |.||..|
Human   293 QNKRAKIKKATGNKNTLAVHLMA--------QGLYNHS 322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
B-H1NP_523387.1 Homeodomain 300..356 CDD:459649 26/55 (47%)
EN2NP_001418.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..49 16/61 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..206 27/121 (22%)
homeobox domain 243..302 27/58 (47%)
Homeodomain 245..301 CDD:459649 26/55 (47%)
Engrail_1_C_sig 302..332 CDD:431338 7/29 (24%)

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