DRSC/TRiP Functional Genomics Resources

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Protein Alignment B-H1 and Nkx6-1

DIOPT Version :10

Sequence 1:NP_523387.1 Gene:B-H1 / 32724 FlyBaseID:FBgn0011758 Length:544 Species:Drosophila melanogaster
Sequence 2:NP_659204.1 Gene:Nkx6-1 / 18096 MGIID:1206039 Length:365 Species:Mus musculus


Alignment Length:350 Identity:94/350 - (26%)
Similarity:145/350 - (41%) Gaps:81/350 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PNRSRFMINDILAGSAAAAFYKQQQHHQQLH-----------HHNNNNNSGSSGGSSPAHSNNNN 125
            |.:|.|    :|:....||.:...:....|:           ..:::::|.||..|.|..|:|..
Mouse    10 PRQSAF----LLSSPPLAALHSMAEMKTPLYPAAYPPLPTGPPSSSSSSSSSSSPSPPLGSHNPG 70

  Fly   126 NINGDNCEASNVAGVGVLPSALHHPQPH-------PPTHPHTHPHALMHPHGKLGHFPPTAGGNG 183
            .:...  .|..::.:|..|..|....||       .|:.|.....||           |:|..:|
Mouse    71 GLKPP--AAGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAAL-----------PSASPSG 122

  Fly   184 LNVAQYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVAA-----------PPVDG----- 232
            .:.:..::|.    |.:|:||||   ||||||||||::.||:.|           ||..|     
Mouse   123 SSSSSSSSAS----ATSASAAAA---AAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSP 180

  Fly   233 --GVDGGVGLAPPAGGDLDDSSDYHEENEDCDSGNMDDHSVCS-NGGK---DDDGNSVKSGSTSD 291
              .....||..|....:|...:..............|....|: :.|.   |.||          
Mouse   181 SAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDG---------- 235

  Fly   292 MSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKR 356
                  |::..|..|:..|:..|||:||:.|||:..||..||:.|.:::.|||.|:|||||||::
Mouse   236 ------KRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRK 294

  Fly   357 QTAVGLELLAEAGNFAAFQRLYGGS 381
            :.|..: ..|:....:..:||.|.|
Mouse   295 KHAAEM-ATAKKKQDSETERLKGTS 318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
B-H1NP_523387.1 Homeodomain 300..356 CDD:459649 27/55 (49%)
Nkx6-1NP_659204.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..136 23/117 (20%)
Repressor domain. /evidence=ECO:0000250 102..269 54/200 (27%)
Homeodomain 236..294 CDD:459649 28/57 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..365 5/24 (21%)
Involved in DNA-binding. /evidence=ECO:0000250 307..365 3/11 (27%)

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