Protein Alignment B-H1 and DLX2

DIOPT Version :10

• Sequence 1: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_004396.1
• Gene: DLX2 / 1746
• HGNCID: 2915
• Length: 328
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 108/434 - (24%)
• Similarity: 154/434 - (35%)
• Gaps: 155/434 - (35%)

  Fly    87 AAAAFYKQQQHHQQLHHHNNNNNSGSSGGSSPAHSNNNNNINGDNCEASNVAGVGVLPSALHHPQ 151
            ||::.|.|   |||         ..|.||:.|          |.|..:|         |:||.||
Human    18 AASSTYHQ---HQQ---------PPSGGGAGP----------GGNSSSS---------SSLHKPQ 51

  Fly   152 PHPPTHP---------HTHPHALMHPHGKLGHFPPTAGGNGLNVAQYAAAMQQHYAAAAAAAAAR 207
             ..||.|         :|:.   .||          |||.|...:.||     |..:....|:..
Human    52 -ESPTLPVSTATDSSYYTNQ---QHP----------AGGGGGGGSPYA-----HMGSYQYQASGL 97

  Fly   208 NNAAAAA---------AAAAAAAAAGVAAPPVDGGVDGGVGLAPPAGGDLDDSSDYHEENEDCDS 263
            ||...:|         ||..:.|..|.::.|.:.                      ..|.||.:.
Human    98 NNVPYSAKSSYDLGYTAAYTSYAPYGTSSSPANN----------------------EPEKEDLEP 140

  Fly   264 GNMDDHSVCSNGGKDDDGNSVKSGSTSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQE 328
                                    ....::|..||.||.||.::..||..|::.|::.:||::.|
Human   141 ------------------------EIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPE 181

  Fly   329 RQELAHKLDLSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNFAAFQRLYGGSPYLGAWPYAAAA 393
            |.|||..|.|:..|||.|:||||:|:|:....| |:.:|....|:      .||...:.|.:|.|
Human   182 RAELAASLGLTQTQVKIWFQNRRSKFKKMWKSG-EIPSEQHPGAS------ASPPCASPPVSAPA 239

  Fly   394 GAAHGATPHTNIDIYYRQAAAAAAMQKPLPYNLYAGVPSVGVGVGVGVGPAPFSHLSASSSLSSL 458
            ....|                       :|..: ||....|.| |.|.|.:..|..||:|:....
Human   240 SWDFG-----------------------VPQRM-AGGGGPGSG-GSGAGSSGSSPSSAASAFLGN 279

  Fly   459 SSYYQSAAAAASAANPGGP--HPVAPPP-------SVGGGSPPS 493
            ..:|...:.:||......|  ||...|.       ..|||:|.|
Human   280 YPWYHQTSGSASHLQATAPLLHPTQTPQPHHHHHHHGGGGAPVS 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	26/55 (47%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..81		29/107 (27%)
		DLL_N	51..132	CDD:463567	23/121 (19%)
		Homeodomain	153..209	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..270		19/90 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..328		8/24 (33%)