Protein Alignment B-H1 and Hoxb13

DIOPT Version :10

• Sequence 1: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_032293.1
• Gene: Hoxb13 / 15408
• MGIID: 107730
• Length: 286
• Species: Mus musculus
• Alignment Length: 288
• Identity: 63/288 - (21%)
• Similarity: 107/288 - (37%)
• Gaps: 68/288 - (23%)

  Fly   111 GSSGGSSPAHSNNNNNINGDNCEASNVAGVGVLPSALHHP-----QPHPPTHPHTHPHALMHPHG 170
            |:.||        .|.::..:..||:.|...::|:..:.|     ...||...|..|..   |.|
Mouse    20 GAGGG--------RNLVSHSSPLASHPAAPTLMPTVNYAPLDLPGSAEPPKQCHPCPGV---PQG 73

  Fly   171 ------KLGHFPPTAGGNGLNVAQYAAAMQQHYAAAAAAAAARNNAAAAAAAA--AAAAAAGVAA 227
                  ..|:|     |.|            :|:...:.::.:..|..||.|.  :...|.|...
Mouse    74 ASPAPVPYGYF-----GGG------------YYSCRVSRSSLKPCAQTAALATYPSETPAPGEEY 121

  Fly   228 P--PVD-GGVDGGVGLAPPAGGDLDDS---------SDYHEENEDCDS-------GNMDDHSVCS 273
            |  |.: ....|..|...|....||.|         ...|:.....||       |..:. .:|.
Mouse   122 PSRPTEFAFYPGYPGPYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQPWALAGGWNS-QMCC 185

  Fly   274 NGGKDDDGNSVKSGSTSDM------SGLS-KKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQE 331
            .|.::..|...|:......      .|.: ::.||.|..::..||:.||:.:...|:::..:|::
Mouse   186 QGEQNPPGPFWKAAFAEPSVQHPPPDGCAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRK 250

  Fly   332 LAHKLDLSDCQVKTWYQNRRTKWKRQTA 359
            ::....||:.|:..|:||||.|.|:..|
Mouse   251 ISAATSLSERQITIWFQNRRVKEKKVLA 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	18/55 (33%)
Hoxb13	NP_032293.1	HoxA13_N	12..124	CDD:463521	27/131 (21%)
		Homeodomain	219..275	CDD:459649	18/55 (33%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q92826	219..248		8/28 (29%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q92826	260..275		7/14 (50%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q92826	272..275		1/2 (50%)