Protein Alignment B-H1 and Hmx1

DIOPT Version :10

• Sequence 1: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_034575.1
• Gene: Hmx1 / 15371
• MGIID: 107178
• Length: 332
• Species: Mus musculus
• Alignment Length: 486
• Identity: 110/486 - (22%)
• Similarity: 149/486 - (30%)
• Gaps: 210/486 - (43%)

  Fly    65 TASGIGKPNR-SRFMINDILAGSAAAAFYKQQ---------------------QHHQQLHHHNNN 107
            |..|...|.| |.|:|.::||..|..|....|                     |..::|......
Mouse     6 TEPGRATPARASSFLIENLLAAEAKGAGRSTQGDGVREEEEEDDDDPEDEDPEQARRRLQRRRQQ 70

  Fly   108 NNSGSSGGSSPAHSNNNNNINGDNCEASNVAGVGVLPSALHHPQPHPPTHPHTHPHALMHPHGKL 172
            ......||.:.|.:                .|:|          |.||..|.
Mouse    71 RAGSGPGGEARARA----------------LGLG----------PRPPPGPG------------- 96

  Fly   173 GHFPPTAGGNGLNVAQYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVAAPPVDGGVDGG 237
               ||.|.|.|.....|                                      |.|.||..|
Mouse    97 ---PPFALGCGGTTRWY--------------------------------------PRVHGGYGG- 119

  Fly   238 VGLAPPAGGDLDDSSDYHEENED----------CDSGNMDDHSVCSNG---GKDD-----DGNSV 284
             ||:|    |..| .|..|..|:          |.........|.:.|   |.::     :..:|
Mouse   120 -GLSP----DTSD-RDSPETGEEMGRAESAWPRCPGPGTVPREVTTQGPATGGEEAAELAEAPAV 178

  Fly   285 KSGSTSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQN 349
            .:.:|.:..|  .:::|.||.|:..|:..||.:|:.::|||..||..||..|.|::.|||.|:||
Mouse   179 AAAATGEARG--GRRKKTRTVFSRSQVFQLESTFDLKRYLSSAERAGLAASLQLTETQVKIWFQN 241

  Fly   350 RRTKWKRQTAVGLELLAEAGNFAAFQRLYGGSPYLGAWPYAAAAGAAHGATPHTNIDIYYRQAAA 414
            ||.|||||.|..||                           ||:.:..||.....:.:.|.::..
Mouse   242 RRNKWKRQLAAELE---------------------------AASLSPPGAQRLVRVPVLYHESPP 279

  Fly   415 AAAMQKPLPYNLYAGVPSVGVGVGVGVGPA-PFSHLSASSSLSSLSSYYQSAAAAASAANPGGPH 478
            |||                        ||| ||                           |..|.
Mouse   280 AAA------------------------GPALPF---------------------------PLAPP 293

  Fly   479 PVAPPPSVGGGSPPSGLVKPIPAHSASASPP 509
            ..||||.:.|.|  ..|..|:.|..|:||.|
Mouse   294 APAPPPPLLGFS--GALAYPLAAFPAAASVP 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	27/55 (49%)
Hmx1	NP_034575.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..170		37/228 (16%)
		Homeodomain	192..248	CDD:459649	27/55 (49%)
		HMX family specific domain 1	251..261		5/36 (14%)
		HMX family specific domain 2	264..277		2/12 (17%)