Protein Alignment B-H1 and CDX4

DIOPT Version :10

• Sequence 1: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_005184.1
• Gene: CDX4 / 1046
• HGNCID: 1808
• Length: 284
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 73/321 - (22%)
• Similarity: 108/321 - (33%)
• Gaps: 126/321 - (39%)

  Fly    55 TTMSSGGSTTTASGIGKPNRSRFMINDILAGSAAAAFYKQQQHHQQLHHHNNNNNSGSSGGSSPA 119
            |.||.||..|..:|                                          |:.||.||
Human    17 TLMSPGGDGTAGTG------------------------------------------GTGGGGSP- 38

  Fly   120 HSNNNNNINGDNCEASNVAGVGVLPSALHH-PQPHPPTHPHTHPHALMHPHGKLGHFPPTAGGNG 183
                        ..|||.|..   |:..|: ..||.|:         |.||.      |:.|..|
Human    39 ------------MPASNFAAA---PAFSHYMGYPHMPS---------MDPHW------PSLGVWG 73

  Fly   184 LNVAQYAAAMQQHYA----AAAAAAAARNNAAAAAAAAAAAAAAGVAAPPVDGGVDGGVGLAPPA 244
               :.|:...:....    ::.......|:..::.||..:...:.:.  ||.||..|. .|...|
Human    74 ---SPYSPPREDWSVYPGPSSTMGTVPVNDVTSSPAAFCSTDYSNLG--PVGGGTSGS-SLPGQA 132

  Fly   245 GGDLDDSSDYHEENEDCDSGNMDDHSVCSNGGKDDDGNSVKSGS--------------TSDMSGL 295
            ||.|..:                            |..:.|:.|              |..::|.
Human   133 GGSLVPT----------------------------DAGAAKASSPSRSRHSPYAWMRKTVQVTGK 169

  Fly   296 SKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKR 356
            ::.:.|.|..:||||...|||.|...:|:::|.:.|||..|.||:.|||.|:||||.|.::
Human   170 TRTKEKYRVVYTDHQRLELEKEFHCNRYITIQRKSELAVNLGLSERQVKIWFQNRRAKERK 230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	27/55 (49%)
CDX4	NP_005184.1	Caudal_act	13..170	CDD:461413	46/259 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..40		12/77 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..155		11/63 (17%)
		Homeodomain	175..230	CDD:459649	27/54 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..259