DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment B-H1 and Barhl2

DIOPT Version :9

Sequence 1:	NP_523387.1	Gene:	B-H1 / 32724	FlyBaseID:	FBgn0011758	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001005477.1	Gene:	Barhl2 / 104382	MGIID:	1859314	Length:	384	Species:	Mus musculus

Alignment Length:	425	Identity:	145/425 - (34%)
Similarity:	193/425 - (45%)	Gaps:	103/425 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GSSGGS-------SPAHSNNNNNINGD-----------------NCEASNVAGVGVLPSA----- 146
            |:||.|       |.|.|.:...:|||                 ....|.:..||..||:
Mouse     6 GASGSSFGIDTILSGAGSGSPGMMNGDFRSLGEARTTDFRSQATPSPCSEIDTVGTAPSSPISVT 70

  Fly   147 LHHPQPH-----PPTHPHTHPHALMHPHGKLGHFPPTAGGNGLNVAQYAAAMQQHYAAAAAAAAA 206
            |..|:||     |..|.|.| |:...|       ||:|     ..||......|........:||
Mouse    71 LEPPEPHLVTDGPQHHHHLH-HSQQPP-------PPSA-----VPAQSLQPSPQQQPPPQPQSAA 122

  Fly   207 RNNAAAAAAAAAAAAAAGVA-----APPVDGGVDGGVGLAPPAGGDLDDSSDYHE------ENED 260
            :...:||||...:.::..:.     :.|:.........::.|......:|:..||      |.||
Mouse   123 QQLGSAAAAPRTSTSSFLIKDILGDSKPLAACAPYSTSVSSPHHTPKQESNAAHESFRPKLEQED 187

  Fly   261 ----CDSGNMDDHSVCSNGGKDDDGNSVKSGSTSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQ 321
                .|........:..:|.|::....:.| |.......:||.|||||||:||||..||:|||||
Mouse   188 GKTKLDKREDPQSDIKCHGTKEEGDREITS-SRESPPVRAKKPRKARTAFSDHQLNQLERSFERQ 251

  Fly   322 KYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNFAAFQRLYGGSPY--- 383
            ||||||:|.:||..|:|:|.|||||||||||||||||||||||||||||::|.||:: .|||
Mouse   252 KYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMF-PSPYFYH 315

  Fly   384 ---LGAWPYAAAAGAAHGATPHTNIDIYYRQAAAAAAMQKPLPYNLYAGVPSVGV-GVGVGVGPA 444
               ||:.....||.||  |..:::  :|....|....:|:||       ||.|.: |:|.|..||
Mouse   316 PSLLGSMDSTTAAAAA--AAMYSS--MYRTPPAPHPQLQRPL-------VPRVLIHGLGPGGQPA 369

  Fly   445 PFSHLSASSSLSSLSSYYQSAAAAASAANPGGPHP 479
                      |:.||:           ..||.|||
Mouse   370 ----------LNPLSN-----------PIPGTPHP 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B-H1	NP_523387.1	Homeobox	303..355	CDD:278475	39/51 (76%)
Barhl2	NP_001005477.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		37/140 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..235		18/81 (22%)
		Homeobox	233..285	CDD:278475	39/51 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..384		11/41 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833022
Domainoid	1	1.000	103	1.000	Domainoid score	I6762
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4319
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002353
OrthoInspector	1	1.000	-	-		mtm8702
orthoMCL	1	0.900	-	-		OOG6_109676
Panther	1	1.100	-	-	O	PTHR24330
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10747
SonicParanoid	1	1.000	-	-		X1387
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.780