Protein Alignment B-H2 and Nkx1-1

DIOPT Version :10

• Sequence 1: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_035450.1
• Gene: Nkx1-1 / 672284
• MGIID: 109346
• Length: 440
• Species: Mus musculus
• Alignment Length: 578
• Identity: 128/578 - (22%)
• Similarity: 177/578 - (30%)
• Gaps: 193/578 - (33%)

  Fly     4 MPPEMSATTAAPVGSAPSATAHH--------PAAVGGGMPRPASPAVGSNTTTATATTATRSR-- 58
            :||......:.|...||:|||..        |.....|:|    |...|:|..|....|..:|
Mouse    15 LPPPPPGPGSGPAPPAPAATARDTMDGRAELPIFPRAGVP----PLAASDTVPAVPEGAGAARPA 75

  Fly    59 -------FMITDI--------------LAGAAAASAAAAAAAAALAAASSGGGRGSPTDSEREQS 102
                   |.:.||              |.|....:..|..|.||..|..:..||....:.||...
Mouse    76 APPRPTSFSVLDILDPNKFNSRRRRCVLLGPVVPATCAPCAPAACVAVPAASGRSPRAELERRAL 140

  Fly   103 LVAQHHHHHQQQQQHHHHQQQQQQQQHQQAALQQYIVQQQQLLRFEREREREREREHYRERHSPP 167
            ..|.              ...........:|...|             |..|.|...|   .|..
Mouse   141 SAAT--------------GVAAAAGAEPTSAGDSY-------------RADEAEANGY---SSGS 175

  Fly   168 GNNPYAHHPMPPHLLAHFPPAHYAVLQQQQQQQQQQQHPHPHHLQLERERLEALHRHGHGLTGDP 232
            |.:|.|                          ..:.:.|.      :.:..||
Mouse   176 GRSPTA--------------------------DSEDEAPE------DEDEEEA------------ 196

  Fly   233 AQHLSHLSHLSHQQHHPHLHHPMHDERSRSPLMLQQLGGNGGNNNNNNNNSSSASNNNNNNNNSA 297
                            |.:......|..|        ||:||.....:....:|....:..:::|
Mouse   197 ----------------PEVQDAQGTEEPR--------GGSGGLGARGSGCPGAAEVEASPVDDTA 237

  Fly   298 SANSNIISGNSSSSNNNNGSGNGNMLLGGPGSSISGDQASTIDDSDSDDCGGKDDDGDDSMKNGS 362
            :....   |||..:.....:..|   .|..||:..|...:|...        :...|.|| |:|
Mouse   238 APGPR---GNSPGAPGPPATATG---AGSAGSTPQGAAVTTKPK--------RKRTGSDS-KSG- 286

  Fly   363 SANGDSSSHLSLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRMELANKLELSDCQVKTW 427
                            |.|:||||||..||..||..|:..:||||.:|:.||..|.|::.|||.|
Mouse   287 ----------------KPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIW 335

  Fly   428 YQNRRTKWKRQTAVGLELLAEAGNYAAFQRLYGGATPYLSAWPYAAAAAAQSPHGATPSAIDIYY 492
            :||||||||:|.. |.:..|..|         ||..|...|.|.|......||...:|
Mouse   336 FQNRRTKWKKQNP-GADTSAPTG---------GGGGPGPGAGPGAGLPGGLSPLSPSP------- 383

  Fly   493 RQAAAAAAMQKPSLPASYRMYQSSIPPGM----SLPGMPAPPPPGAAPMLSGYYAAAA 546
             ...|..|:..|:      .|.:..|.|:    .||.:.:|.......:.|..|.|.|
Mouse   384 -PMGAPLALHGPA------GYPAHSPGGLVCAAQLPFLSSPAVLSPFVLGSQTYGAPA 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeodomain	381..437	CDD:459649	32/55 (58%)
Nkx1-1	NP_035450.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		17/70 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..291		38/261 (15%)
		Homeodomain	289..345	CDD:459649	32/55 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..387		16/62 (26%)