DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment B-H2 and Barhl2

DIOPT Version :9

Sequence 1:	NP_523386.1	Gene:	B-H2 / 32723	FlyBaseID:	FBgn0004854	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_075245.1	Gene:	Barhl2 / 65050	RGDID:	620726	Length:	384	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	154/535 - (28%)
Similarity:	191/535 - (35%)	Gaps:	217/535 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ATRSRFMITDILAGAAAAS-------------------AAAAAAAAALAAASSGGGRGSP---TD 96
            |:.|.|.|..||:||.:.|                   .:.|..:......:.|....||   |.
  Rat     7 ASGSSFGIDTILSGAGSGSPGMMNGDFRSLGEARTTDFRSQATPSPCSEIDTVGTAPSSPISVTL 71

  Fly    97 SEREQSLVA---QHHHHHQQQQQHHHHQQQQQQQQHQQAALQQYIVQQQQLLRFERERERERERE 158
            ...|..||.   ||||       |.||.||
  Rat    72 EPPEPHLVTDGPQHHH-------HLHHGQQ----------------------------------- 94

  Fly   159 HYRERHSPPGNNPYAHHPMPPHLLAHFPPAHYAVLQQQQQQQQQQQHPHPHHLQLERERLEALHR 223
                             |.||..    |||     |..|...|||..|.|.....:.....|..|
  Rat    95 -----------------PPPPSA----PPA-----QSLQPSPQQQPPPQPQSAAQQLGSAAAAPR 133

  Fly   224 HG------HGLTGDPAQHLSHLSHLSHQQHHPHLHHPMHD----ERSRSPLMLQQLGGNGGNNNN 278
            ..      ..:.|| ::.|:..:..|.....|| |.|..:    ..|..|.:.|:
  Rat   134 TSTSSFLIKDILGD-SKPLAACAPYSTSVSSPH-HTPKQECNAAHESFRPKLEQE---------- 186

  Fly   279 NNNNSSSASNNNNNNNNSASANSNIISGNSSSSNNNNGSGNGNMLLGGPGSSISGDQASTID--- 340
                                                                   |..:.:|
  Rat   187 -------------------------------------------------------DSKTKLDKRE 196

  Fly   341 DSDSD-DCGGKDDDGDDSMKNGSSANGDSSSHLSLSL-SKKQRKARTAFTDHQLQTLEKSFERQK 403
            ||.|| .|.|..::||..:         :||..|..: :||.|||||||:||||..||:||||||
  Rat   197 DSQSDIKCHGTKEEGDREI---------TSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQK 252

  Fly   404 YLSVQDRMELANKLELSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNYAAFQRLYGGATPYL-- 466
            ||||||||:||..|.|:|.||||||||||||||||||||||||||||||:|.||::  .:||.
  Rat   253 YLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMF--PSPYFYH 315

  Fly   467 --------SAWPYAAAAAAQSPHGATPSAIDIYYRQAAAAAAMQKPSLPASYRMYQSSIPPG--- 520
                    |....|||||..|....||         .|....:|:|.:|   |:....:.||
  Rat   316 PSLLGSMDSTTAAAAAAAMYSSMYRTP---------PAPHPQLQRPLVP---RVLIHGLGPGGQP 368

  Fly   521 ------MSLPGMPAP 529
                  ..:||.|.|
  Rat   369 ALNPLSNPIPGTPHP 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeobox	384..436	CDD:278475	41/51 (80%)
Barhl2	NP_075245.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		40/194 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..237		29/157 (18%)
		Homeobox	233..285	CDD:278475	41/51 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..384		6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336599
Domainoid	1	1.000	103	1.000	Domainoid score	I6617
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002353
OrthoInspector	1	1.000	-	-		mtm8938
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24330
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1387
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.890