Protein Alignment B-H2 and NKX1-1

DIOPT Version :9

• Sequence 1: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_001277008.1
• Gene: NKX1-1 / 54729
• HGNCID: 24975
• Length: 448
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 129/568 - (22%)
• Similarity: 183/568 - (32%)
• Gaps: 181/568 - (31%)

  Fly     8 MSATTAAPVGSAPSATAHHPAAVGGGMPRPASPAVGSNTTTATATTATRSRFMITDILAGAAAAS 72
            |||:.....|..|:...  |...|.| |.|.:||       |.|..|...|..    |.....|.
Human     1 MSASGPEAPGDIPALPP--PPQPGSG-PAPPAPA-------AAAQEAMDGRAE----LPAFPRAG 51

  Fly    73 AAAAAAAAALAAASSGGGRGSPTDSEREQSLVAQHHHHHQQQQQHHHHQQQQQQQQHQQAALQQY 137
            |...||:..:.||..|.|...|.                                    |.|:..
Human    52 APPLAASDTVPAAPEGAGAARPA------------------------------------APLRPT 80

  Fly   138 IVQQQQLLRFEREREREREREHYRERH-------SPPGNNPYAHHPMPPHLLAHFPPAHYAVLQQ 195
            ......:|        :..:.:.|.|.       :|....|.|..|..|...|...|
Human    81 SFSVLDIL--------DPNKFNSRRRRCVLLGPVAPAACAPCASAPCAPAPAASGRP-------- 129

  Fly   196 QQQQQQQQQHPHPHHLQLERERLEALHRHGHGLTG-DPAQHLSHLSHLSHQQHHPHLHHPMHDER 259
                        |...:|||..|..  ..|.|..| :|                |:...|.....
Human   130 ------------PRAEELERRALAG--AGGVGAAGAEP----------------PNAGDPFKAGE 164

  Fly   260 SRSPLMLQQLGGNGGNNNNNNNNSSSASNNNNNNNNSASANSNIISGNSSSSNNNNGSGNGNMLL 324
            :.:........|.||::.:.::......:.:::.:.:....:      :..:....|.|.|   |
Human   165 AETNDTNGYSSGGGGHSPSADSGDEVPDDEDDDEDEAPETEA------ARGAEEARGGGGG---L 220

  Fly   325 GGPGSSISG------DQASTIDDSDSDDCGGKDDD-------GDDSMKNGSSANGDSSSHL---- 372
            |..||...|      ...:|:|::.:.  |.:::.       |..:...|:......::..
Human   221 GARGSGCQGAAETDASPGATVDEAAAP--GPRENSPVAQGPPGGAAAPGGAGTTPQGTATAAKPK 283

  Fly   373 -----SLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRMELANKLELSDCQVKTWYQNRR 432
                 |.|.|.|.|:||||||..||..||..|:..:||||.:|:.||..|.|::.|||.|:||||
Human   284 RKRTGSDSKSGKPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRR 348

  Fly   433 TKWKRQTAVGLELLAEAGNYAAFQRLYGGATPYLSAWPYAAAAAAQSPHGATPSAIDIYYRQAAA 497
            ||||:|.. |.:..|..|         ||..|...|.|     ....|.|.:|.:
Human   349 TKWKKQNP-GADTSAPTG---------GGGGPGPGAGP-----GTGLPGGLSPLS---------- 388

  Fly   498 AAAMQKPSLPASYRMYQSSIPPGMSLP-GMPAPPPPGAA-----PMLS 539
                  ||.|       ...|.||..| |.||..|.|..     |.||
Human   389 ------PSPP-------MGAPLGMHGPAGYPAHGPGGLVCAAQLPFLS 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeobox	384..436	CDD:278475	29/51 (57%)
NKX1-1	NP_001277008.1	Homeobox	300..352	CDD:278475	29/51 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810