DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B-H2 and NPM1

DIOPT Version :9

Sequence 1:	NP_523386.1	Gene:	B-H2 / 32723	FlyBaseID:	FBgn0004854	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001341935.1	Gene:	NPM1 / 4869	HGNCID:	7910	Length:	294	Species:	Homo sapiens

Alignment Length:	158	Identity:	37/158 - (23%)
Similarity:	60/158 - (37%)	Gaps:	50/158 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 AAAMQKPSLP-----ASYRMYQSSIPPGMSLPGMPAPPPP------GAAPM-LSGYYAAAAAAAA 550
            |.||.....|     |:.:|   |:.|.:||.|....||.      |:.|: :||.:..|....|
Human    62 AEAMNYEGSPIKVTLATLKM---SVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDA 123

  Fly   551 SAGAQQQQQQPPAASRSPATSQSANSEADCERTSSSSRQRLITPSPPLNPGS----PPHRERINE 611
            .:..::                    |.|.:..|.|.::..        ||.    |..:.::..
Human   124 ESEDEE--------------------EEDVKLLSISGKRSA--------PGGGSKVPQKKVKLAA 160

  Fly   612 EEDRERDEERDIERERERERERDEDDEE 639
            :||.:.|:|.|   :.|.:.:.|.||||
Human   161 DEDDDDDDEED---DDEDDDDDDFDDEE 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeobox	384..436	CDD:278475
NPM1	NP_001341935.1	Required for interaction with SENP3	1..186		37/158 (23%)
		Necessary for interaction with APEX1. /evidence=ECO:0000269\|PubMed:19188445	1..117		17/57 (30%)
		Nucleoplasmin	18..117	CDD:397268	17/57 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..247		19/97 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		1/4 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	191..197
		Required for nucleolar localization	243..294
		NPM1-C	245..291	CDD:406641
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900