Protein Alignment B-H2 and Hmx

DIOPT Version :10

• Sequence 1: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Alignment Length: 844
• Identity: 181/844 - (21%)
• Similarity: 254/844 - (30%)
• Gaps: 397/844 - (47%)

  Fly     8 MSATTAAPVGSAPSAT---AHHPAAVGGGMPRPASPAVGSNTTTATATTATRSRFMITDILAGAA 69
            :|:...:|:|:|...:   |..||....|...||:|...|||....|.|.|.|
  Fly    13 VSSPEPSPLGAAARDSPLLARSPARSADGSSPPATPTHRSNTPNTAAGTPTTS------------ 65

  Fly    70 AASAAAAAAAAALAAASSGGGRGSPTDSEREQSLVAQHHHHHQQQ-------QQHHHHQQQQQQQ 127
                            :|||                 :|.||...       ..|||       .
  Fly    66 ----------------ASGG-----------------NHFHHSPSGGAVPPAVLHHH-------L 90

  Fly   128 QHQQAALQQYIVQQQQLLRFEREREREREREHYRERHSPPGNNPYA-HHPMPPHLLAHFPPAHYA 191
            ||..::|                                 |::|.| ||.:  |...|..|||.|
  Fly    91 QHHLSSL---------------------------------GSHPVALHHAL--HTFGHLHPAHGA 120

  Fly   192 V-------------LQQQQQQQQQQQHPHPHHLQLER--------ERLEALHRHGHGLTGDPAQH 235
            .             .|||||.|.||||...|   :||        ||.......||.|..:.::.
  Fly   121 THPALLQHALTPTGQQQQQQLQVQQQHQQSH---VERLSPPMKSPERNGGDEVQGHSLNNNNSKA 182

  Fly   236 LSH--------------------LSHLSHQQHH-------------------------------- 248
            |:|                    ||:.|:..:.
  Fly   183 LNHNNTCASAAAAAAAAAVAAANLSNNSNDSNGSSGGGGGKSTTGSNGFTSFSISSILSRSEPAK 247

  Fly   249 -----------PHL-----------------------------------------------HHPM 255
                       |.|                                               |.|.
  Fly   248 KNGAAGLITPIPQLPQPGAGGPQDAAMLSRLGFISQWGALAGRYAALCPPGWPWAPQRLPFHSPT 312

  Fly   256 HDERSRSPLMLQQLGGNGGNNNNNNNNSSSASNNNNNNNNSASANSNIISGNSS----------- 309
            ||..|.             |...|..:.:|.|.||||||::.:|:||..|.:.|
  Fly   313 HDSSST-------------NTTENPPSPTSMSPNNNNNNSNTTASSNQASKSPSHHPLHPLYHPL 364

  Fly   310 ----------------------------------SSNNNNGSGNGNMLLGGPGSSISGDQASTI- 339
                                              :..:::.||.|:.|...|...::|.....:
  Fly   365 GSQQQQQQQQQHQQHPQQQQHPQQQQQQHPHQPTTPTSSSSSGGGSSLTHHPHPHLTGSHGGYLL 429

  Fly   340 --DDSDSDDCGG---KDDDGDDSMKNGSSANGDSSSHLSLSLSKKQRKARTAFTDHQLQTLEKSF 399
              ..::||:.|.   ::|||.|...:.||.:||.:       ||:::|.||.|:..|:..||.:|
  Fly   430 PSSSNESDEEGEEIIEEDDGTDGPSDSSSPHGDGN-------SKRKKKTRTVFSRAQVFQLESTF 487

  Fly   400 ERQKYLSVQDRMELANKLELSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNYAAFQRLYGGATP 464
            :.::|||..:|..||..|.|::.|||.|:||||.|||||.|..||....|....|.|||.
  Fly   488 DLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQLAAELEAANMANMAHAAQRLV----- 547

  Fly   465 YLSAWPYAAAAAAQSPHGATPSAIDIYYRQAAAAAAMQKPSLPASYRMYQSSIPPGMSLPGMPAP 529
                                  .:.:.|.....|                          |...|
  Fly   548 ----------------------RVPVLYHDGTTA--------------------------GFVPP 564

  Fly   530 PPPGAAPMLSGYYAAAAAAAASAGAQQQQQQPPAASRSPATSQSANSEADCERTSSSSRQRLITP 594
            |||...||  .|||||           :...||   |.|.:|.. .  ..|..|:..|..:
  Fly   565 PPPHHHPM--QYYAAA-----------RNTSPP---RPPLSSLVXG--VGCLATAPMSLLK---- 607

  Fly   595 SPPLNPGSPPH-------------RERINEEEDRERDEERDIERERERERERDEDDEEELALEV 645
             ||.:...|||             |..:..|:..|.|.:.|.|:||....     |:|:.|::|
  Fly   608 -PPNSMAHPPHPQPPPPAPLHMQQRSFLGCEQLTETDMDSDSEQERSHMM-----DDEDAAIDV 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeodomain	381..437	CDD:459649	26/55 (47%)
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	26/55 (47%)