Protein Alignment B-H2 and NKX1-2

DIOPT Version :10

• Sequence 1: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_001139812.1
• Gene: NKX1-2 / 390010
• HGNCID: 31652
• Length: 310
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 75/264 - (28%)
• Similarity: 109/264 - (41%)
• Gaps: 77/264 - (29%)

  Fly   326 GPGSSISGDQASTIDDSDSDDCGGKDDDGDDSMK---------------------NGSSANGDSS 369
            |||:.    |||.::.|::::    ::|.:|..:                     .|:.|:|:..
Human    75 GPGAG----QASPLEGSEAEE----EEDAEDPRRPRLRERAARLLPGLARSPDAPAGALASGEPC 131

  Fly   370 S----------------------HLSLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRME 412
            .                      .|..:.: |.|:||||||..||..||..|...:||||.:|:.
Human   132 EDGGGGPVRSPPGSPGSPRPRRRRLEPNCA-KPRRARTAFTYEQLVALENKFRATRYLSVCERLN 195

  Fly   413 LANKLELSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNYAAFQRLYGGATPYLSAWPYAAAAAA 477
            ||..|.|::.|||.|:||||||||:|.. |.:..|:.|         |||..     |.||....
Human   196 LALSLSLTETQVKIWFQNRRTKWKKQNP-GADGAAQVG---------GGAPQ-----PGAAGGGG 245

  Fly   478 QSPHGATPSAIDIYYRQAAAAAAMQK-PSLPASYRMYQS--SIPPGMSLPGMPAPPPPGAAPMLS 539
            ....|.:|..      ....|...|. ||..|:..::.|  |.|...:.||.|..|..|.: .|:
Human   246 GGGSGGSPGP------PGTGALHFQTFPSYSAANVLFPSAASFPLTAAAPGSPFAPFLGPS-YLT 303

  Fly   540 GYYA 543
            .:||
Human   304 PFYA 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeodomain	381..437	CDD:459649	32/55 (58%)
NKX1-2	NP_001139812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..165		14/98 (14%)
		Homeodomain	164..220	CDD:459649	32/55 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..260		15/63 (24%)