Protein Alignment B-H2 and HOXD13

DIOPT Version :10

• Sequence 1: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_000514.2
• Gene: HOXD13 / 3239
• HGNCID: 5136
• Length: 343
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 98/433 - (22%)
• Similarity: 146/433 - (33%)
• Gaps: 137/433 - (31%)

  Fly    29 AVGGGMPRPASPAVGSNTTTATATTATRSR-FMITDILAGAAAASAAAAAAAAALAAASSGGGRG 92
            |.|||  ...:||..|:::.|.|..:.:.| |:...:.||..:..||||||||| |||::..|..
Human    14 ADGGG--AGGAPASSSSSSVAAAAASGQCRGFLSAPVFAGTHSGRAAAAAAAAA-AAAAAASGFA 75

  Fly    93 SPTDSEREQSLVAQHHHHHQQQQQHHHHQQQQQQQQHQQAALQQYIVQQQQLLRFERERERERER 157
            .|..|||..|                           ..::....:|    ..|.|....:|
Human    76 YPGTSERTGS---------------------------SSSSSSSAVV----AARPEAPPAKE--- 106

  Fly   158 EHYRERHSPPGNNPYAHHPMPPHLLA-----HFPPAHYAVLQQQ---QQQQQQQQHPHPHHLQLE 214
                    .|...|.|....||...|     ||...:|:.....   .||...:..||.
Human   107 --------CPAPTPAAAAAAPPSAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHA------ 157

  Fly   215 RERLEALHRHGHGLTGDPAQHLSHLSHLSHQQHHPHLHHPMHDERSRSPLMLQQLGGNGGNNNNN 279
                        .|.|.|.:....:|.|:
Human   158 ------------SLGGFPVEKYMDVSGLA------------------------------------ 174

  Fly   280 NNNSSSASNNNNNNNNSASANSNIIS---GNSSSSNNNNG-----SGNGNMLLGGPGS----SIS 332
               |||..      .|...|.:..:|   |.:|...:..|     |..|:   |.|..    |:.
Human   175 ---SSSVP------ANEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGS---GEPRHEAYISME 227

  Fly   333 GDQASTIDDSDSDD--CGGKDDDGDDSMKNGSSANGD-SSSHLSLSLSKKQRKARTAFTDHQLQT 394
            |.|:.|:.:..:..  |......|....|  ||..|| :.:...:.:.::.||.|..:|..||:.
Human   228 GYQSWTLANGWNSQVYCTKDQPQGSHFWK--SSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKE 290

  Fly   395 LEKSFERQKYLSVQDRMELANKLELSDCQVKTWYQNRRTKWKR 437
            ||..:...|:::...|..::....||:.||..|:||||.|.|:
Human   291 LENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKK 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeodomain	381..437	CDD:459649	20/55 (36%)
HOXD13	NP_000514.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		6/15 (40%)
		polyalanine repeat	57..71		12/14 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..115		10/78 (13%)
		HoxA13_N	<100..172	CDD:463521	18/100 (18%)
		Homeodomain	277..333	CDD:459649	20/55 (36%)