Protein Alignment B-H2 and HOXA1

DIOPT Version :10

• Sequence 1: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_005513.2
• Gene: HOXA1 / 3198
• HGNCID: 5099
• Length: 335
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 97/441 - (21%)
• Similarity: 135/441 - (30%)
• Gaps: 184/441 - (41%)

  Fly    54 ATRSRFMITDILAGAAAASAAAAA----------AAAALAAASSGG------GRGSPTDSEREQS 102
            |..:.|:...||:...:.:.:|.|          .:.|::|.|.||      |||..
Human     4 ARMNSFLEYPILSSGDSGTCSARAYPSDHRITTFQSCAVSANSCGGDDRFLVGRGVQ-------- 60

  Fly   103 LVAQHHHHHQQQQQHHHHQQQQQQQQHQQAALQQYIVQQQQLLRFEREREREREREHYRERHSPP 167
             :...||||     ||||       :|.|.|..|                             ..
Human    61 -IGSPHHHH-----HHHH-------RHPQPATYQ-----------------------------TS 83

  Fly   168 GN--NPYAHHPMPP-----HLLAHFPPAHYAVLQQQQQQQQQQQ-HPHPHHLQLERERLEALHRH 224
            ||  ..|:|....|     :..|.:.|  ||:.|:........| .|..:...|....::  |.|
Human    84 GNLGVSYSHSSCGPSYGSQNFSAPYSP--YALNQEADVSGGYPQCAPAVYSGNLSSPMVQ--HHH 144

  Fly   225 GH-----GLTGDPAQHLSHLSHLSHQQHHPHLH-----------HPMHDERSRSPLMLQQLGGNG 273
            .|     |..|.| |::.|    |:.|.|..|.           |..|.|..|||
Human   145 HHQGYAGGAVGSP-QYIHH----SYGQEHQSLALATYNNSLSPLHASHQEACRSP---------- 194

  Fly   274 GNNNNNNNNSSSASNNNNNNNNSASANSNIISGNSSSSNNNNGSGNGNMLLGGPGSSISGDQAST 338
                                                                   :|.:...|.|
Human   195 -------------------------------------------------------ASETSSPAQT 204

  Fly   339 IDDSDSDDCGGKDDDGDDSMKNGSSANGDSSSHLSLSLSKKQRKARTAFTDHQLQTLEKSFERQK 403
            .|..              .:|......|....:..|.   :....||.||..||..|||.|...|
Human   205 FDWM--------------KVKRNPPKTGKVGEYGYLG---QPNAVRTNFTTKQLTELEKEFHFNK 252

  Fly   404 YLSVQDRMELANKLELSDCQVKTWYQNRRTKWKRQTAVGLELLAEA---GN 451
            ||:...|:|:|..|:|::.|||.|:||||.|.|::...||..::.|   ||
Human   253 YLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGN 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeodomain	381..437	CDD:459649	27/55 (49%)
HOXA1	NP_005513.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..80		11/30 (37%)
		Interaction with OGT. /evidence=ECO:0000250|UniProtKB:P09022	75..203		35/230 (15%)
		COG5576	176..>286	CDD:227863	40/191 (21%)
		Antp-type hexapeptide	204..209		2/18 (11%)
		Homeodomain	233..286	CDD:459649	27/52 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..335		8/23 (35%)