DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment B-H2 and Arx

DIOPT Version :9

Sequence 1:	NP_523386.1	Gene:	B-H2 / 32723	FlyBaseID:	FBgn0004854	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001093644.1	Gene:	Arx / 317268	RGDID:	1562672	Length:	566	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	163/645 - (25%)
Similarity:	232/645 - (35%)	Gaps:	208/645 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TMPPEMSATT-------AAPVG-SAP-SATAHHPAAV------GGGMPRPASPAVGSNTTTATAT 52
            ::|..:::.|       .:|.| ||| .|..|.|..:      |||.
  Rat    49 SLPAPLASRTDQEKAMQGSPKGSSAPFEAELHLPPKLRRLYGPGGGR------------------ 95

  Fly    53 TATRSRFMITDILAGAAAASAAAAAAAAALAAAS-SGGGRG--------SPTDSEREQSLVAQHH 108
                       :|.|||||:|||||||||.|.|: :.|.||        :....||:.|..|
  Rat    96 -----------LLQGAAAAAAAAAAAAAAAATATGTAGPRGEVPPPPPPAARPGERQDSAGA--- 146

  Fly   109 HHHQQQQQHHHHQQQQQQQQHQQAALQQYIVQQQQLLRFEREREREREREHYRERHSPPGNNPYA 173
                             ......||.....:.|...:...|.:.       |||..:|
  Rat   147 -----------------VAAAAAAAWDTLKISQAPQVSISRSKS-------YRENGAP------- 180

  Fly   174 HHPMPPHLLAHFPPAHYAVLQQQQQQQQQQQHPHPHHLQLERERLEALHRHGH-----GLTGDPA 233
            ..|.||.|.....|...|               ||      .|||.|....|.     |.||.
  Rat   181 FVPPPPALDELGGPGGVA---------------HP------EERLSAASGPGSAPAAGGGTGT-- 222

  Fly   234 QHLSHLSHLSHQQHHPHLHHPMHDERSRSPLMLQQLGGNGGNNNNNNNNSSSASNNNNNNNNSAS 298
                       ::....|.....||.....|:         .::........|..........:.
  Rat   223 -----------EEDEEELLEDEEDEDEEEELL---------EDDEEELLEDDARALLKEPRRCSV 267

  Fly   299 ANSNIISGNSSSSNNNNGSGNGNMLLGGPGSSISGDQASTIDDSDSDDCGGKDDDGDDSMKNGSS 363
            |.:..::..::::       .....:...|..:|..:...:...|::   ||  ||:||:  ..|
  Rat   268 ATTGTVAAAAAAA-------AAAAAVATEGGELSPKEELLLHPEDAE---GK--DGEDSV--CLS 318

  Fly   364 ANGDSSSHLSLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRMELANKLELSDCQVKTWY 428
            |..||...|   |.:|||:.||.||.:||:.||::|::..|..|..|.|||.:|:|::.:|:.|:
  Rat   319 AGSDSEEGL---LKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWF 380

  Fly   429 QNRRTKWKRQTAVGLEL----LAEAGNYAAFQRLYGGATPYLSAWPYAAAAAAQSPHGATPSAID 489
            ||||.||:::...|.:.    |...|..:|...|    :|||.|.|:       .||   ..|:|
  Rat   381 QNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPL----SPYLDASPF-------PPH---HPALD 431

  Fly   490 IYYRQAAAAAAMQKPSLPASYRMYQSSIPPGMSLPGMPAPPPPGAAPMLSGYYAAAA-------- 546
            ..:..||||||...||||          ||    ||..:.||.||...||.:..||.
  Rat   432 SAWTAAAAAAAAAFPSLP----------PP----PGSASLPPSGAPLGLSTFLGAAVFRHPAFIS 482

  Fly   547 ------------AAAASAGAQQQQQQPPA---ASRSPATSQSANSEADCERTSSSSRQRL 591
                        ..:||..|...:|..||   |..|.|.:..|.:.|| .|.||.:..||
  Rat   483 PAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAAD-RRASSIAALRL 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeobox	384..436	CDD:278475	24/51 (47%)
Arx	NP_001093644.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..79		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..264		36/221 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..319		9/39 (23%)
		Homeobox	336..388	CDD:278475	24/51 (47%)
		OAR	530..547	CDD:281777	6/13 (46%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	534..547		4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4496
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050