Protein Alignment B-H2 and Nkx1-1

DIOPT Version :10

• Sequence 1: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_234082.6
• Gene: Nkx1-1 / 298981
• RGDID: 1564874
• Length: 443
• Species: Rattus norvegicus
• Alignment Length: 575
• Identity: 129/575 - (22%)
• Similarity: 182/575 - (31%)
• Gaps: 191/575 - (33%)

  Fly     5 PPEMSATTAAPVGSAPSATAHHPAAVGGGMPRPASPAVG------SNTTTATATTATRSR----- 58
            |||..:..|.|   ||:|||..  |:.|....|..|..|      |:|..|....|..:|
  Rat    21 PPEPGSGPAPP---APAATARD--AMDGRAELPIFPRAGVPPLAVSDTVPAVPDGAGAARPAAPP 80

  Fly    59 ----FMITDI--------------LAGAAAASAAAAAAAAALAAASSGGGRGSPTDSEREQSLVA 105
                |.:.||              |.|....:..|..|.||.....:..||....:.|| ::|.|
  Rat    81 RPTSFSVLDILDPNKFNSRRRRCVLLGPVVPATCAPCAPAACVPVPAASGRSPRAELER-RALSA 144

  Fly   106 QHHHHHQQQQQHHHHQQQQQQQQHQQAALQQYIVQQQQLLRFEREREREREREHYRERHSPPGNN 170
                                      |.........:.....:..|..|.|...|   .|..|.:
  Rat   145 --------------------------ATGVAAATGAEPTSTGDSYRADEAEANGY---SSGSGRS 180

  Fly   171 PYAHHPMPPHLLAHFPPAHYAVLQQQQQQQQQQQHPHPHHLQLERERLEALHRHGHGLTGDPAQH 235
            |.|.                :..:..::.:.:.|.|....:|              | |.:|.
  Rat   181 PTAD----------------SEDEAPEEDEDEDQAPEVQDVQ--------------G-TEEPR-- 212

  Fly   236 LSHLSHLSHQQHHPHLHHPMHDERSRSPLMLQQLGGNGGNNNNNNNNSSSASNNNNNNNNSASAN 300
                                              ||:||.....:..|.:|....:..:.:|:..
  Rat   213 ----------------------------------GGSGGLGARGSGCSGAAEVEASPVDEAAAPG 243

  Fly   301 SNIISGNSSSSNNNNGSGNGNMLLGGPGSSISGDQASTIDDSDSDDCGGKDDDGDDSMKNGSSAN 365
            ..   |||.      |:....:...|.|::.|..|.:.:.........|.|
  Rat   244 PR---GNSP------GAPGPPVTAAGAGNAGSTPQGAAVATKPKRKRTGSD-------------- 285

  Fly   366 GDSSSHLSLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRMELANKLELSDCQVKTWYQN 430
                     |.|.|.|:||||||..||..||..|:..:||||.:|:.||..|.|::.|||.|:||
  Rat   286 ---------SKSGKPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQN 341

  Fly   431 RRTKWKRQTAVGLELLAEAGNYAAFQRLYGGATPYLSAWPYAAAAAAQSPHGATPSAIDIYYRQA 495
            ||||||:|.. |.:..|..|         ||..|...|.|.|......||...:|        ..
  Rat   342 RRTKWKKQNP-GADTSAPTG---------GGGGPGPGAGPGAGLPGGLSPLSPSP--------PM 388

  Fly   496 AAAAAMQKPSLPASYRMYQSSIPPGM----SLPGMPAPPPPGAAPMLSGYYAAAA 546
            .|..|:..|:      .|.:..|.|:    .||.:.:|.......:.|..|.|.|
  Rat   389 GAPLALHGPA------GYPAHSPGGLVCAAQLPFLSSPAVLSPFVLGSQTYGAPA 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeodomain	381..437	CDD:459649	32/55 (58%)
Nkx1-1	XP_234082.6	Homeodomain	292..348	CDD:459649	32/55 (58%)