DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B-H2 and Npm1

DIOPT Version :9

Sequence 1:	NP_523386.1	Gene:	B-H2 / 32723	FlyBaseID:	FBgn0004854	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_037124.1	Gene:	Npm1 / 25498	RGDID:	3192	Length:	292	Species:	Rattus norvegicus

Alignment Length:	155	Identity:	36/155 - (23%)
Similarity:	63/155 - (40%)	Gaps:	41/155 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 AAAMQKPSLP-----ASYRMYQSSIPPGMSLPGMPAPPPP------GAAPM-LSGYYAAAAAAAA 550
            |.||.....|     |:.:|   |:.|.:||.|....||.      |:.|: :||.:..|.
  Rat    62 AEAMNYEGSPIKVTLATLKM---SVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAV---- 119

  Fly   551 SAGAQQQQQQPPAASRSPATSQSANSEADCERTSSSSRQRLITPSPPLNPGSPPHRERINEEEDR 615
                           ...|.|:..:.| |.:....|.::     |.| ..|:...::::..:||.
  Rat   120 ---------------EEDAESEDEDEE-DVKLLGMSGKR-----SAP-GGGNKVPQKKVKLDEDD 162

  Fly   616 ERDEERDIERERERERERDEDDEEE 640
            :.|:|.|.:.|.:.:.:.||::.||
  Rat   163 DEDDEDDEDDEDDDDDDFDEEETEE 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeobox	384..436	CDD:278475
Npm1	NP_037124.1	Required for interaction with SENP3. /evidence=ECO:0000250	1..185		34/151 (23%)
		Necessary for interaction with APEX1. /evidence=ECO:0000250	1..117		17/57 (30%)
		Nucleoplasmin	18..117	CDD:397268	17/57 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..248		14/56 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		0/4 (0%)
		Nuclear localization signal. /evidence=ECO:0000255	190..196
		Required for nucleolar localization. /evidence=ECO:0000250	241..292
		NPM1-C	243..289	CDD:406641
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900