Protein Alignment B-H2 and NKX2-6

DIOPT Version :10

• Sequence 1: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 79/273 - (28%)
• Similarity: 109/273 - (39%)
• Gaps: 64/273 - (23%)

  Fly   310 SSNNNNGSGNGNMLLGGPGSSISGDQASTIDDSDSDDCG---------------------GKDDD 353
            |..:|.|.|.|:..|  .||...|.....:.:.|::..|                     |..:.
Human    53 SEVHNAGGGGGDRKL--DGSEPPGGPCEAVLEMDAERMGEPQPGLNAASPLGGGTRVPERGVGNS 115

  Fly   354 GDDSMKNGSSANGDSSSHLSLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRMELANKLE 418
            | ||::.|.|..         ..::::||.|..|:..|:..||:.|::|:|||..:|..||:.|:
Human   116 G-DSVRGGRSEQ---------PKARQRRKPRVLFSQAQVLALERRFKQQRYLSAPEREHLASALQ 170

  Fly   419 LSDCQVKTWYQNRRTKWKRQTA-VGLELLAEAGNYAAFQRLYGGATPYL------SAWPYAAAAA 476
            |:..|||.|:||||.|.|||.. ..|||   ||:....:|:   |.|.|      ...|...|.|
Human   171 LTSTQVKIWFQNRRYKCKRQRQDKSLEL---AGHPLTPRRV---AVPVLVRDGKPCLGPGPGAPA 229

  Fly   477 AQSPHGATPSAIDIY-----------YRQAAAAAAMQKPSLPASYRMYQSSIPPGMSLPGMPAPP 530
            ..||:.|..|....|           |....|.|    ||.||.:....|:   |....|..|.|
Human   230 FPSPYSAAVSPYSCYGGYSGAPYGAGYGTCYAGA----PSGPAPHTPLASA---GFGHGGQNATP 287

  Fly   531 PPGAAPMLSGYYA 543
            ....|..|.|..|
Human   288 QGHLAATLQGVRA 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeodomain	381..437	CDD:459649	26/55 (47%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		18/93 (19%)
		Homeodomain	133..189	CDD:459649	26/55 (47%)