Protein Alignment B-H2 and Arx

DIOPT Version :9

• Sequence 1: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_001292869.1
• Gene: Arx / 11878
• MGIID: 1097716
• Length: 564
• Species: Mus musculus
• Alignment Length: 568
• Identity: 149/568 - (26%)
• Similarity: 210/568 - (36%)
• Gaps: 164/568 - (28%)

  Fly    64 ILAGAAAASAAAAAAAAALAAASSGGGRG--------SPTDSEREQSLVAQHHHHHQQQQQHHHH 120
            :|.|||||:|||||||||..|..:.|.||        :....||:.|..|
Mouse    96 LLQGAAAAAAAAAAAAAAATATGTAGPRGEVPPPPPPAARPGERQDSAGA--------------- 145

  Fly   121 QQQQQQQQHQQAALQQYIVQQQQLLRFEREREREREREHYRERHSPPGNNPYAHHPMPPHLLAHF 185
                .......||.....:.|...:...|.:.       |||..:|       ..|.||.|....
Mouse   146 ----VAAAAAAAAWDTLKISQAPQVSISRSKS-------YRENGAP-------FVPPPPALDELS 192

  Fly   186 PPAHYAVLQQQQQQQQQQQHPHPHHLQLERERLEALHRHGH-----GLTGDPAQHLSHLSHLSHQ 245
            .|...|               ||      .|||.|....|.     |.||             .:
Mouse   193 GPGGVA---------------HP------EERLSAASGPGSAPAAGGGTG-------------AE 223

  Fly   246 QHHPHLHHPMHDERSRSPLMLQQLGGNGGNNNNNNNNSSSASNNNNNNNNSASANSNIISGNSSS 310
            .....|.....||.....|:         .:::.......|..........:.|.:..::..:::
Mouse   224 DDEEELLEDEEDEEEEEELL---------EDDDEELLEDDARALLKEPRRCSVATTGTVAAAAAA 279

  Fly   311 SNNNNGSGNGNMLLGGPGSSISGDQASTIDDSDSDDCGGKDDDGDDSMKNGSSANGDSSSHLSLS 375
            :         ...:...|..:|..:...:...|::   ||  ||:||:  ..||..||...|
Mouse   280 A---------AAAVATEGGELSPKEELLLHPEDAE---GK--DGEDSV--CLSAGSDSEEGL--- 325

  Fly   376 LSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRMELANKLELSDCQVKTWYQNRRTKWKRQTA 440
            |.:|||:.||.||.:||:.||::|::..|..|..|.|||.:|:|::.:|:.|:||||.||:::..
Mouse   326 LKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 390

  Fly   441 VGLEL----LAEAGNYAAFQRLYGGATPYLSAWPYAAAAAAQSPHGATPSAIDIYYRQAAAAAAM 501
            .|.:.    |...|..:|...|    :|||.|.|:       .||   ..|:|..:..||||||.
Mouse   391 AGAQTHPPGLPFPGPLSATHPL----SPYLDASPF-------PPH---HPALDSAWTAAAAAAAA 441

  Fly   502 QKPSLPASYRMYQSSIPPGMSLPGMPAPPPPGAAPMLSGYYAAAA-------------------- 546
            ..||||          ||    ||..:.||.||...||.:..||.
Mouse   442 AFPSLP----------PP----PGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAP 492

  Fly   547 AAAASAGAQQQQQQPPA---ASRSPATSQSANSEADCERTSSSSRQRL 591
            ..:||..|...:|..||   |..|.|.:..|.:.|| .|.||.:..||
Mouse   493 LTSASTAAALLRQPTPAVEGAVASGALADPATAAAD-RRASSIAALRL 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeobox	384..436	CDD:278475	24/51 (47%)
Arx	NP_001292869.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	54..79
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..264		40/228 (18%)
		Homeobox	334..386	CDD:278475	24/51 (47%)
		OAR	528..545	CDD:281777	6/13 (46%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	532..545		4/8 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	135	1.000	Inparanoid score	I4548
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050