Protein Alignment B-H2 and nkx1-1

DIOPT Version :10

• Sequence 1: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_002936812.1
• Gene: nkx1-1 / 100493120
• XenbaseID: XB-GENE-488879
• Length: 408
• Species: Xenopus tropicalis
• Alignment Length: 545
• Identity: 119/545 - (21%)
• Similarity: 171/545 - (31%)
• Gaps: 191/545 - (35%)

  Fly    54 ATRSRFMITDILAGAAAASAAAAAAAAALAAASSGGGRGSPTDSEREQSLVAQHHHHHQQQQQHH 118
            |||.:..:...:.||.||....|...         |..|...||..||.|.|
 Frog     3 ATREKVQLDMPIGGAQAAGVVEAVTC---------GLHGEMMDSHGEQRLTA------------- 45

  Fly   119 HHQQQQQQQQHQQAALQQYIVQQQQLLRFEREREREREREHYRERHSPPGNNPYAHHPMPPHLLA 183
                                   ..|..:...|:|:             |::|..:.|..|..|.
 Frog    46 -----------------------SDLPAYGCPRDRQ-------------GDHPNCNAPAGPESLG 74

  Fly   184 HFPPA-----HYAVLQQQQQQQQQQQHPHPHHLQLERERLEALHRHGHGLTGDPAQHLSHLSHLS 243
            ..|.|     .::||.                 .|:..:..:..||..|....|..::......:
 Frog    75 AAPLAVHRTTSFSVLD-----------------ILDPNKFNSKQRHCSGAYKPPGDYILRGEEKA 122

  Fly   244 H-------------------------QQHHPHLHHPMHD----ERSRSPLMLQQLGGNGGNNNNN 279
            .                         ::...:.|....|    |.|.||      |.:.....:.
 Frog   123 EGPDIATGQKAFLEEYESCKKSTEVIKEEGLYQHSATEDCQTQEFSPSP------GSDLEEEEDE 181

  Fly   280 NNNSSSASNNNNNNNNSASANSNIISGNSSSSNNNNGSGNGNMLLGGPGSSISGDQASTIDDSDS 344
            ..:....|..::|:..|..|..:..:|        ||.|...:..|.|..  |..|..|..:...
 Frog   182 EEDEEICSEESSNSTPSGLAERDPGAG--------NGQGEDALNTGAPAG--SNQQQPTGKNQQQ 236

  Fly   345 DDCGGKDD---DGDDSMKNGSSANGDSSSHLSLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLS 406
            .:..||..   .|.|| |:|                 |.|:||||||..||..||..|:..:|||
 Frog   237 QNQHGKPKRKRTGSDS-KSG-----------------KPRRARTAFTYEQLVALENKFKSTRYLS 283

  Fly   407 VQDRMELANKLELSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNY-----AAFQRLYGGATPYL 466
            |.:|:.||..|.|::.|||.|:||||||||:|.. |.:..|..|..     .:...|.||.:|..
 Frog   284 VCERLNLALSLSLTETQVKIWFQNRRTKWKKQNP-GADTSAPTGGSGHGGGGSGSVLGGGLSPLS 347

  Fly   467 SAWPYAAAAAAQSPHGATPSAIDIYYRQAAAAAAMQKPSLPASYRMYQSSIPPGM----SLPGMP 527
            .:.|.....|....||                              |.|..|.|:    .||.:|
 Frog   348 HSPPMGNPMALHGHHG------------------------------YPSHAPGGLMCTAQLPFLP 382

  Fly   528 APPPPGAAPMLSGYYAAAAAAAASA 552
            .|     |.:||.:..::.:..|.|
 Frog   383 GP-----AAVLSPFVLSSQSYGAPA 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B-H2	NP_523386.1	Homeodomain	381..437	CDD:459649	32/55 (58%)
nkx1-1	XP_002936812.1	Homeodomain	258..314	CDD:459649	32/55 (58%)