Protein Alignment Fim and SAC6

DIOPT Version :10

• Sequence 1: NP_728074.1
• Gene: Fim / 32721
• FlyBaseID: FBgn0024238
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_010414.3
• Gene: SAC6 / 851707
• SGDID: S000002536
• Length: 642
• Species: Saccharomyces cerevisiae
• Alignment Length: 637
• Identity: 247/637 - (38%)
• Similarity: 375/637 - (58%)
• Gaps: 44/637 - (6%)

  Fly    12 TVQEF------------KQNLEELIPNLDANKDGFIDLHELKDALNQVGFKLAGYQVREMIDEYK 64
            |:::|            ||...|.:     :|||.....|.::.|..||...:|   |..:|:|.
Yeast    21 TIEKFRAIDLDDKGWVEKQQALEAV-----SKDGDATYDEARETLKHVGVDASG---RVELDDYV 77

  Fly    65 GKQLTAFQGKLNLEEFEALCLDLKSKDVASTFKTVVSKKENLETLGGMSSI----SSEGTTHSVR 125
            |......:.|..........:...|..:.||..|.:..|..    |..:.|    |..||||::.
Yeast    78 GLVAKLRESKTGAAPQTTFNVAPNSTPIVSTAATGLQHKGK----GTQAKIIVAGSQTGTTHTIN 138

  Fly   126 LEEQLAFSDWINSNLGHDKDLQHLLPIDSEGKRLYLSIKDGILLCKIINHSCPDTIDERAIN--- 187
            .||:..|:..|||.|..|:|:..|||..::..:|:...:||::|.|:||.|.|||||.|.:|
Yeast   139 EEERREFTKHINSVLAGDQDIGDLLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPK 203

  Fly   188 -KKNLTVYREFENLTLALVSSQAIGCNIVNIDAHDLAKGKPHLVLGLLWQIIRIGLFSHITLDSC 251
             .|.|..::..||..:.:.|::||||.:||:.:.|:.:|:.||:|||:|||||.||.|.|.:...
Yeast   204 KGKELNNFQASENANIVINSAKAIGCVVVNVHSEDIIEGREHLILGLIWQIIRRGLLSKIDIKLH 268

  Fly   252 PGLAGLLFDNERLEDLMKMSPEAILLRWVNHHLERAGISRRCTNFQSDIVDSEIYSHLLKQIAGN 316
            |.|..||.|:|.||..:::.||.|||||.|:||::|..:||.|||..|:.|.|.|:.||.|:  :
Yeast   269 PELYRLLEDDETLEQFLRLPPEQILLRWFNYHLKQANWNRRVTNFSKDVSDGENYTILLNQL--D 331

  Fly   317 DADVNLDALRESDLQSRAEIMLQQAAKLNCRSFLTPQDVVNGVYKLNLAFVANLFNNHPGLDKPE 381
            .|..:...|:.:||..|||.:||.|.||:||.:|||..:|.|..||||||||:|||.||||: |.
Yeast   332 PALCSKAPLQTTDLMERAEQVLQNAEKLDCRKYLTPSSLVAGNPKLNLAFVAHLFNTHPGLE-PI 395

  Fly   382 QIEGLESIEE-----TREEKTYRNWMNSMGVAPHVNWLYSDLADGLVIFQLFDVIKPGIVNWSRV 441
            |.|....|||     .||.:.:..|:||:.|.|.|..|:.||.|||::.|.::.:.||.|::..|
Yeast   396 QEEEKPEIEEFDAEGEREARVFTLWLNSLDVDPPVISLFDDLKDGLILLQAYEKVMPGAVDFKHV 460

  Fly   442 HKR---FSPLRKFMEKLENCNYAVDLGKQLKFSLVGIAGQDLNDGNATLTLALIWQLMRAYTLSI 503
            :||   .:.:.:| :.|||.|||||||:...||||||.|.|:.|||..|||.|:|||||......
Yeast   461 NKRPASGAEISRF-KALENTNYAVDLGRAKGFSLVGIEGSDIVDGNKLLTLGLVWQLMRRNISIT 524

  Fly   504 LSRLANTGNPIIEKEIVQWVNNRLSEAGKQSQLRNFNDPAIADGKIVIDLIDAIKEGSINYELVR 568
            :..|:::|..:.:.:|::|..:::::.||.|.:|:|.|.|:::...::|:::.|..|.::|:||.
Yeast   525 MKTLSSSGRDMSDSQILKWAQDQVTKGGKNSTIRSFKDQALSNAHFLLDVLNGIAPGYVDYDLVT 589

  Fly   569 TSGTQEDNLANAKYAISMARKIGARVYALPEDITEVKPKMVMTVFACMMALD 620
            ...|:|:..|||:.|||:|||:||.::.:||||.||:.::::|..|.:|.|:
Yeast   590 PGNTEEERYANARLAISIARKLGALIWLVPEDINEVRARLIITFIASLMTLN 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fim	NP_728074.1	EFh	27..80	CDD:415501	13/52 (25%)
		CH_PLS_rpt1	104..248	CDD:409141	61/151 (40%)
		CH_PLS_rpt2	260..372	CDD:409144	55/111 (50%)
		CH_PLS_rpt3	389..504	CDD:409147	55/122 (45%)
		CH_PLS_rpt4	514..620	CDD:409150	37/105 (35%)
SAC6	NP_010414.3	SAC6	1..640	CDD:227401	246/634 (39%)