DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fim and AT5G48460

DIOPT Version :9

Sequence 1:	NP_728074.1	Gene:	Fim / 32721	FlyBaseID:	FBgn0024238	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_199657.1	Gene:	AT5G48460 / 834901	AraportID:	AT5G48460	Length:	654	Species:	Arabidopsis thaliana

Alignment Length:	594	Identity:	228/594 - (38%)
Similarity:	352/594 - (59%)	Gaps:	32/594 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LKDALNQVG-FKLAGYQVREMIDEYKGKQLTAFQGKLNLE-EFE---ALCLDLKSKDVASTFKTV 99
            :.|..:::| .|:.|.|  .:.:|.:...:..|...||.| :||   .:.|:|:    |.....:
plant    42 VSDLASRMGKSKVVGDQ--NLSNEERATLIQNFHPNLNDEVDFEFYLRIYLNLQ----AHVNAII 100

  Fly   100 VSKKENLETLGGMSSISSEGTT---HSVRLEEQLAFSDWINSNLGHDKDLQHLLPIDSEGKRLYL 161
            .|..:|      .|:.....||   |::...|:.::...||:.|..|:.|...|||:.....|:.
plant   101 GSGVKN------SSAFLKAATTTLLHTISDSEKSSYVAHINNYLSGDEFLNKCLPINPSSNDLFE 159

  Fly   162 SIKDGILLCKIINHSCPDTIDERAINKKN-LTVYREFENLTLALVSSQAIGCNIVNIDAHDLAKG 225
            ..|||:||||:||.:.|.||||||||.|: |..:...||.||.|.|::||||.:|||...|:.:|
plant   160 VAKDGVLLCKLINVAVPGTIDERAINTKSMLNPWERNENHTLCLNSAKAIGCTVVNIGTQDIIEG 224

  Fly   226 KPHLVLGLLWQIIRIGLFSHITLDSCPGLAGLLFDNERLEDLMKMSPEAILLRWVNHHLERAGIS 290
            :.|||||::.|||:|.|.:.:.|...|.|..|:.|::.:|:||.:.||.|||||:|..|.:....
plant   225 RRHLVLGVISQIIKIQLLADLNLKKTPQLVELVGDSKDVEELMSLPPEKILLRWMNFQLRKTEYK 289

  Fly   291 RRCTNFQSDIVDSEIYSHLLKQIAGNDADVNLDALRESDLQSRAEIMLQQAAKLNCRSFLTPQDV 355
            :..|||.||:.|:|.|::||..:|....:.:..|::.|  ..||:::|:.|.|:.||.:||.:|:
plant   290 KTVTNFSSDVKDAEAYTNLLNVLAPEHKNPSHLAVKSS--FERAKLVLEHADKMGCRRYLTAKDI 352

  Fly   356 VNGVYKLNLAFVANLFNNHPGLD-KPEQIEGLES----IEETREEKTYRNWMNSMGVAPHVNWLY 415
            |.|...|||||||::|.:..||. :.:||..||:    |:.:||||.:|.|:||...:.::|.::
plant   353 VEGSPNLNLAFVAHIFQHRNGLSTQTKQISFLENLADDIQISREEKAFRFWINSFDGSVYINNVF 417

  Fly   416 SDLADGLVIFQLFDVIKPGIVNWSRVHKRFSPLRKFMEKLENCNYAVDLGKQLKFSLVGIAGQDL 480
            .||.||.::.|..|.:.||||||....|  .|::...:|:||||..|.||||||||||.|||.|:
plant   418 EDLRDGWILLQTLDKVSPGIVNWKVSSK--PPIKLPFKKVENCNQVVKLGKQLKFSLVNIAGNDI 480

  Fly   481 NDGNATLTLALIWQLMRAYTLSILS--RLANTGNPIIEKEIVQWVNNRLSEAGKQSQLRNFNDPA 543
            ..||..|.||.:|||||...|.:|.  ||.:.|..|.:.:|::|.|.::...|.::::.:|.|.:
plant   481 VQGNKKLILAYLWQLMRYNILQLLKNLRLHSNGKEITDADILEWANAKVRNNGCKTRMYSFRDKS 545

  Fly   544 IADGKIVIDLIDAIKEGSINYELVRTSGTQEDNLANAKYAISMARKIGARVYALPEDITEVKPKM 608
            ::||...::|:.:::..|:|:.||....|.|:...||.|.||:|||:|..::.|||||.||..||
plant   546 LSDGVFFLELLSSVQPRSVNWSLVTNGVTDEEKKMNATYVISIARKLGCSIFLLPEDIIEVNQKM 610

  Fly   609 VMTVFACMM 617
            ::|:.|.:|
plant   611 MLTLTASIM 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fim	NP_728074.1	EF-hand_7	27..84	CDD:290234	12/48 (25%)
		EFh	27..80	CDD:298682	10/41 (24%)
		CH	127..237	CDD:278723	50/110 (45%)
		CH	271..370	CDD:278723	41/98 (42%)
		CH	396..497	CDD:214479	48/100 (48%)
		CH	517..619	CDD:214479	36/101 (36%)
AT5G48460	NP_199657.1	SAC6	53..619	CDD:227401	225/581 (39%)
		CH	125..236	CDD:278723	50/110 (45%)
		CH	270..367	CDD:278723	41/98 (42%)
		CH	398..498	CDD:214479	49/101 (49%)
		CH	520..621	CDD:214479	36/100 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2057
eggNOG	1	0.900	-	-		E2759_KOG0046
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	405	1.000	Inparanoid score	I459
OMA	1	1.010	-	-		QHG54335
OrthoDB	1	1.010	-	-		D312506at2759
OrthoFinder	1	1.000	-	-		FOG0000930
OrthoInspector	1	1.000	-	-		otm2525
orthoMCL	1	0.900	-	-		OOG6_101115
Panther	1	1.100	-	-	O	PTHR19961
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840