Protein Alignment Fim and PLS3

DIOPT Version :10

• Sequence 1: NP_728074.1
• Gene: Fim / 32721
• FlyBaseID: FBgn0024238
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_005023.2
• Gene: PLS3 / 5358
• HGNCID: 9091
• Length: 630
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 341/637 - (53%)
• Similarity: 433/637 - (67%)
• Gaps: 40/637 - (6%)

  Fly     7 VEQHQTVQEFKQNLEEL---IPNLDANKDGFIDLHELKDALNQVGFKLAGYQVRE-----MIDEY 63
            :::..|.|..|..|:||   ...:|.|.:|||..:||.:...:....|.||:|||     |:|..
Human     1 MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLMLDGD 65

  Fly    64 KGKQLTAFQGKLNLEEFEALCLDLKSKDVASTFKTVVSKKENLETLGGMSSISSEGTTHSVRLEE 128
            :.|     .||::.:||..:..::||.|:|.||:..:::||.:..|||.|.:|||||.||...||
Human    66 RNK-----DGKISFDEFVYIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYSEEE 125

  Fly   129 QLAFSDWINSNLGHDKDLQHLLPIDSEGKRLYLSIKDGILLCKIINHSCPDTIDERAINKKNLTV 193
            :.||.:|||..|.:|.|.:|::|::.....|:.::.|||:|||:||.|.||||||||||||.||.
Human   126 KYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERAINKKKLTP 190

  Fly   194 YREFENLTLALVSSQAIGCNIVNIDAHDLAKGKPHLVLGLLWQIIRIGLFSHITLDSCPGLAGLL 258
            :...|||.|||.|:.||||::|||.|.||..||||||||||||||:||||:.|.|.....||.||
Human   191 FIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALL 255

  Fly   259 FDNERLEDLMKMSPEAILLRWVNHHLERAGISRRCTNFQSDIVDSEIYSHLLKQIAGND------ 317
            .|.|.||:|||:|||.:||||.|.|||.:| .::..||.:||.||:.|.|||.|||...
Human   256 RDGETLEELMKLSPEELLLRWANFHLENSG-WQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEP 319

  Fly   318 -ADVNLDALRESDLQSRAEIMLQQAAKLNCRSFLTPQDVVNGVYKLNLAFVANLFNNHPGLDKPE 381
             .|:|:....|:|...|||.|||||.||.||.|:||.|||:|..||||||||||||.:|.|.|||
Human   320 RIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPE 384

  Fly   382 Q-------IEGLESIEETREEKTYRNWMNSMGVAPHVNWLYSDLADGLVIFQLFDVIK-PGIVNW 438
            .       :||     |||||:|:||||||:||.||||.||:||.|.|||.||::.|| |  |:|
Human   385 NQDIDWTLLEG-----ETREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVP--VDW 442

  Fly   439 SRVHK-RFSPLRKFMEKLENCNYAVDLGKQ-LKFSLVGIAGQDLNDGNATLTLALIWQLMRAYTL 501
            |:|:| .:..|...|:|||||||||:|||. .|||||||.||||||||.||||||:|||||.|||
Human   443 SKVNKPPYPKLGANMKKLENCNYAVELGKHPAKFSLVGIGGQDLNDGNQTLTLALVWQLMRRYTL 507

  Fly   502 SILSRLANTGNPIIEKEIVQWVNNRLSEAGKQSQLRNFNDPAIADGKIVIDLIDAIKEGSINYEL 566
            ::|..|.: |....:..||.|||..||||||.:.:::|.|..|:....|:||||||:.|.|||:|
Human   508 NVLEDLGD-GQKANDDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGCINYDL 571

  Fly   567 VRTSG-TQEDNLANAKYAISMARKIGARVYALPEDITEVKPKMVMTVFACMM 617
            |::.. |::|...|||||:||||:|||||||||||:.|||||||||||||:|
Human   572 VKSGNLTEDDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLM 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fim	NP_728074.1	EFh	27..80	CDD:415501	18/57 (32%)
		CH_PLS_rpt1	104..248	CDD:409141	84/143 (59%)
		CH_PLS_rpt2	260..372	CDD:409144	65/118 (55%)
		CH_PLS_rpt3	389..504	CDD:409147	79/117 (68%)
		CH_PLS_rpt4	514..620	CDD:409150	63/105 (60%)
PLS3	NP_005023.2	EFh	16..82	CDD:238008	22/70 (31%)
		CH_PLS_rpt1	101..245	CDD:409141	84/143 (59%)
		Actin-binding 1	109..382		154/273 (56%)
		CH_PLS3_rpt2	254..375	CDD:409177	67/121 (55%)
		CH_PLS3_rpt3	377..510	CDD:409180	86/139 (62%)
		Actin-binding 2	383..627		149/249 (60%)
		CH_PLS3_rpt4	519..630	CDD:409183	63/105 (60%)