Protein Alignment Fim and Lcp1

DIOPT Version :10

• Sequence 1: NP_728074.1
• Gene: Fim / 32721
• FlyBaseID: FBgn0024238
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001012044.1
• Gene: Lcp1 / 306071
• RGDID: 1308288
• Length: 627
• Species: Rattus norvegicus
• Alignment Length: 623
• Identity: 333/623 - (53%)
• Similarity: 422/623 - (67%)
• Gaps: 31/623 - (4%)

  Fly    15 EFKQNLEELIPNLDANKDGFIDLHELKDALNQVGFKLAGYQVREMIDEYKGKQLTAFQGKLNLEE 79
            |....|.|....:|.:.:|:|..:||.|........|.||:|||:.:...........||::.:|
  Rat     9 EEMMELREAFAKVDTDGNGYISCNELNDLFKAACLPLPGYRVREITENLMATGDLDQDGKISFDE 73

  Fly    80 FEALCLDLKSKDVASTFKTVVSKKENLETLGGMSSISSEGTTHSVRLEEQLAFSDWINSNLGHDK 144
            |..:...|||.:||.||:..::|||.:..:||.|..||.||.||...||:.||.:|||..|.:|.
  Rat    74 FIKVFHGLKSTEVAKTFRKAINKKEGICAIGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDP 138

  Fly   145 DLQHLLPIDSEGKRLYLSIKDGILLCKIINHSCPDTIDERAINKKNLTVYREFENLTLALVSSQA 209
            |.:|::|::.....|:.::.|||:|||::|.|.|||||||.||||.||.:...|||.|||.|:.|
  Rat   139 DCRHVIPMNPNTDDLFNAVGDGIVLCKMVNLSVPDTIDERTINKKKLTPFTIQENLNLALNSASA 203

  Fly   210 IGCNIVNIDAHDLAKGKPHLVLGLLWQIIRIGLFSHITLDSCPGLAGLLFDNERLEDLMKMSPEA 274
            |||::|||.|.||.:|||:||||||||:|:||||:.|.|.....|..||.:.|.||||||:|||.
  Rat   204 IGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEE 268

  Fly   275 ILLRWVNHHLERAGISRRCTNFQSDIVDSEIYSHLLKQIA--GNDAD-----VNLDALRESDLQS 332
            :||||.|:|||.||.: :.|||.:||.||:.|.|||:|:|  |::..     :::..|||.|...
  Rat   269 LLLRWANYHLENAGCT-KITNFSTDIKDSKAYYHLLEQVAPRGDEEGIPAVVIDMSGLREKDDIQ 332

  Fly   333 RAEIMLQQAAKLNCRSFLTPQDVVNGVYKLNLAFVANLFNNHPGLDKPEQ-------IEGLESIE 390
            |||.|||||.:|.||.|:|..|||.|..||||||:|||||.:|.|.|||.       :||
  Rat   333 RAECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNKYPALHKPENQDIDWGALEG----- 392

  Fly   391 ETREEKTYRNWMNSMGVAPHVNWLYSDLADGLVIFQLFDVIK-PGIVNWSRVHKRFSPLRKF--- 451
            |||||:|:||||||:||.|.||.|||||:|.||||||::.|| |  |:|:||::  .|..|.
  Rat   393 ETREERTFRNWMNSLGVNPGVNHLYSDLSDALVIFQLYEKIKVP--VDWNRVNR--PPYPKLGGN 453

  Fly   452 MEKLENCNYAVDLGK-QLKFSLVGIAGQDLNDGNATLTLALIWQLMRAYTLSILSRLANTGNPII 515
            |:||||||||||||| |.|||||||||||||:||.||||||:|||||.|||:||..:.. |..:.
  Rat   454 MKKLENCNYAVDLGKNQAKFSLVGIAGQDLNEGNRTLTLALVWQLMRRYTLNILEDIGG-GQKVN 517

  Fly   516 EKEIVQWVNNRLSEAGKQSQLRNFNDPAIADGKIVIDLIDAIKEGSINYELVRTSG-TQEDNLAN 579
            :..||.|||..|.||.|.|.:.:|.||.|:....|:||||||:.|||||:|::|.. ..|:.|.|
  Rat   518 DDIIVNWVNTTLKEAQKSSSITSFKDPKISTSLPVLDLIDAIQPGSINYDLLKTENLDDEEKLNN 582

  Fly   580 AKYAISMARKIGARVYALPEDITEVKPKMVMTVFACMM 617
            |||||||||||||||||||||:.||.||||||||||:|
  Rat   583 AKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLM 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fim	NP_728074.1	EFh	27..80	CDD:415501	14/52 (27%)
		CH_PLS_rpt1	104..248	CDD:409141	78/143 (55%)
		CH_PLS_rpt2	260..372	CDD:409144	64/118 (54%)
		CH_PLS_rpt3	389..504	CDD:409147	82/119 (69%)
		CH_PLS_rpt4	514..620	CDD:409150	65/105 (62%)
Lcp1	NP_001012044.1	EFh	13..79	CDD:238008	18/65 (28%)
		CH_PLS_rpt1	98..242	CDD:409141	78/143 (55%)
		CH_PLS2_rpt2	251..375	CDD:409176	68/124 (55%)
		CH_SF	374..507	CDD:469584	89/141 (63%)
		CH_PLS2_rpt4	511..625	CDD:409182	66/111 (59%)