Protein Alignment Fim and lcp1

DIOPT Version :10

• Sequence 1: NP_728074.1
• Gene: Fim / 32721
• FlyBaseID: FBgn0024238
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_571395.2
• Gene: lcp1 / 30583
• ZFINID: ZDB-GENE-991213-5
• Length: 624
• Species: Danio rerio
• Alignment Length: 626
• Identity: 332/626 - (53%)
• Similarity: 420/626 - (67%)
• Gaps: 30/626 - (4%)

  Fly    11 QTVQEFKQNLEELIPNLDANKDGFIDLHELKDALNQVGFKLAGYQVREMIDEYKGKQLTAFQGKL 75
            |...|..:.|.|....:|.:.:|.|...||..........|.||:|||:|.|..........||:
Zfish     5 QISAEEMEELREAFTKVDVDGNGHISTDELNALFKAANLPLPGYRVREIIQEISRTMDLNQDGKI 69

  Fly    76 NLEEFEALCLDLKSKDVASTFKTVVSKKENLETLGGMSSISSEGTTHSVRLEEQLAFSDWINSNL 140
            ..:||..:..||||.:||.||:..::|||.:.::.|.|..|  ||.||...||::||.:|:|..|
Zfish    70 TFDEFAKVVHDLKSSEVAKTFRKAINKKEGICSVAGTSEQS--GTQHSYSEEEKVAFVNWVNKAL 132

  Fly   141 GHDKDLQHLLPIDSEGKRLYLSIKDGILLCKIINHSCPDTIDERAINKKNLTVYREFENLTLALV 205
            ..|.|.||:||:|.....|:.::.|||:|||:||.|.|||||||.||||.||.:...|||.|||.
Zfish   133 EKDPDCQHVLPMDPSTDDLFTAVGDGIVLCKMINLSVPDTIDERTINKKKLTPFTIQENLNLALN 197

  Fly   206 SSQAIGCNIVNIDAHDLAKGKPHLVLGLLWQIIRIGLFSHITLDSCPGLAGLLFDNERLEDLMKM 270
            |:.||||::|||.|.||.:|:.|||||||||:|:||||:.|.:.....|..||.|.|.||||:|:
Zfish   198 SASAIGCHVVNIGAEDLKEGRQHLVLGLLWQVIKIGLFADIEISRNEALIALLRDGESLEDLVKL 262

  Fly   271 SPEAILLRWVNHHLERAGISRRCTNFQSDIVDSEIYSHLLKQIA--GND-----ADVNLDALRES 328
            |||.:||||.|:|||.||.. :..||.|||.||:.|.::|.|:|  |::     ..:::..:||.
Zfish   263 SPEELLLRWANYHLEEAGCP-KINNFSSDIKDSKAYYNILNQVAPKGDEEGIPAIPIDISGIREK 326

  Fly   329 DLQSRAEIMLQQAAKLNCRSFLTPQDVVNGVYKLNLAFVANLFNNHPGLDKPE-------QIEGL 386
            |...|||.||:||.:|.||.|:|..|||.|..|||||:||||||.:|.|.|||       .|||
Zfish   327 DDLKRAECMLEQADRLGCRQFVTATDVVRGNPKLNLAYVANLFNKYPALKKPENQDIDWSSIEG- 390

  Fly   387 ESIEETREEKTYRNWMNSMGVAPHVNWLYSDLADGLVIFQLFDVIK-PGIVNWSRVHK-RFSPLR 449
                |||||:|:||||||:||.|.||.||.||||.||||||::.|| |  |:|.:|:| .:..|.
Zfish   391 ----ETREERTFRNWMNSLGVNPRVNHLYVDLADALVIFQLYEKIKVP--VDWDKVNKPPYPKLG 449

  Fly   450 KFMEKLENCNYAVDLG-KQLKFSLVGIAGQDLNDGNATLTLALIWQLMRAYTLSILSRLANTGNP 513
            ..|:|||||||||:|| |:.|||||||||||||:||.||||||:|||||.|||:||..|.: |..
Zfish   450 SNMKKLENCNYAVELGKKEAKFSLVGIAGQDLNEGNRTLTLALLWQLMRRYTLNILEDLGD-GQK 513

  Fly   514 IIEKEIVQWVNNRLSEAGKQSQLRNFNDPAIADGKIVIDLIDAIKEGSINYELVRTSG-TQEDNL 577
            ||::.||||||..|::||| ..:..|.|.:|:....|:||||||:.|||.|:|::... |.|:.|
Zfish   514 IIDETIVQWVNETLTQAGK-GTISGFKDGSISSSMPVLDLIDAIQPGSIRYDLLKAEDLTDEEKL 577

  Fly   578 ANAKYAISMARKIGARVYALPEDITEVKPKMVMTVFACMMA 618
            .||||||||||||||||||||||:.|||||||||||||:||
Zfish   578 NNAKYAISMARKIGARVYALPEDLVEVKPKMVMTVFACLMA 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fim	NP_728074.1	EFh	27..80	CDD:415501	15/52 (29%)
		CH_PLS_rpt1	104..248	CDD:409141	78/143 (55%)
		CH_PLS_rpt2	260..372	CDD:409144	60/118 (51%)
		CH_PLS_rpt3	389..504	CDD:409147	79/117 (68%)
		CH_PLS_rpt4	514..620	CDD:409150	67/106 (63%)
lcp1	NP_571395.2	EFh	13..79	CDD:238008	19/65 (29%)
		CH_PLS_rpt1	98..240	CDD:409141	78/143 (55%)
		Actin-binding 1. /evidence=ECO:0000255	118..373		135/255 (53%)
		CH_PLS2_rpt2	249..373	CDD:409176	64/124 (52%)
		CH_SF	372..505	CDD:469584	87/139 (63%)
		Actin-binding 2. /evidence=ECO:0000255	392..621		149/231 (65%)
		CH_PLS2_rpt4	509..622	CDD:409182	68/112 (61%)