Protein Alignment Fim and fim1

DIOPT Version :9

• Sequence 1: NP_728074.1
• Gene: Fim / 32721
• FlyBaseID: FBgn0024238
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_596289.1
• Gene: fim1 / 2539765
• PomBaseID: SPBC1778.06c
• Length: 614
• Species: Schizosaccharomyces pombe
• Alignment Length: 621
• Identity: 247/621 - (39%)
• Similarity: 364/621 - (58%)
• Gaps: 48/621 - (7%)

  Fly    20 LEELIPNLDANKDGFID----LHELKDALNQVGFKLAGY-QVREMIDEYKGKQLTAFQGKLNLEE 79
            |.:....||.:..|::|    :...:|:      |...| :|||.|.|..    ....|::..|:
pombe    21 LTDQFNKLDVDGKGYLDQPTTIKAFEDS------KKGSYDEVREAIREVN----VDSSGRVEPED 75

  Fly    80 FEALCLDLKSKDVASTFKTVVSKKENLETLGGMSSISSEGTTHSVRLEEQLAFSDWINSNLGHDK 144
            |..:...|| |.|..|    ..||..:...|..||:|     |::..||:..|...|||.|..|.
pombe    76 FVGIFNVLK-KGVEGT----EVKKGRITIKGSSSSVS-----HTINEEERREFIKHINSVLAGDP 130

  Fly   145 DLQHLLPIDSEGKRLYLSIKDGILLCKIINHSCPDTIDERAINK----KNLTVYREFENLTLALV 205
            |:...:||::|....:...|||::|.|:||.|.|||||||.:||    |.|..::..||..:.:.
pombe   131 DVGSRVPINTETFEFFDQCKDGLILSKLINDSVPDTIDERVLNKQRNNKPLDNFKCIENNNVVIN 195

  Fly   206 SSQAI-GCNIVNIDAHDLAKGKPHLVLGLLWQIIRIGLFSHITLDSCPGLAGLLFDNERLEDLMK 269
            |::|: |.:|.||.|.|:.:|:.||:|||:|||||.||...|.:...|.|..||.::|.|:..::
pombe   196 SAKAMGGISITNIGAGDILEGREHLILGLVWQIIRRGLLGKIDITLHPELYRLLEEDETLDQFLR 260

  Fly   270 MSPEAILLRWVNHHLERAGISRRCTNFQSDIVDSEIYSHLLKQIAGNDADVNLDALRESDLQSRA 334
            :.||.|||||.|:||:.|...|..:||..|:.|.|.|:.||.|:|....  :...|:.:|:..||
pombe   261 LPPEKILLRWFNYHLKAANWPRTVSNFSKDVSDGENYTVLLNQLAPELC--SRAPLQTTDVLQRA 323

  Fly   335 EIMLQQAAKLNCRSFLTPQDVVNGVYKLNLAFVANLFNNHPGL------DKPEQIEGLESIEETR 393
            |.:||.|.||:||.:|||..:|.|..||||||||:|||.||||      :||| ||..:: |..|
pombe   324 EQVLQNAEKLDCRKYLTPTAMVAGNPKLNLAFVAHLFNTHPGLEPLNEEEKPE-IEPFDA-EGER 386

  Fly   394 EEKTYRNWMNSMGVAPHVNWLYSDLADGLVIFQLFDVIKPGIVNWSRVHKRFSP-----LRKFME 453
            |.:.:..|:||:.|.|.::..:::|.|||::.|.:|.|.|..|||.:|:|  :|     :.:| :
pombe   387 EARVFTLWLNSLDVTPSIHDFFNNLRDGLILLQAYDKITPNTVNWKKVNK--APASGDEMMRF-K 448

  Fly   454 KLENCNYAVDLGKQLKFSLVGIAGQDLNDGNATLTLALIWQLMRAYTLSILSRLANTGNPIIEKE 518
            .:|||||||||||...||||||.|.|:.||:.||||||:||:||......|..|:..|..:.:.:
pombe   449 AVENCNYAVDLGKNQGFSLVGIQGADITDGSRTLTLALVWQMMRMNITKTLHSLSRGGKTLSDSD 513

  Fly   519 IVQWVNNRLSEAGKQSQLRNFNDPAIADGKIVIDLIDAIKEGSINYELVRTSGTQEDNLANAKYA 583
            :|.|.|:..::.||.||:|:|.||:|:.|..|:|::..||...::|.||....|:|..:.||:.|
pombe   514 MVAWANSMAAKGGKGSQIRSFRDPSISTGVFVLDVLHGIKSEYVDYNLVTDGSTEELAIQNARLA 578

  Fly   584 ISMARKIGARVYALPEDITEVKPKMVMTVFACMMAL 619
            ||:|||:||.::.|||||..|:|::|:.....:||:
pombe   579 ISIARKLGAVIFILPEDIVAVRPRLVLHFIGSLMAV 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fim	NP_728074.1	EF-hand_7	27..84	CDD:290234	15/61 (25%)
		EFh	27..80	CDD:298682	14/57 (25%)
		CH	127..237	CDD:278723	48/114 (42%)
		CH	271..370	CDD:278723	47/98 (48%)
		CH	396..497	CDD:214479	49/105 (47%)
		CH	517..619	CDD:214479	41/101 (41%)
fim1	NP_596289.1	SAC6	1..614	CDD:227401	246/619 (40%)
		CH	113..233	CDD:237981	52/119 (44%)
		CH	262..364	CDD:237981	50/103 (49%)
		CH	389..493	CDD:214479	50/106 (47%)
		CH	513..611	CDD:278723	40/97 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	109	1.000	Domainoid score	I1624
eggNOG	1	0.900	-	-		E2759_KOG0046
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80174
Inparanoid	1	1.050	402	1.000	Inparanoid score	I376
OMA	1	1.010	-	-		QHG54335
OrthoFinder	1	1.000	-	-		FOG0000930
OrthoInspector	1	1.000	-	-		oto100725
orthoMCL	1	0.900	-	-		OOG6_101115
Panther	1	1.100	-	-	LDO	PTHR19961
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2112
SonicParanoid	1	1.000	-	-		X500
TreeFam	1	0.960	-	-
	14	13.860