DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fim and Y73B3B.1

DIOPT Version :9

Sequence 1:	NP_728074.1	Gene:	Fim / 32721	FlyBaseID:	FBgn0024238	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_508051.1	Gene:	Y73B3B.1 / 190640	WormBaseID:	WBGene00022223	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	363	Identity:	123/363 - (33%)
Similarity:	197/363 - (54%)	Gaps:	68/363 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 LRESDLQSRAEIMLQQAAKLNCRSFLTPQDVVNGVYKLNLAFVANLFNNHPGLDKPEQIEGLESI 389
            |.|..::.|..:|...||::: ..|.|....:..| :|:.......|.::.|..|   ::|.::|
Worm     4 LEEYSIEERVRVMFGSAAEVS-NDFRTQIRTIGDV-ELDEKHRICKFTSYDGKLK---LQGDQNI 63

  Fly   390 EETREEKTYRNWMNSMGVAPHVNWL-------------------YSDL-----ADGLVIFQLFDV 430
             ..|.:|.:...:....:...:|:|                   :|:|     .||:...:.::.
Worm    64 -SARSKKQWPIRVTLAELTGFMNYLVEKTKDTIEPVVAAKLFREFSELEGEGRTDGVYYKRFYNQ 127

  Fly   431 IKPG---IVNWS-----RVHKRFSP--LRKFMEKLENC-NYAVDLGKQL--------KFSLVG-- 474
            :.|.   :|::|     ||...|:.  ...|:.::... :..:|.||::        |.:|.|
Worm   128 LAPNMAKLVDYSIEERLRVMFGFAAEVFDDFLAQIRTLGDVELDEGKRISKFTSTDGKLNLEGDH 192

  Fly   475 ----------------IAGQDLNDGNATLTLALIWQLMRAYTLSILSRLANTGNPI-IEKEIVQW 522
                            ..|:.:.|||..|||||:||||||||||:|::...:|:.: .:|:||.|
Worm   193 SHAARMKRRCAEYRNAYRGRHIYDGNQILTLALVWQLMRAYTLSVLAQYTQSGDSLPTDKDIVAW 257

  Fly   523 VNNRLSEAGKQSQLRNFNDPAIADGKIVIDLIDAIKEGSINYELVRTSGTQEDNLANAKYAISMA 587
            ||.:|..:||.:.:|:|.||||:|||:|:||||:||...|::.||::..:.||.::||||||:..
Worm   258 VNEKLKNSGKSTSIRSFQDPAISDGKVVLDLIDSIKPNVIDHSLVKSGKSNEDKMSNAKYAITCG 322

  Fly   588 RKIGARVYALPEDITEVKPKMVMTVFACMMALDYVPNM 625
            |||||::|||||||.|||||||:|||||:||.||:|:|
Worm   323 RKIGAKIYALPEDIVEVKPKMVLTVFACLMARDYLPDM 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fim	NP_728074.1	EF-hand_7	27..84	CDD:290234
		EFh	27..80	CDD:298682
		CH	127..237	CDD:278723
		CH	271..370	CDD:278723	10/44 (23%)
		CH	396..497	CDD:214479	32/161 (20%)
		CH	517..619	CDD:214479	61/101 (60%)
Y73B3B.1	NP_508051.1	SPK	<1..59	CDD:214732	13/59 (22%)
		SPK	79..190	CDD:214732	18/110 (16%)
		CH	249..354	CDD:366016	61/104 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162659
Domainoid	1	1.000	140	1.000	Domainoid score	I2952
eggNOG	1	0.900	-	-		E2759_KOG0046
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138895at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750