DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vcp and TER94

DIOPT Version :9

Sequence 1:	NP_958889.1	Gene:	vcp / 327197	ZFINID:	ZDB-GENE-030131-5408	Length:	806	Species:	Danio rerio
Sequence 2:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	800	Identity:	663/800 - (82%)
Similarity:	738/800 - (92%)	Gaps:	6/800 - (0%)

- Green bases have known domain annotations that are detailed below.

Zfish     8 KNDDLSTAILKQKNRPNRLIVDESINEDNSVVSLSQAKMDELQLFRGDTVLLKGKKRRETVCIVL 72
            |.:||:|||||:|:|||||||:|:.|:|||||||||||||||||||||||:||||:|:|||||||
  Fly    30 KREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDELQLFRGDTVILKGKRRKETVCIVL 94

Zfish    73 SDDTCSDEKVRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKP 137
            |||||.|||:||||||||||.|.|.||:|:|.|||||||||:.:||||::.||:||||||:||||
  Fly    95 SDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDESTEGVTGNLFEIYLKP 159

Zfish   138 YFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVG 202
            |||||||||..||.|:||..||.:|||||.|||.|||||||:|||.|:|:|||||:||||||.||
  Fly   160 YFLEAYRPIHMGDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAVG 224

Zfish   203 YDDIGGVRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFF 267
            ||||||.||||||||||||||||||:||||||||||||||:||||||||||||||||||||||||
  Fly   225 YDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFF 289

Zfish   268 LINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLM 332
            |||||||||||||||||||||||||||||:||||||||:|||||||:||||||||||||||||||
  Fly   290 LINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVSQLLTLM 354

Zfish   333 DGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLE 397
            ||:|:.:|:|||||||||||||||||||||||||:||||||||||||:|:||||||||.||||||
  Fly   355 DGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMKLHDDVDLE 419

Zfish   398 QVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPS 462
            |:|.|:|||||||||:||||||||.||:|||||||||:.|||||:.||||||::||:|:::|:||
  Fly   420 QIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKSSPS 484

Zfish   463 ALRETVVEVPNITWEDIGGLDDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLL 527
            |||||||||||.||.|||||:.||:|||||||||||||||||||||.||:|||||||||||||||
  Fly   485 ALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLL 549

Zfish   528 AKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNVGD 592
            ||||||||||||||:||||||||||||||||||:||||||.||||||||||||||||||||||||
  Fly   550 AKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGD 614

Zfish   593 GGGAADRVINQILTEMDGMSSKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRIAIL 657
            .||||||||||||||||||.:||||||||||||||||||||||||||||||||||||:|||.|||
  Fly   615 AGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAIL 679

Zfish   658 KANLRKSPISKDVDLDFLAKMTNGFSGADLTEICQRACKLAIRESIENEIRRERERQTNP-SAME 721
            ||||||||::|:|||.::||:|.||||||||||||||||||||::||.|||||:||..|. |||:
  Fly   680 KANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNSAMD 744

Zfish   722 VEEDDPVPEIRKDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFG-SFRFPSSNQGGSGPSQ 785
            ::||||||||...||||||:|||||||||||||||||||||||||||| :||||    |.:|.:.
  Fly   745 MDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQTLQQSRGFGQNFRFP----GQTGNTS 805

Zfish   786 GSSGGGGGNVFNEDNDDDLY 805
            ||......|...::.|||||
  Fly   806 GSGNNLPVNSPGDNGDDDLY 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vcp	NP_958889.1	CDC48	25..764	CDD:273521	630/739 (85%)
		CDC48_N	25..107	CDD:280513	66/81 (81%)
		CDC48_2	131..191	CDD:215011	44/59 (75%)
		AAA	241..370	CDD:278434	118/128 (92%)
		P-loop_NTPase	452..>534	CDD:304359	69/81 (85%)
		AAA	514..647	CDD:278434	126/132 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		11/19 (58%)
		Vps4_C	<718..760	CDD:286426	34/41 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806		15/38 (39%)
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	630/739 (85%)
		CDC48_N	47..129	CDD:280513	66/81 (81%)
		CDC48_2	153..213	CDD:215011	44/59 (75%)
		AAA	263..392	CDD:278434	118/128 (92%)
		AAA	536..669	CDD:278434	126/132 (95%)
		Vps4_C	<741..783	CDD:286426	34/41 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596068
Domainoid	1	1.000	264	1.000	Domainoid score	I1875
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5168
Inparanoid	1	1.050	1332	1.000	Inparanoid score	I140
OMA	1	1.010	-	-		QHG60945
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		otm25087
orthoMCL	1	0.900	-	-		OOG6_100525
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R182
SonicParanoid	1	1.000	-	-		X1760
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800