Protein Alignment f and ESPN

DIOPT Version :10

• Sequence 1: NP_001036284.1
• Gene: f / 32718
• FlyBaseID: FBgn0262111
• Length: 1918
• Species: Drosophila melanogaster
• Sequence 2: XP_011540533.1
• Gene: ESPN / 83715
• HGNCID: 13281
• Length: 1341
• Species: Homo sapiens
• Alignment Length: 1497
• Identity: 300/1497 - (20%)
• Similarity: 494/1497 - (32%)
• Gaps: 412/1497 - (27%)

  Fly   349 GGMGQVGQMYHPGSVSGSERPNGGALALHYAAARGCLDCVQLLVAASVDICYFSTINVKKGLLGR 413
            |.:..:..::..|.:..|.|....||.:|:||..|.|.|::.||..:
Human    13 GELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEA------------------ 59

  Fly   414 MTTSLTSYRRSKQKSKSNNDIHTIIATEVVTAAILSSSVH-------SSSTGSEIGDGGQGNTSL 471
               :|.:..|::..:...:|              .|::.|       .|..|..:.|......::
Human    60 ---ALPAAARARNGATPAHD--------------ASATGHLACLQWLLSQGGCRVQDKDNSGATV 107

  Fly   472 IEEAAAQDQSSEEQDRQHQHAKDPLAQTEMNHHPHSHHQRKSAVEVVRQQMDDDGDQDSNDDDET 536
            :..||............|....||.|.|:|...|..:...|.....:|..:            |.
Human   108 LHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV------------EH 160

  Fly   537 MPMMSGVGRKEQNNRRSVVSANTQMDNDVTPVYLAAQEGHLEVLKFLVLEAGGSLYVRARDGMAP 601
            .|  .||              |.|..|..||:|||.|||||||.::||.|.|...:.||.|||.|
Human   161 YP--EGV--------------NAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTP 209

  Fly   602 IHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGHLSVVRWLLNHGAKLSLDKYGKS 666
            :|||:|||....:.|:|....|..:.:|.||||.:||||||||..|:.|||.||.::|.|.:|.:
Human   210 LHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGGT 274

  Fly   667 PINDAAENQQVECLNVLVQHGTSV--------------DYNGKSSSQRH-KSQQQLHQQHQ---- 712
            |::|||||.::||..:||.:|..:              |:||.|...|: ::.:.|..:|:
Human   275 PLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSR 339

  Fly   713 ----QQQQQQQQQHLSSSCNS------NSNSSKQTSRSNTIKSKSSSTLSSDVEPFYLHPPALAG 767
                :.:.:|....:||...:      |.:.|..||..:...|.|||..|...:    |||  .|
Human   340 DPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQ----HPP--CG 398

  Fly   768 GSGGSGMGLGMGMGM---GMGMSMGL--------------------------------------- 790
            .|......:...|.|   .:|:..|.
Human   399 LSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPPPPPPGTQLPPPPPGYPAPKPPVG 463

  Fly   791 ---------------------------------GISRKNSDALYSQQSRSSSEKLYNGS--SSLG 820
                                             |:.|::|    |::.|:.|::...|.  ..||
Human   464 PQAADIYMQTKNKLRHVETEALKKELSSCDGHDGLRRQDS----SRKPRAFSKQPSTGDYYRQLG 524

  Fly   821 GNPGGNSSSGGGGVGGGGGSGGALLPN----DGLYVNPMRNGGMYNTPSPNGSISGESFFLHDPQ 881
            ..||...::   ..|.......||||.    :|...:|..:..:...|.|......|:.....|
Human   525 RCPGETLAA---RPGMAHSEEAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPP- 585

  Fly   882 DIIYNRVRDLFVDS---DC-----SSS-----VKQHGKSHAHQLLQSKAGNAMTIQADVHSSSSG 933
                  ...|.::|   .|     |||     |.:|.||.....:.|..|:...:.|::.:..|.
Human   586 ------APPLPLESAGPGCGQRRSSSSTGKVRVLRHRKSTKSFNMMSPTGDNSELLAEIKAGKSL 644

  Fly   934 AGSGSDESV-SISSSFNSPKQQQQLRSQSFNRHGS---SSNISASGNIKNNNYKAHKGKPSNQNG 994
            ..:...:.: ::.|....|..|......|.:...|   |....|:|.....|.......|:....
Human   645 KPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAP 709

  Fly   995 GGDHDYEDIYLVREESRKQHQQQQQHQLQQQQQLQHQATQQQQQQQQQQQQLQHKYNVGRSRSRD 1059
            |...|.|.:....:|..:...:.::..:.::.||:    .|::::|:::..........|...|.
Human   710 GVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLK----MQEEEEQRRKLTAASSCCYPREGWRY 770

  Fly  1060 SGSHSRSASASSTRSTDIVLQYSNHHLNNKRNMNNNSNMNN-------SSSNIAQSSSSNNNNNS 1117
            |..|:..........|:..:......:.|.:.::....:..       ....:...|::.:....
Human   771 SREHNAILGPFGELMTEADILRIEQQIENLQVLHKAQKLEARLEQLELELEQLLPISAALSAPRF 835

  Fly  1118 LLNRNKSH---SIIGLHSSKYESSLKDNYSAKNVNLKNQLLN-GG--------IKSDTYESVCPP 1170
            .::..:.|   :.:....||..:.||        |:...|.. ||        :.:||.:.:.|.
Human   836 TVDPRRMHGRAASLPAWCSKISTLLK--------NMATLLAALGGRPAHLAELLTADTGQPLAPL 892

  Fly  1171 EDVAER-----TKQTHKNSMIRNNLADASSNNNTSGSINNISNIGNMNGGNQSSRNLKRVSSAP- 1229
            .|....     ..::|..|..|..:|            ..|...|......:::..|:...:||
Human   893 PDAPWLPGPLCLGRSHSLSWCREAVA------------REILECGVSVQHLRATYELRARGAAPA 945

  Fly  1230 --PMQNLAVVNGPPPPPLPPPLRAPVQQQ-----RNNLSVDQPNSMTGNNGIYKKNVFGPNQGPT 1287
              |.:.       ||.....|.|.|:.::     |:.    ||::...:..:......| ..||.
Human   946 RCPRRK-------PPQSAGAPGREPILEEDYVAARSG----QPSAAAAHGPLVDWEPLG-TLGPP 998

  Fly  1288 NANGTGGAAPPP--VPAPNPVATEAVDSDSGLEVVEE-----------------PSLRPSELVRG 1333
            .......|.|.|  :....|:.|:.......|::.:|                 |..|....:||
Human   999 EVQDRQAALPEPEQLARRPPLCTKLRGVQDYLDLRKERIVYLFLEHWRRWACRGPGRRAQARLRG 1063

  Fly  1334 NHNRTMSTISANKKAKLLNAGSTNGSSIAASSDDSQSRYGGSVHAANGSAANGHFYGYSEGNKNQ 1398
            ...| ::...|....:..:|.....|:..|.|.|.:.|.......|.|... ||:...
Human  1064 LLPR-VAAAGAGPGLEATDAPRLPASNSEAHSPDERLRQLLRQRQAVGKLL-GHWRSL------- 1119

  Fly  1399 GSNGNGNGNGNGGGGNYHSHPNQPHYATG--QPHQYTPSLYGGGSSAEDHYE------------- 1448
                            ....|..|..|.|  .|..:.|.|.||   |..||:
Human  1120 ----------------LRRVPASPGLAHGLYWPQHFLPPLDGG---APPHYDSLTLDLFMLGYFQ 1165

  Fly  1449 -----LTQQQQQIYGETHL---PSGQRTGGP-----NLVNKQLVLPFVPPSFPNKSQDGVTHLIK 1500
                 |::::::.   .||   ....|.|..     .|.:: :||..|.......| ||...|
Human  1166 LLEMGLSREERKF---RHLLCYEMFDRLGSHPWERIRLFHR-VVLEEVEAGRRGWS-DGFEDL-- 1223

  Fly  1501 PSEYLKSISIDKRSCPSSARSTDTEDYMQIQIAQQQSHPHQHQHHPHPHPHPHHPHQLHGMGEQP 1565
             ........::....|.. ::.:.|:..:.|...:::.|.|....|...|....|         .
Human  1224 -RHRFFGNGLEAEPAPEE-QAKEKEEEGKEQERTEEAAPFQTGDPPEGQPEALAP---------A 1277

  Fly  1566 PLPPPPPPLPHGMLPPQPPMGPPMGVAGGQDATMSGKSHKPKKPHGSAPNSQDTATRKQHQPLSA 1630
            |.|||||          ||..||                    |...:|.|:..|    ..||..
Human  1278 PQPPPPP----------PPAAPP--------------------PTSDSPGSEAPA----EDPLEL 1308

  Fly  1631 IS 1632
            :|
Human  1309 VS 1310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
f	NP_001036284.1	ANK repeat	371..399	CDD:293786	10/27 (37%)
		ANKYR	<558..695	CDD:440430	69/150 (46%)
		ANK repeat	566..595	CDD:293786	16/28 (57%)
		ANK repeat	597..629	CDD:293786	13/31 (42%)
		ANK repeat	631..660	CDD:293786	18/28 (64%)
		ANK repeat	663..691	CDD:293786	12/41 (29%)
ESPN	XP_011540533.1	ANKYR	2..277	CDD:440430	94/326 (29%)
		ANK repeat	39..67	CDD:293786	9/48 (19%)
		ANK repeat	69..101	CDD:293786	6/45 (13%)
		ANK repeat	103..135	CDD:293786	6/31 (19%)
		ANK repeat	137..169	CDD:293786	9/59 (15%)
		ANK repeat	171..203	CDD:293786	17/31 (55%)
		PLN03192	<196..365	CDD:215625	59/168 (35%)
		ANK repeat	239..269	CDD:293786	19/29 (66%)
		ANK repeat	271..302	CDD:293786	12/30 (40%)
		WH2	627..652	CDD:460490	3/24 (13%)