DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment f and espn

DIOPT Version :9

Sequence 1:	NP_001036284.1	Gene:	f / 32718	FlyBaseID:	FBgn0262111	Length:	1918	Species:	Drosophila melanogaster
Sequence 2:	XP_009302528.1	Gene:	espn / 567061	ZFINID:	ZDB-GENE-081105-173	Length:	898	Species:	Danio rerio

Alignment Length:	1514	Identity:	267/1514 - (17%)
Similarity:	412/1514 - (27%)	Gaps:	759/1514 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 GALALHYAAARGCLDCVQLLVAASVDICYFSTINVKKGLLGRMTTSLTSYRRSKQKSKSNNDIHT 436
            ||..:|:||..|.|.|::.||..:                |....||.        ....:..|.
Zfish    36 GATPVHHAARAGKLTCLRYLVDEA----------------GLPANSLA--------RNGASPAHD 76

  Fly   437 IIATEVVTAAILSSSVHSSSTGSEIGDGGQGNTSLIE------EAAAQDQSSEEQDRQHQHAKDP 495
            ..||                          ||.:.::      ...|.|:.|......|..::
Zfish    77 AAAT--------------------------GNLTCLQWLVTHGGCRAADKDSSGATVLHLASR-- 113

  Fly   496 LAQTEMNHHPHSHHQRKSAVEVVRQQM-DDDGDQDSNDDDETMPMMSGVGRKEQNNRRSVVS--- 556
                      .|||      |::...: .::||.....|...:|:.....:.:..:.|.::.
Zfish   114 ----------FSHH------EIIDWLLKSEEGDPTVATDTGALPVHYAAAKGDLPSLRLLLEHSP 162

  Fly   557 --ANTQMDNDVTPVYLAAQEGHLEVLKFLVLEAGGSLYVRARDGMAPIHAASQMGCLDCLKWMVQ 619
              .|.|..|..||:|||.|||||||:::||.:.|....:||.|||.|:|||:|||....:.|::.
Zfish   163 QVVNFQTKNGATPLYLACQEGHLEVVQYLVKDCGAEPSIRANDGMTPLHAAAQMGHNTVIVWLMS 227

  Fly   620 DQGVDPNLRDGDGATPLHFAASRGHLSVVRWLLNHGAKLSLDKYGKSPINDAAENQQVECLNVLV 684
            ...:..:.||.||||.:||||||||..|:.|||.||.::..|.:|.:|::|||||.::||..:||
Zfish   228 FTEISLSDRDNDGATAMHFAASRGHAKVLSWLLLHGGEIMTDSWGGTPLHDAAENGELECCQILV 292

  Fly   685 QHGTSV---DYNGKSSSQRHKSQQQLHQQHQQQQQQQQQQHLSSSCNSNSNSSKQTSRSNTIKSK 746
            .:|..:   |.:|.|::...:     :..|||             |.....:.:..|..:.:.|:
Zfish   293 VNGVDLGIRDQDGFSAADLAE-----YNGHQQ-------------CAKYLRTVENMSVEHRVLSR 339

  Fly   747 SSSTLSSDVEPFYLHPPALAGGSGGSGMGLGMGMGMGMGMSMGLGISRKNSDALYSQQSRSSSEK 811
            .:   |:|:|  |..|.:                          |:|..|
Zfish   340 DA---SADLE--YKQPDS--------------------------GLSSPN--------------- 358

  Fly   812 LYNGSSSLGGNPGGNSSSGGGGVGGGGGSGGALLPNDGLYVNPMRNGGMYNTPSPNGSISGESFF 876
                                           |.||      ||....|.::..||:.|:|
Zfish   359 -------------------------------ATLP------NPAPPAGHFDICSPSSSLS----- 381

  Fly   877 LHDPQDIIYNRVRDLFVDSDCSSSVKQHGKSHAHQLLQSKAGNAMTIQADVHSSSSGAGSGSDES 941

Zfish   382 ----------------------------------------------------------------- 381

  Fly   942 VSISSSFNSPKQQQQLRSQSFNRHGSSSNISASGNIKNNNYKAHKGKPSNQNGGGDHDYEDIYLV 1006

Zfish   382 ----------------------------------------------------------------- 381

  Fly  1007 REESRKQHQQQQQHQLQQQQQLQHQATQQQQQQQQQQQQLQHKYNVGRSRSRDSGSHSRSASASS 1071

Zfish   382 ----------------------------------------------------------------- 381

  Fly  1072 TRSTDIVLQYSNHHLNNKRNMNNNSNMNNSSSNIAQSSSSNNNNNSLLNRNKSHSIIGLHSSKYE 1136
                                       |..|:|.:|||:....:.|..:|        :.:...:
Zfish   382 ---------------------------NYDSANSSQSSTGEKRSGSPPSR--------VPTGGTD 411

  Fly  1137 SSLKDNYSAKNVNLKNQLLNGGIKSDTYESVCPPEDVAERTKQTHKNSMIRNNLADASSNNNTSG 1201
            |::.|                   ..||..:..|::..
Zfish   412 SAITD-------------------MQTYMDMLNPDEAC--------------------------- 430

  Fly  1202 SINNISNIGNMNGGNQSSRNLKRVSSAPPMQNLAVVNGPPPPP-----LPPPLRAPVQQQRNNLS 1261
                            .|.|.|..:..||.....    |||||     :|||
Zfish   431 ----------------GSHNAKEAAHLPPPPTFP----PPPPPSNPSHIPPP------------- 462

  Fly  1262 VDQPNSMTGNNGIYKKNVFGPNQGPTNANGTGGAAPPPVPAPNPVATE--------------AVD 1312
                                               ||..|||||...|              .||
Zfish   463 -----------------------------------PPAYPAPNPPEEEEVSAEYLKVKRNLRRVD 492

  Fly  1313 SDSGLEVVEEPSLRPSELVRGNHNRTMSTISANKKAKLLNAGSTNGSSIAASSDDSQSRYGGSVH 1377
            :|    ||::..|.|.|    ||.| :..:.:|:|::
Zfish   493 ND----VVKKEQLNPGE----NHER-LRRVDSNRKSR---------------------------- 520

  Fly  1378 AANGSAANGHFYGYSEGNKNQGSNGNGNGNGNGGGGNYHSHPNQPHYATGQPHQYTPSLYGGGSS 1442
                                                   |...||  :||
Zfish   521 ---------------------------------------SFSKQP--STG--------------- 529

  Fly  1443 AEDHY-----ELTQQQQQIYGETHLPSGQRTGGPNLVNKQLVLPFVPPSFPNKSQDGVTHLIKPS 1502
              |:|     :.|.||         ||  |...||                   ::|       |
Zfish   530 --DYYKTLGSDTTDQQ---------PS--RAMAPN-------------------EEG-------S 555

  Fly  1503 EYLKSISIDKRSCPSSARSTDTEDYMQIQIAQQQSHPHQHQHHPHPHPHPHHPHQLHGMGEQPPL 1567
            ..|:. :.|....|.:...| |||.                  |.|.|.|..|....     .|.
Zfish   556 ALLEE-AADTAPAPENGTGT-TEDL------------------PLPPPPPPPPASTF-----IPA 595

  Fly  1568 PPPPPPLPHGMLPPQPPMGPPMGVAGGQDATMSGKSHKPKKPHGS---APNSQDTATRKQHQPLS 1629
            ||||||||..:.||.||.......|..:.::.|.|.|. ...|.|   ||..:....||.::..:
Zfish   596 PPPPPPLPSELPPPPPPSTTTPAAAQRRMSSSSNKGHL-SSTHLSPSVAPAPETLRQRKSNKSFN 659

  Fly  1630 AISIQDLNSVQLRRTDTQK--VPKPYQMPARSLSMQCLTSSTETYLKSDLIAELKISKDIPGIK- 1691
            .:|....||..|......|  .|.|:.....::.....|........|.....|....|....|
Zfish   660 MMSPTGDNSELLAEIKAGKSLKPTPHSKGYTTVFSNSGTPGNNGESPSSPPEPLPKPNDTQSAKP 724

  Fly  1692 ----------------KMKVEQQMASRMDSEHYMEITKQFSGNNYVDQ-----------IPERDQ 1729
                            .....|.:::...|:   ::|...:||..|.|           :|..|:
Zfish   725 ESPPPACPPTPPNPTASRSSPQNLSTSQSSD---QLTAAVNGNTSVVQNKTSVVDVESLVPTHDE 786

  Fly  1730 AGNAIPDWKRQMMAKKAAERAKKDFEERMAQEAESRRLSQIPQWKRDLLARREETENKLKAAIYT 1794
            .|.|||:||||:|.:|...:.:::.|.:...|.|:.||:.:|.|:||::.::.|.||
Zfish   787 QGRAIPEWKRQVMVRKLQVKMQEEEENKRKAEEEAARLASLPAWRRDIMKKKLEEEN-------- 843

  Fly  1795 PKVEENNRVADTWRLKNRA 1813
            .|:|:..:..:..|::..:
Zfish   844 GKMEQKRKDEEQRRMEKES 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f	NP_001036284.1	Ank_2	<370..400	CDD:289560	10/27 (37%)
		ANK repeat	371..399	CDD:293786	10/26 (38%)
		ANK	558..684	CDD:238125	61/125 (49%)
		Ank_4	565..618	CDD:290365	28/52 (54%)
		ANK repeat	566..595	CDD:293786	15/28 (54%)
		ANK repeat	597..629	CDD:293786	11/31 (35%)
		Ank_2	602..693	CDD:289560	41/93 (44%)
		ANK repeat	631..660	CDD:293786	18/28 (64%)
		ANK repeat	663..691	CDD:293786	12/30 (40%)
espn	XP_009302528.1	Ank_4	4..56	CDD:290365	8/19 (42%)
		ANK	5..124	CDD:238125	26/155 (17%)
		ANK repeat	36..67	CDD:293786	12/46 (26%)
		Ank_4	38..90	CDD:290365	16/101 (16%)
		ANK repeat	69..101	CDD:293786	7/57 (12%)
		Ank_4	72..124	CDD:290365	13/95 (14%)
		ANK	100..226	CDD:238125	42/143 (29%)
		Ank_2	108..202	CDD:289560	28/111 (25%)
		ANK repeat	138..169	CDD:293786	3/30 (10%)
		ANK	166..292	CDD:238125	61/125 (49%)
		ANK repeat	171..203	CDD:293786	16/31 (52%)
		ANK repeat	205..269	CDD:293786	31/63 (49%)
		Ank_2	210..302	CDD:289560	40/91 (44%)
		ANK repeat	271..302	CDD:293786	12/30 (40%)
		CCDC66	744..>857	CDD:291889	33/123 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583529
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto40915
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24153
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5711
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.060