Protein Alignment f and Espn

DIOPT Version :10

• Sequence 1: NP_001036284.1
• Gene: f / 32718
• FlyBaseID: FBgn0262111
• Length: 1918
• Species: Drosophila melanogaster
• Sequence 2: XP_038966608.1
• Gene: Espn / 56227
• RGDID: 620652
• Length: 887
• Species: Rattus norvegicus
• Alignment Length: 1554
• Identity: 283/1554 - (18%)
• Similarity: 437/1554 - (28%)
• Gaps: 757/1554 - (48%)

  Fly   349 GGMGQVGQMYHPGSVSGSERPNGGALALHYAAARGCLDCVQLLVAASVDICYFSTINVKKGLLGR 413
            |.:..:..::..|.:..|.|....||.:|:||..|.|.|::.||.   ::...:....:.|....
  Rat    13 GDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVE---EVALPAVSRARNGATPA 74

  Fly   414 MTTSLTSYR------------RSKQKSKSNNDIHTIIA----TEVVTAAILSSSVHSSSTGSEIG 462
            ...:.|.|.            |.::|..|...:..:.|    .:||...:.....:|:.|    .
  Rat    75 HDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGANSAIT----T 135

  Fly   463 DGGQGNTSLIEEAAAQDQSSEEQDRQHQHAKDPLAQTEMNHHPHSHHQRKSAVEVVRQQMDDDGD 527
            |.|   ...|..|||:...             |..:..:.|:|
  Rat   136 DTG---ALPIHYAAAKGDL-------------PSMKLLVGHYP---------------------- 162

  Fly   528 QDSNDDDETMPMMSGVGRKEQNNRRSVVSANTQMDNDVTPVYLAAQEGHLEVLKFLVLEAGGSLY 592
                         .||              |.|.:|..||:|||.|||||||.|:||.|.....:
  Rat   163 -------------EGV--------------NAQTNNGATPLYLACQEGHLEVTKYLVQECSADPH 200

  Fly   593 VRARDGMAPIHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGHLSVVRWLLNHGAK 657
            :||:|||.|:|||:|||....|.|:|....|..:.:|.||||.:||||||||..|:.|||.|||:
  Rat   201 LRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAE 265

  Fly   658 LSLDKYGKSPINDAAENQQVECLNVLVQHGTSV--------------DYNGKSSSQRH-KSQQQL 707
            :|.|.:|.:|::|||||.::||..:|..:|..:              |:||.:...|: ::.|.|
  Rat   266 ISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYLRTVQTL 330

  Fly   708 HQQHQQQQQQQQQQHLSSSCNSNSNSSKQTSRSNTIKSKSSSTLSSDVEPFYLHPPALAGGSGGS 772
            ..:|:...:..... |.:....:..||..|:.|                   :.||....||..|
  Rat   331 SLEHRVLSRDPSMD-LEAKQPDSGMSSPNTTMS-------------------VQPPNFDLGSPTS 375

  Fly   773 GMGLGMGMGMGMGMSMGLGISRKNSDALYSQQSRSSSEKLYNGSSSLGGNPGGNSSSGGGGVG-- 835
                                      .|.:..|.|||.....|..|..|.||..||.....:.
  Rat   376 --------------------------TLSNYDSCSSSHSSSKGQRSTRGVPGARSSDLQSYMDML 414

  Fly   836 -----GGGGSGGAL----------LPNDGLYVNPMRNGGMYNTPSPNGSISGESFFLHDPQDIIY 885
                 ...|...:|          .|..|..:.|...|    .|:||..:.     ||  .|.||
  Rat   415 NPEPRSKQGKPSSLPPPPPPSFPPPPPPGTQLPPPPPG----YPAPNPPVG-----LH--LDNIY 468

  Fly   886 ----NRVRDLFVDSDCSSSVKQHGKSHAHQLLQSKAGNAMTIQADVHSSSSGAGSGSDESVSISS 946
                |::|.:.||     |:|:..|: .|
  Rat   469 MQTKNKLRHVEVD-----SLKKESKA-CH------------------------------------ 491

  Fly   947 SFNSPKQQQQLRSQSFNRHGSSSNISASGNIKNNNYKAHKGKPSNQNGGGDHDYEDIYLVREESR 1011
                ||.:                       .|:.:    .:||:.:|......:|..|:|::|
  Rat   492 ----PKVE-----------------------PNDQF----AQPSSGDGYSGLRRQDSGLLRQDS- 524

  Fly  1012 KQHQQQQQHQLQQQQQLQHQATQQQQQQQQQQQQLQHKYNVGRSRSRDSGSHSRSASASSTRSTD 1076
                         :..|:|....::|...::|:..        |:...:|.:.|....|
  Rat   525 -------------ELLLRHNTGLRRQDSDRKQRSF--------SKQPSTGDYYRQLGRS------ 562

  Fly  1077 IVLQYSNHHLNNKRNMNNNSNMNNSSSNIAQSSSSNNNNNSLLNRNKSHSIIGLHSSKYESSLKD 1141
                                                                             
  Rat   563 ----------------------------------------------------------------- 562

  Fly  1142 NYSAKNVNLKNQLLNGGIKSDTYESVCPPEDVAERTKQTHKNSMIRNNLADASSNNNTSGSINNI 1206
                                       |.|.:|.|....|...:..:..|.|
  Rat   563 ---------------------------PGEPLAARPGMAHSEEVRVHQPAPA------------- 587

  Fly  1207 SNIGNMNGGNQSSRNLKRVSSAPPMQNLA----VVNG-----------PPPPPLPPPLRAPVQQQ 1256
                ...|.|..|.:.....||||...|.    |.||           ||||| ||||
  Rat   588 ----GCTGSNPVSHSSLSGPSAPPQAALLPGNHVHNGCSADSKASRELPPPPP-PPPL------- 640

  Fly  1257 RNNLSVDQPNSMTGNNGIYKKNVFGPNQGPTNANGTGGAAPPPVPAPNPVATEAVDSDSGLEVVE 1321
                    |.::                          ::|||.|   |:..|...:..|
  Rat   641 --------PEAL--------------------------SSPPPAP---PLPIEGAGAACG----- 663

  Fly  1322 EPSLRPSELVRGNHNRTMSTISANKKAKLLNAGSTNGSSIAASSDDSQSRYGGSVHAANGSAANG 1386
                         ..|:.|:..:.|...:::....|...:|      :.:.|.|:
  Rat   664 -------------QRRSSSSTGSTKSFNMMSPTGDNSELLA------EIKAGKSL---------- 699

  Fly  1387 HFYGYSEGNKNQGSNGNGNGNGNGGGGNYHSHPNQPHYATGQPHQYTPSLYGGGSSAEDHYELTQ 1451
                                              :|   |.|....| :::.|
  Rat   700 ----------------------------------KP---TPQSKGLT-TVFSG------------ 714

  Fly  1452 QQQQIYGETHLPSGQRTGGPNLVNKQLVLPFVPPSFPNKSQDGVTHLIKPSEYLKSISIDKRSCP 1516
                        |||                 |.|.|...|..|:    |.             |
  Rat   715 ------------SGQ-----------------PASQPESPQPAVS----PG-------------P 733

  Fly  1517 SSARSTDTEDYMQIQIAQQQSHPHQHQHHPHPHPHPHHPHQLHGMGEQPPLPPP--PPPLPHGML 1579
            |.|||                                            |.||.  |.||.:|.:
  Rat   734 SRARS--------------------------------------------PTPPASGPQPLLNGSI 754

  Fly  1580 PPQPPMGPPMGVAGGQDATMSGKSHKPKKPHGSAPNSQDTATRKQHQPLSAISIQDLNSVQLRRT 1644
            .|.||            ||::
  Rat   755 VPAPP------------ATLA-------------------------------------------- 763

  Fly  1645 DTQKVPKPYQMPARSLSMQCLTSSTETYLKSDLIAELKISKDIPGIKKMKVEQQMASRMDSEHYM 1709
                                                       ||:           .:|.|..
  Rat   764 -------------------------------------------PGV-----------HLDVEAL- 773

  Fly  1710 EITKQFSGNNYVDQIPERDQAGNAIPDWKRQMMAKKAAERAKKDFEERMAQEAESRRLSQIPQWK 1774
                          ||..|:.|..||:||||:|.:|..::.:::.|:|..:|.|..||:.:|.|:
  Rat   774 --------------IPTLDEQGRPIPEWKRQVMVRKLQQKMQEEEEQRRKEEEEEARLASLPAWR 824

  Fly  1775 RDLLARREETENKLKAAIYTPKVEENNRVADTWRLKNRAMSIDNININLAGMEQHYQQI 1833
            ||:|.::.|.|.:.|.     |.||..::.:..|.|.::..:..:..:.|.:....:|:
  Rat   825 RDILRKKLEEEREQKR-----KEEERQKLEEIQRAKEQSEKLRTLGYDEAKLAPWQRQV 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
f	NP_001036284.1	ANK repeat	371..399	CDD:293786	10/27 (37%)
		ANKYR	<558..695	CDD:440430	70/150 (47%)
		ANK repeat	566..595	CDD:293786	16/28 (57%)
		ANK repeat	597..629	CDD:293786	14/31 (45%)
		ANK repeat	631..660	CDD:293786	19/28 (68%)
		ANK repeat	663..691	CDD:293786	11/41 (27%)
Espn	XP_038966608.1	ANK repeat	39..67	CDD:293786	8/30 (27%)
		ANKYR	52..324	CDD:440430	96/343 (28%)
		ANK repeat	69..101	CDD:293786	4/31 (13%)
		ANK repeat	103..135	CDD:293786	6/35 (17%)
		ANK repeat	137..169	CDD:293786	11/96 (11%)
		ANK repeat	171..202	CDD:293786	17/30 (57%)
		ANK repeat	205..237	CDD:293786	14/31 (45%)
		ANK repeat	239..269	CDD:293786	20/29 (69%)
		ANK repeat	271..302	CDD:293786	11/30 (37%)
		WH2	682..707	CDD:460490	7/77 (9%)